Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2688c

Experiment: 7H9 with Ciprofloxacin Hydrochloride 0.001 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2686c and Rv2687c overlap by 4 nucleotidesRv2687c and Rv2688c overlap by 4 nucleotidesRv2688c and Rv2689c are separated by 194 nucleotides Rv2686c: Rv2686c - Antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter, at 3,003,280 to 3,004,038 Rv2686c Rv2687c: Rv2687c - Antibiotic-transport integral membrane leucine and valine rich protein ABC transporter, at 3,004,035 to 3,004,748 Rv2687c Rv2688c: Rv2688c - Antibiotic-transport ATP-binding protein ABC transporter, at 3,004,745 to 3,005,650 Rv2688c Rv2689c: Rv2689c - Conserved alanine and valine and glycine rich protein, at 3,005,845 to 3,007,062 Rv2689c Position (kb) 3004 3005 3006Strain fitness (log2 ratio) -3 -2 -1 0 1at 3004.064 kb on - strandat 3004.213 kb on + strand, within Rv2687cat 3004.214 kb on - strand, within Rv2687cat 3004.604 kb on - strand, within Rv2687cat 3004.662 kb on - strand, within Rv2687cat 3004.707 kb on + strandat 3004.805 kb on - strandat 3005.211 kb on + strand, within Rv2688cat 3005.212 kb on - strand, within Rv2688cat 3005.222 kb on + strand, within Rv2688cat 3005.223 kb on - strand, within Rv2688cat 3005.292 kb on + strand, within Rv2688cat 3005.293 kb on - strand, within Rv2688cat 3005.322 kb on + strand, within Rv2688cat 3005.380 kb on - strand, within Rv2688cat 3005.498 kb on + strand, within Rv2688cat 3005.499 kb on - strand, within Rv2688cat 3005.499 kb on - strand, within Rv2688cat 3005.730 kb on + strandat 3005.772 kb on + strandat 3005.772 kb on + strandat 3005.773 kb on - strandat 3005.775 kb on + strandat 3005.775 kb on + strandat 3005.789 kb on + strandat 3005.790 kb on - strandat 3005.847 kb on - strandat 3005.847 kb on - strandat 3005.882 kb on + strandat 3005.882 kb on + strandat 3005.883 kb on - strandat 3005.883 kb on - strandat 3005.988 kb on + strand, within Rv2689cat 3005.988 kb on + strand, within Rv2689cat 3005.988 kb on + strand, within Rv2689cat 3005.989 kb on - strand, within Rv2689cat 3005.989 kb on - strand, within Rv2689cat 3005.989 kb on - strand, within Rv2689cat 3005.989 kb on - strand, within Rv2689cat 3005.992 kb on + strand, within Rv2689cat 3005.992 kb on + strand, within Rv2689cat 3005.993 kb on - strand, within Rv2689cat 3005.993 kb on - strand, within Rv2689cat 3005.993 kb on - strand, within Rv2689cat 3005.993 kb on - strand, within Rv2689cat 3005.993 kb on - strand, within Rv2689cat 3005.993 kb on - strand, within Rv2689cat 3006.323 kb on + strand, within Rv2689cat 3006.323 kb on + strand, within Rv2689cat 3006.448 kb on - strand, within Rv2689cat 3006.512 kb on + strand, within Rv2689cat 3006.512 kb on + strand, within Rv2689cat 3006.513 kb on - strand, within Rv2689cat 3006.556 kb on + strand, within Rv2689cat 3006.614 kb on + strand, within Rv2689c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ciprofloxacin Hydrochloride 0.001 mM
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3,004,064 - -0.6
3,004,213 + Rv2687c 0.25 -0.4
3,004,214 - Rv2687c 0.25 +0.8
3,004,604 - Rv2687c 0.80 +0.4
3,004,662 - Rv2687c 0.88 -0.9
3,004,707 + -0.3
3,004,805 - -0.8
3,005,211 + Rv2688c 0.51 -0.1
3,005,212 - Rv2688c 0.52 -0.5
3,005,222 + Rv2688c 0.53 +0.5
3,005,223 - Rv2688c 0.53 +0.6
3,005,292 + Rv2688c 0.60 -0.3
3,005,293 - Rv2688c 0.60 +0.2
3,005,322 + Rv2688c 0.64 +0.4
3,005,380 - Rv2688c 0.70 +1.1
3,005,498 + Rv2688c 0.83 +0.5
3,005,499 - Rv2688c 0.83 -0.3
3,005,499 - Rv2688c 0.83 -0.6
3,005,730 + -0.2
3,005,772 + -0.2
3,005,772 + -0.5
3,005,773 - -0.1
3,005,775 + -0.0
3,005,775 + -0.7
3,005,789 + +0.0
3,005,790 - -2.2
3,005,847 - -0.9
3,005,847 - -0.9
3,005,882 + -0.3
3,005,882 + -0.2
3,005,883 - +1.1
3,005,883 - -0.4
3,005,988 + Rv2689c 0.12 -0.4
3,005,988 + Rv2689c 0.12 +0.1
3,005,988 + Rv2689c 0.12 -3.1
3,005,989 - Rv2689c 0.12 -0.2
3,005,989 - Rv2689c 0.12 +0.7
3,005,989 - Rv2689c 0.12 -0.0
3,005,989 - Rv2689c 0.12 +0.3
3,005,992 + Rv2689c 0.12 +0.9
3,005,992 + Rv2689c 0.12 +0.5
3,005,993 - Rv2689c 0.12 -0.3
3,005,993 - Rv2689c 0.12 +1.7
3,005,993 - Rv2689c 0.12 -0.1
3,005,993 - Rv2689c 0.12 +0.4
3,005,993 - Rv2689c 0.12 +0.0
3,005,993 - Rv2689c 0.12 +0.2
3,006,323 + Rv2689c 0.39 -0.4
3,006,323 + Rv2689c 0.39 +1.2
3,006,448 - Rv2689c 0.50 +1.0
3,006,512 + Rv2689c 0.55 -0.1
3,006,512 + Rv2689c 0.55 +1.0
3,006,513 - Rv2689c 0.55 -0.3
3,006,556 + Rv2689c 0.58 -0.3
3,006,614 + Rv2689c 0.63 +0.0

Or see this region's nucleotide sequence