Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3410c

Experiment: 7H9 with Ciprofloxacin Hydrochloride 0.001 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3409c and Rv3410c are separated by 55 nucleotidesRv3410c and Rv3411c are separated by 19 nucleotides Rv3409c: Rv3409c - Cholesterol oxidase ChoD (cholesterol-O2 oxidoreductase), at 3,826,991 to 3,828,727 Rv3409c Rv3410c: Rv3410c - Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD), at 3,828,783 to 3,829,910 Rv3410c Rv3411c: Rv3411c - Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD), at 3,829,930 to 3,831,519 Rv3411c Position (kb) 3828 3829 3830Strain fitness (log2 ratio) -2 -1 0 1at 3827.882 kb on - strand, within Rv3409cat 3828.369 kb on + strand, within Rv3409cat 3828.370 kb on - strand, within Rv3409cat 3828.447 kb on + strand, within Rv3409cat 3828.448 kb on - strand, within Rv3409cat 3828.448 kb on - strand, within Rv3409cat 3828.526 kb on + strand, within Rv3409cat 3828.526 kb on + strand, within Rv3409cat 3828.527 kb on - strand, within Rv3409cat 3828.714 kb on + strandat 3828.736 kb on + strandat 3828.736 kb on + strandat 3828.737 kb on - strandat 3828.737 kb on - strandat 3828.748 kb on + strandat 3828.749 kb on - strandat 3828.749 kb on - strandat 3828.749 kb on - strandat 3828.749 kb on - strandat 3828.763 kb on - strandat 3829.941 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ciprofloxacin Hydrochloride 0.001 mM
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3,827,882 - Rv3409c 0.51 -0.1
3,828,369 + Rv3409c 0.79 -0.3
3,828,370 - Rv3409c 0.79 -1.3
3,828,447 + Rv3409c 0.84 -0.4
3,828,448 - Rv3409c 0.84 +0.7
3,828,448 - Rv3409c 0.84 -0.2
3,828,526 + Rv3409c 0.88 -2.1
3,828,526 + Rv3409c 0.88 -1.0
3,828,527 - Rv3409c 0.88 -0.9
3,828,714 + -0.5
3,828,736 + -0.5
3,828,736 + +0.1
3,828,737 - -0.8
3,828,737 - -1.6
3,828,748 + -0.9
3,828,749 - -0.5
3,828,749 - -0.2
3,828,749 - +0.2
3,828,749 - +0.1
3,828,763 - +0.2
3,829,941 - +0.1

Or see this region's nucleotide sequence