Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1592c

Experiment: 7H9 with Norfloxacin 0.125 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1590 and Rv1591 overlap by 4 nucleotidesRv1591 and Rv1592c are separated by 164 nucleotidesRv1592c and Rv1593c are separated by 256 nucleotides Rv1590: Rv1590 - Conserved hypothetical protein, at 1,791,334 to 1,791,573 Rv1590 Rv1591: Rv1591 - Probable transmembrane protein, at 1,791,570 to 1,792,235 Rv1591 Rv1592c: Rv1592c - Conserved hypothetical protein, at 1,792,400 to 1,793,740 Rv1592c Rv1593c: Rv1593c - Conserved protein, at 1,793,997 to 1,794,707 Rv1593c Position (kb) 1792 1793 1794Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 1791.414 kb on + strand, within Rv1590at 1791.766 kb on - strand, within Rv1591at 1791.766 kb on - strand, within Rv1591at 1791.766 kb on - strand, within Rv1591at 1791.806 kb on + strand, within Rv1591at 1791.807 kb on - strand, within Rv1591at 1792.026 kb on + strand, within Rv1591at 1792.027 kb on - strand, within Rv1591at 1792.027 kb on - strand, within Rv1591at 1792.118 kb on - strand, within Rv1591at 1792.197 kb on - strandat 1792.197 kb on - strandat 1792.234 kb on - strandat 1792.626 kb on + strand, within Rv1592cat 1792.627 kb on - strand, within Rv1592cat 1792.651 kb on + strand, within Rv1592cat 1792.651 kb on + strand, within Rv1592cat 1792.651 kb on + strand, within Rv1592cat 1792.651 kb on + strand, within Rv1592cat 1792.652 kb on - strand, within Rv1592cat 1792.652 kb on - strand, within Rv1592cat 1792.653 kb on + strand, within Rv1592cat 1792.653 kb on + strand, within Rv1592cat 1792.653 kb on + strand, within Rv1592cat 1792.653 kb on + strand, within Rv1592cat 1792.654 kb on - strand, within Rv1592cat 1792.654 kb on - strand, within Rv1592cat 1792.654 kb on - strand, within Rv1592cat 1792.654 kb on - strand, within Rv1592cat 1792.654 kb on - strand, within Rv1592cat 1792.695 kb on + strand, within Rv1592cat 1792.695 kb on + strand, within Rv1592cat 1792.695 kb on + strand, within Rv1592cat 1792.695 kb on + strand, within Rv1592cat 1792.696 kb on - strand, within Rv1592cat 1792.721 kb on + strand, within Rv1592cat 1792.744 kb on + strand, within Rv1592cat 1792.859 kb on + strand, within Rv1592cat 1792.859 kb on + strand, within Rv1592cat 1792.944 kb on + strand, within Rv1592cat 1792.945 kb on - strand, within Rv1592cat 1793.066 kb on + strand, within Rv1592cat 1793.067 kb on - strand, within Rv1592cat 1793.067 kb on - strand, within Rv1592cat 1793.067 kb on - strand, within Rv1592cat 1793.067 kb on - strand, within Rv1592cat 1793.080 kb on - strand, within Rv1592cat 1793.226 kb on + strand, within Rv1592cat 1793.227 kb on - strand, within Rv1592cat 1793.364 kb on + strand, within Rv1592cat 1793.364 kb on + strand, within Rv1592cat 1793.409 kb on + strand, within Rv1592cat 1793.410 kb on - strand, within Rv1592cat 1793.490 kb on + strand, within Rv1592cat 1793.491 kb on - strand, within Rv1592cat 1793.551 kb on + strand, within Rv1592cat 1793.625 kb on + strandat 1793.735 kb on + strandat 1793.741 kb on + strandat 1793.741 kb on + strandat 1793.903 kb on + strandat 1793.948 kb on + strandat 1794.045 kb on + strandat 1794.046 kb on - strandat 1794.067 kb on + strandat 1794.179 kb on - strand, within Rv1593cat 1794.403 kb on + strand, within Rv1593cat 1794.404 kb on - strand, within Rv1593cat 1794.404 kb on - strand, within Rv1593cat 1794.404 kb on - strand, within Rv1593cat 1794.469 kb on - strand, within Rv1593c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Norfloxacin 0.125 mM
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1,791,414 + Rv1590 0.33 -0.6
1,791,766 - Rv1591 0.29 -0.5
1,791,766 - Rv1591 0.29 -1.3
1,791,766 - Rv1591 0.29 +0.6
1,791,806 + Rv1591 0.35 +0.3
1,791,807 - Rv1591 0.36 -0.1
1,792,026 + Rv1591 0.68 -1.0
1,792,027 - Rv1591 0.69 -1.3
1,792,027 - Rv1591 0.69 -0.0
1,792,118 - Rv1591 0.82 +0.7
1,792,197 - -0.5
1,792,197 - -0.2
1,792,234 - -0.3
1,792,626 + Rv1592c 0.17 -0.1
1,792,627 - Rv1592c 0.17 -0.7
1,792,651 + Rv1592c 0.19 -0.4
1,792,651 + Rv1592c 0.19 -1.1
1,792,651 + Rv1592c 0.19 -0.8
1,792,651 + Rv1592c 0.19 -1.7
1,792,652 - Rv1592c 0.19 -0.5
1,792,652 - Rv1592c 0.19 +1.9
1,792,653 + Rv1592c 0.19 -0.6
1,792,653 + Rv1592c 0.19 -0.3
1,792,653 + Rv1592c 0.19 -0.3
1,792,653 + Rv1592c 0.19 -0.8
1,792,654 - Rv1592c 0.19 -0.5
1,792,654 - Rv1592c 0.19 -0.2
1,792,654 - Rv1592c 0.19 +0.1
1,792,654 - Rv1592c 0.19 -0.3
1,792,654 - Rv1592c 0.19 -0.1
1,792,695 + Rv1592c 0.22 -1.4
1,792,695 + Rv1592c 0.22 -0.5
1,792,695 + Rv1592c 0.22 -0.4
1,792,695 + Rv1592c 0.22 -0.7
1,792,696 - Rv1592c 0.22 +0.3
1,792,721 + Rv1592c 0.24 -1.0
1,792,744 + Rv1592c 0.26 -0.1
1,792,859 + Rv1592c 0.34 -2.0
1,792,859 + Rv1592c 0.34 -0.5
1,792,944 + Rv1592c 0.41 -0.3
1,792,945 - Rv1592c 0.41 +0.1
1,793,066 + Rv1592c 0.50 -0.6
1,793,067 - Rv1592c 0.50 -0.7
1,793,067 - Rv1592c 0.50 -0.1
1,793,067 - Rv1592c 0.50 -1.5
1,793,067 - Rv1592c 0.50 -0.2
1,793,080 - Rv1592c 0.51 -0.9
1,793,226 + Rv1592c 0.62 -0.2
1,793,227 - Rv1592c 0.62 -1.1
1,793,364 + Rv1592c 0.72 -0.2
1,793,364 + Rv1592c 0.72 -2.8
1,793,409 + Rv1592c 0.75 -0.4
1,793,410 - Rv1592c 0.75 -0.3
1,793,490 + Rv1592c 0.81 +1.9
1,793,491 - Rv1592c 0.81 -1.7
1,793,551 + Rv1592c 0.86 -1.2
1,793,625 + -0.5
1,793,735 + +0.1
1,793,741 + -0.3
1,793,741 + -0.8
1,793,903 + +0.3
1,793,948 + -0.9
1,794,045 + -2.0
1,794,046 - -0.1
1,794,067 + +2.5
1,794,179 - Rv1593c 0.26 -0.3
1,794,403 + Rv1593c 0.57 +0.3
1,794,404 - Rv1593c 0.57 -0.7
1,794,404 - Rv1593c 0.57 -1.1
1,794,404 - Rv1593c 0.57 -0.4
1,794,469 - Rv1593c 0.66 -0.3

Or see this region's nucleotide sequence