Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0806c

Experiment: 7H9 with methylglyoxal 1.2 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0805 and Rv0806c overlap by 56 nucleotidesRv0806c and Rv0807 are separated by 304 nucleotidesRv0807 and Rv0808 are separated by 86 nucleotides Rv0805: Rv0805 - Class III cyclic nucleotide phosphodiesterase (cNMP PDE), at 898,831 to 899,787 Rv0805 Rv0806c: Rv0806c - Possible UDP-glucose-4-epimerase CpsY (galactowaldenase) (UDP-galactose-4-epimerase) (uridine diphosphate galactose-4-epimerase) (uridine diphospho-galactose-4-epimerase), at 899,732 to 901,330 Rv0806c Rv0807: Rv0807 - Conserved hypothetical protein, at 901,635 to 902,024 Rv0807 Rv0808: Rv0808 - Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase), at 902,111 to 903,694 Rv0808 Position (kb) 899 900 901 902Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 898.780 kb on - strandat 898.799 kb on + strandat 898.837 kb on - strandat 898.837 kb on - strandat 898.843 kb on - strandat 898.870 kb on + strandat 898.880 kb on + strandat 898.880 kb on + strandat 898.880 kb on + strandat 898.880 kb on + strandat 898.881 kb on - strandat 898.884 kb on + strandat 898.884 kb on + strandat 898.884 kb on + strandat 898.885 kb on - strandat 899.028 kb on + strand, within Rv0805at 899.119 kb on - strand, within Rv0805at 899.891 kb on - strandat 899.891 kb on - strandat 899.938 kb on + strand, within Rv0806cat 899.962 kb on - strand, within Rv0806cat 899.980 kb on - strand, within Rv0806cat 899.990 kb on - strand, within Rv0806cat 900.030 kb on + strand, within Rv0806cat 900.033 kb on + strand, within Rv0806cat 900.039 kb on + strand, within Rv0806cat 900.040 kb on - strand, within Rv0806cat 900.040 kb on - strand, within Rv0806cat 900.181 kb on + strand, within Rv0806cat 900.328 kb on + strand, within Rv0806cat 900.434 kb on - strand, within Rv0806cat 900.434 kb on - strand, within Rv0806cat 900.435 kb on + strand, within Rv0806cat 900.436 kb on - strand, within Rv0806cat 900.436 kb on - strand, within Rv0806cat 900.436 kb on - strand, within Rv0806cat 900.552 kb on - strand, within Rv0806cat 900.648 kb on + strand, within Rv0806cat 900.723 kb on - strand, within Rv0806cat 900.784 kb on - strand, within Rv0806cat 901.037 kb on - strand, within Rv0806cat 901.047 kb on + strand, within Rv0806cat 901.100 kb on + strand, within Rv0806cat 901.101 kb on - strand, within Rv0806cat 901.162 kb on + strand, within Rv0806cat 901.367 kb on - strandat 901.457 kb on - strandat 901.487 kb on + strandat 901.558 kb on + strandat 901.559 kb on - strandat 901.559 kb on - strandat 901.559 kb on - strandat 901.559 kb on - strandat 901.559 kb on - strandat 901.559 kb on - strandat 901.634 kb on + strandat 901.634 kb on + strandat 901.635 kb on - strandat 901.761 kb on - strand, within Rv0807at 902.085 kb on - strandat 902.118 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with methylglyoxal 1.2 mM
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898,780 - -2.2
898,799 + +0.5
898,837 - -2.1
898,837 - +0.8
898,843 - -2.5
898,870 + -1.2
898,880 + -0.5
898,880 + -1.1
898,880 + -0.6
898,880 + -0.4
898,881 - -2.3
898,884 + -3.3
898,884 + +0.5
898,884 + +1.8
898,885 - -0.3
899,028 + Rv0805 0.21 -2.1
899,119 - Rv0805 0.30 -0.8
899,891 - -0.3
899,891 - +1.8
899,938 + Rv0806c 0.13 +1.2
899,962 - Rv0806c 0.14 +1.8
899,980 - Rv0806c 0.16 -0.9
899,990 - Rv0806c 0.16 -1.4
900,030 + Rv0806c 0.19 -1.5
900,033 + Rv0806c 0.19 -0.8
900,039 + Rv0806c 0.19 -1.1
900,040 - Rv0806c 0.19 -0.4
900,040 - Rv0806c 0.19 +0.8
900,181 + Rv0806c 0.28 -0.8
900,328 + Rv0806c 0.37 -1.2
900,434 - Rv0806c 0.44 +0.2
900,434 - Rv0806c 0.44 -1.4
900,435 + Rv0806c 0.44 -0.8
900,436 - Rv0806c 0.44 -0.9
900,436 - Rv0806c 0.44 -0.9
900,436 - Rv0806c 0.44 -1.2
900,552 - Rv0806c 0.51 -0.4
900,648 + Rv0806c 0.57 +0.5
900,723 - Rv0806c 0.62 -0.9
900,784 - Rv0806c 0.66 +0.1
901,037 - Rv0806c 0.82 -1.1
901,047 + Rv0806c 0.82 -1.5
901,100 + Rv0806c 0.86 +1.4
901,101 - Rv0806c 0.86 -1.1
901,162 + Rv0806c 0.89 -0.5
901,367 - -1.3
901,457 - -1.4
901,487 + -1.7
901,558 + -0.3
901,559 - -0.4
901,559 - -0.0
901,559 - -0.1
901,559 - -2.0
901,559 - -0.3
901,559 - +0.3
901,634 + +2.0
901,634 + -0.6
901,635 - -0.8
901,761 - Rv0807 0.32 +1.6
902,085 - -1.3
902,118 + -1.0

Or see this region's nucleotide sequence