Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0092

Experiment: 7H9 with Formaldehyde 0.23 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0091 and Rv0092 are separated by 131 nucleotidesRv0092 and Rv0093c overlap by 54 nucleotidesRv0093c and Rv0094c are separated by 46 nucleotides Rv0091: Rv0091 - Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase) + S-adenosylhomocysteine nucleosidase (S-adenosyl-L-homocysteine homocysteinylribohydrolase), at 99,684 to 100,451 Rv0091 Rv0092: Rv0092 - Cation transporter P-type ATPase a CtpA, at 100,583 to 102,868 Rv0092 Rv0093c: Rv0093c - Probable conserved membrane protein, at 102,815 to 103,663 Rv0093c Rv0094c: Rv0094c - Conserved hypothetical protein, at 103,710 to 104,663 Rv0094c Position (kb) 100 101 102 103Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 99.940 kb on + strand, within Rv0091at 99.941 kb on - strand, within Rv0091at 99.941 kb on - strand, within Rv0091at 100.021 kb on - strand, within Rv0091at 100.176 kb on + strand, within Rv0091at 100.179 kb on + strand, within Rv0091at 100.179 kb on + strand, within Rv0091at 100.207 kb on - strand, within Rv0091at 100.207 kb on - strand, within Rv0091at 100.505 kb on + strandat 100.517 kb on + strandat 100.518 kb on - strandat 100.629 kb on + strandat 100.805 kb on + strandat 100.983 kb on + strand, within Rv0092at 100.984 kb on - strand, within Rv0092at 101.124 kb on - strand, within Rv0092at 101.124 kb on - strand, within Rv0092at 101.195 kb on - strand, within Rv0092at 101.195 kb on - strand, within Rv0092at 101.319 kb on + strand, within Rv0092at 101.320 kb on - strand, within Rv0092at 101.409 kb on + strand, within Rv0092at 101.409 kb on + strand, within Rv0092at 101.410 kb on - strand, within Rv0092at 101.643 kb on + strand, within Rv0092at 101.644 kb on - strand, within Rv0092at 101.851 kb on - strand, within Rv0092at 102.531 kb on + strand, within Rv0092at 102.613 kb on - strand, within Rv0092at 103.405 kb on + strand, within Rv0093cat 103.534 kb on + strand, within Rv0093c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Formaldehyde 0.23 mM
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99,940 + Rv0091 0.33 -0.0
99,941 - Rv0091 0.33 -0.2
99,941 - Rv0091 0.33 +0.4
100,021 - Rv0091 0.44 -1.2
100,176 + Rv0091 0.64 +0.0
100,179 + Rv0091 0.64 +0.8
100,179 + Rv0091 0.64 -2.8
100,207 - Rv0091 0.68 +0.9
100,207 - Rv0091 0.68 +1.3
100,505 + -0.6
100,517 + +0.1
100,518 - +1.8
100,629 + +0.1
100,805 + -0.7
100,983 + Rv0092 0.17 -2.2
100,984 - Rv0092 0.18 +0.2
101,124 - Rv0092 0.24 -1.7
101,124 - Rv0092 0.24 -1.0
101,195 - Rv0092 0.27 -0.6
101,195 - Rv0092 0.27 -0.7
101,319 + Rv0092 0.32 -0.4
101,320 - Rv0092 0.32 -2.0
101,409 + Rv0092 0.36 -0.2
101,409 + Rv0092 0.36 +1.1
101,410 - Rv0092 0.36 -1.2
101,643 + Rv0092 0.46 -0.8
101,644 - Rv0092 0.46 -3.7
101,851 - Rv0092 0.55 -0.7
102,531 + Rv0092 0.85 -1.7
102,613 - Rv0092 0.89 -2.7
103,405 + Rv0093c 0.69 +0.3
103,534 + Rv0093c 0.85 +0.2

Or see this region's nucleotide sequence