Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1638

Experiment: 7H9 with Formaldehyde 0.23 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1636 and Rv1637c are separated by 6 nucleotidesRv1637c and Rv1638 are separated by 48 nucleotidesRv1638 and Rv1638A are separated by 56 nucleotidesRv1638A and Rv1639c are separated by 15 nucleotides Rv1636: Rv1636 - Iron-regulated universal stress protein family protein TB15.3, at 1,842,451 to 1,842,891 Rv1636 Rv1637c: Rv1637c - Conserved protein, at 1,842,898 to 1,843,692 Rv1637c Rv1638: Rv1638 - Probable excinuclease ABC (subunit A-DNA-binding ATPase) UvrA, at 1,843,741 to 1,846,659 Rv1638 Rv1638A: Rv1638A - Conserved hypothetical protein, at 1,846,716 to 1,846,973 Rv1638A Rv1639c: Rv1639c - Conserved hypothetical membrane protein, at 1,846,989 to 1,848,458 Rv1639c Position (kb) 1843 1844 1845 1846 1847Strain fitness (log2 ratio) -4 -3 -2 -1 0 1 2at 1842.890 kb on - strandat 1842.899 kb on + strandat 1842.974 kb on + strandat 1842.975 kb on - strandat 1842.975 kb on - strandat 1842.995 kb on + strand, within Rv1637cat 1842.996 kb on - strand, within Rv1637cat 1843.371 kb on - strand, within Rv1637cat 1843.553 kb on + strand, within Rv1637cat 1843.554 kb on - strand, within Rv1637cat 1843.554 kb on - strand, within Rv1637cat 1843.576 kb on - strand, within Rv1637cat 1843.632 kb on + strandat 1843.645 kb on + strandat 1843.687 kb on + strandat 1843.687 kb on + strandat 1843.687 kb on + strandat 1843.688 kb on - strandat 1843.688 kb on - strandat 1843.688 kb on - strandat 1843.900 kb on + strandat 1843.922 kb on - strandat 1844.056 kb on + strand, within Rv1638at 1844.077 kb on + strand, within Rv1638at 1844.245 kb on - strand, within Rv1638at 1844.708 kb on - strand, within Rv1638at 1845.310 kb on + strand, within Rv1638at 1845.524 kb on + strand, within Rv1638at 1845.890 kb on - strand, within Rv1638at 1846.058 kb on - strand, within Rv1638at 1846.117 kb on + strand, within Rv1638at 1846.118 kb on - strand, within Rv1638at 1846.118 kb on - strand, within Rv1638at 1846.204 kb on + strand, within Rv1638at 1846.205 kb on - strand, within Rv1638at 1846.208 kb on + strand, within Rv1638at 1846.209 kb on - strand, within Rv1638at 1846.209 kb on - strand, within Rv1638at 1846.209 kb on - strand, within Rv1638at 1846.209 kb on - strand, within Rv1638at 1846.209 kb on - strand, within Rv1638at 1846.237 kb on + strand, within Rv1638at 1846.340 kb on - strand, within Rv1638at 1846.382 kb on + strandat 1846.382 kb on + strandat 1846.382 kb on + strandat 1846.428 kb on + strandat 1846.449 kb on + strandat 1846.990 kb on + strandat 1847.324 kb on - strand, within Rv1639cat 1847.324 kb on - strand, within Rv1639cat 1847.462 kb on + strand, within Rv1639cat 1847.576 kb on - strand, within Rv1639c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Formaldehyde 0.23 mM
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1,842,890 - -0.0
1,842,899 + -0.3
1,842,974 + -1.7
1,842,975 - -0.5
1,842,975 - -1.3
1,842,995 + Rv1637c 0.12 -1.1
1,842,996 - Rv1637c 0.12 +1.2
1,843,371 - Rv1637c 0.59 -0.3
1,843,553 + Rv1637c 0.82 -1.0
1,843,554 - Rv1637c 0.83 -0.4
1,843,554 - Rv1637c 0.83 -0.1
1,843,576 - Rv1637c 0.85 +1.8
1,843,632 + +0.6
1,843,645 + +1.8
1,843,687 + +0.3
1,843,687 + -0.3
1,843,687 + -1.0
1,843,688 - +0.0
1,843,688 - -0.2
1,843,688 - -0.2
1,843,900 + -2.9
1,843,922 - -2.1
1,844,056 + Rv1638 0.11 -1.7
1,844,077 + Rv1638 0.12 +0.1
1,844,245 - Rv1638 0.17 -1.5
1,844,708 - Rv1638 0.33 -1.2
1,845,310 + Rv1638 0.54 -2.5
1,845,524 + Rv1638 0.61 -1.4
1,845,890 - Rv1638 0.74 -2.4
1,846,058 - Rv1638 0.79 -1.9
1,846,117 + Rv1638 0.81 -3.8
1,846,118 - Rv1638 0.81 -2.5
1,846,118 - Rv1638 0.81 +1.8
1,846,204 + Rv1638 0.84 -3.6
1,846,205 - Rv1638 0.84 -2.6
1,846,208 + Rv1638 0.85 -2.0
1,846,209 - Rv1638 0.85 -0.0
1,846,209 - Rv1638 0.85 -2.4
1,846,209 - Rv1638 0.85 -2.7
1,846,209 - Rv1638 0.85 -2.4
1,846,209 - Rv1638 0.85 -2.8
1,846,237 + Rv1638 0.86 -0.7
1,846,340 - Rv1638 0.89 -1.0
1,846,382 + -2.3
1,846,382 + -3.3
1,846,382 + -3.8
1,846,428 + +0.6
1,846,449 + -1.5
1,846,990 + -1.3
1,847,324 - Rv1639c 0.23 -2.4
1,847,324 - Rv1639c 0.23 +0.1
1,847,462 + Rv1639c 0.32 -0.2
1,847,576 - Rv1639c 0.40 -0.1

Or see this region's nucleotide sequence