Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1377c

Experiment: 7H9 with Formaldehyde 0.23 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1376 and Rv1377c overlap by 63 nucleotidesRv1377c and Rv1378c are separated by 10 nucleotides Rv1376: Rv1376 - Conserved hypothetical protein, at 1,549,148 to 1,550,641 Rv1376 Rv1377c: Rv1377c - Putative transferase, at 1,550,579 to 1,551,217 Rv1377c Rv1378c: Rv1378c - Conserved hypothetical protein, at 1,551,228 to 1,552,655 Rv1378c Position (kb) 1550 1551 1552Strain fitness (log2 ratio) -1 0 1 2 3at 1549.961 kb on + strand, within Rv1376at 1549.962 kb on - strand, within Rv1376at 1550.114 kb on + strand, within Rv1376at 1550.114 kb on + strand, within Rv1376at 1550.115 kb on - strand, within Rv1376at 1550.510 kb on + strandat 1550.510 kb on + strandat 1550.510 kb on + strandat 1550.510 kb on + strandat 1550.511 kb on - strandat 1550.580 kb on + strandat 1550.827 kb on - strand, within Rv1377cat 1551.033 kb on + strand, within Rv1377cat 1551.034 kb on - strand, within Rv1377cat 1551.034 kb on - strand, within Rv1377cat 1551.034 kb on - strand, within Rv1377cat 1551.207 kb on - strandat 1551.207 kb on - strandat 1551.207 kb on - strandat 1551.229 kb on + strandat 1551.230 kb on - strandat 1551.240 kb on + strandat 1551.288 kb on + strandat 1551.289 kb on - strandat 1551.331 kb on + strandat 1551.331 kb on + strandat 1551.332 kb on - strandat 1551.421 kb on + strand, within Rv1378cat 1551.421 kb on + strand, within Rv1378cat 1551.421 kb on + strand, within Rv1378cat 1551.421 kb on + strand, within Rv1378cat 1551.422 kb on - strand, within Rv1378cat 1551.422 kb on - strand, within Rv1378cat 1551.422 kb on - strand, within Rv1378cat 1551.422 kb on - strand, within Rv1378cat 1551.425 kb on + strand, within Rv1378cat 1551.523 kb on + strand, within Rv1378cat 1551.523 kb on + strand, within Rv1378cat 1551.634 kb on + strand, within Rv1378cat 1551.756 kb on + strand, within Rv1378cat 1551.756 kb on + strand, within Rv1378cat 1551.852 kb on + strand, within Rv1378cat 1551.853 kb on - strand, within Rv1378c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Formaldehyde 0.23 mM
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1,549,961 + Rv1376 0.54 +0.6
1,549,962 - Rv1376 0.54 -0.3
1,550,114 + Rv1376 0.65 -0.6
1,550,114 + Rv1376 0.65 -1.7
1,550,115 - Rv1376 0.65 -0.2
1,550,510 + -0.3
1,550,510 + +0.0
1,550,510 + +3.4
1,550,510 + -1.7
1,550,511 - -0.4
1,550,580 + -1.6
1,550,827 - Rv1377c 0.39 +0.1
1,551,033 + Rv1377c 0.71 -0.9
1,551,034 - Rv1377c 0.71 -0.7
1,551,034 - Rv1377c 0.71 -0.4
1,551,034 - Rv1377c 0.71 -1.2
1,551,207 - +0.7
1,551,207 - +0.2
1,551,207 - -0.6
1,551,229 + -0.0
1,551,230 - +2.8
1,551,240 + -0.3
1,551,288 + -0.1
1,551,289 - -0.6
1,551,331 + -0.3
1,551,331 + -0.5
1,551,332 - +2.1
1,551,421 + Rv1378c 0.14 -0.0
1,551,421 + Rv1378c 0.14 +0.3
1,551,421 + Rv1378c 0.14 -0.3
1,551,421 + Rv1378c 0.14 +0.9
1,551,422 - Rv1378c 0.14 +1.1
1,551,422 - Rv1378c 0.14 +0.0
1,551,422 - Rv1378c 0.14 -0.2
1,551,422 - Rv1378c 0.14 +1.2
1,551,425 + Rv1378c 0.14 -0.2
1,551,523 + Rv1378c 0.21 -0.8
1,551,523 + Rv1378c 0.21 +0.4
1,551,634 + Rv1378c 0.28 +1.6
1,551,756 + Rv1378c 0.37 -0.1
1,551,756 + Rv1378c 0.37 +0.2
1,551,852 + Rv1378c 0.44 -0.4
1,551,853 - Rv1378c 0.44 -0.4

Or see this region's nucleotide sequence