Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1265

Experiment: 7H9 with Ciprofloxacin Hydrochloride 0.001 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1264 and Rv1265 are separated by 172 nucleotidesRv1265 and Rv1266c are separated by 19 nucleotides Rv1264: Rv1264 - Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase), at 1,411,894 to 1,413,087 Rv1264 Rv1265: Rv1265 - Unknown protein, at 1,413,260 to 1,413,940 Rv1265 Rv1266c: Rv1266c - Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H), at 1,413,960 to 1,415,840 Rv1266c Position (kb) 1413 1414Strain fitness (log2 ratio) -1 0 1at 1412.673 kb on + strand, within Rv1264at 1412.674 kb on - strand, within Rv1264at 1413.085 kb on + strandat 1413.085 kb on + strandat 1413.237 kb on - strandat 1413.237 kb on - strandat 1413.401 kb on + strand, within Rv1265at 1414.114 kb on - strandat 1414.166 kb on - strand, within Rv1266cat 1414.300 kb on + strand, within Rv1266cat 1414.301 kb on - strand, within Rv1266cat 1414.301 kb on - strand, within Rv1266cat 1414.361 kb on - strand, within Rv1266cat 1414.361 kb on - strand, within Rv1266cat 1414.381 kb on + strand, within Rv1266cat 1414.381 kb on + strand, within Rv1266cat 1414.515 kb on - strand, within Rv1266cat 1414.548 kb on + strand, within Rv1266cat 1414.714 kb on + strand, within Rv1266cat 1414.715 kb on - strand, within Rv1266cat 1414.717 kb on + strand, within Rv1266cat 1414.717 kb on + strand, within Rv1266cat 1414.834 kb on + strand, within Rv1266c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ciprofloxacin Hydrochloride 0.001 mM
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1,412,673 + Rv1264 0.65 +1.2
1,412,674 - Rv1264 0.65 +0.5
1,413,085 + -0.8
1,413,085 + -0.4
1,413,237 - -0.1
1,413,237 - -0.5
1,413,401 + Rv1265 0.21 -0.5
1,414,114 - +0.3
1,414,166 - Rv1266c 0.11 -0.5
1,414,300 + Rv1266c 0.18 -0.4
1,414,301 - Rv1266c 0.18 -0.5
1,414,301 - Rv1266c 0.18 +0.3
1,414,361 - Rv1266c 0.21 -0.6
1,414,361 - Rv1266c 0.21 -0.4
1,414,381 + Rv1266c 0.22 -1.5
1,414,381 + Rv1266c 0.22 -0.1
1,414,515 - Rv1266c 0.30 -0.3
1,414,548 + Rv1266c 0.31 -0.3
1,414,714 + Rv1266c 0.40 +1.6
1,414,715 - Rv1266c 0.40 -1.2
1,414,717 + Rv1266c 0.40 -0.3
1,414,717 + Rv1266c 0.40 -0.4
1,414,834 + Rv1266c 0.46 +0.1

Or see this region's nucleotide sequence