Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3015c

Experiment: 7H9 with Ciprofloxacin Hydrochloride 0.001 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3014c and Rv3015c are separated by 30 nucleotidesRv3015c and Rv3016 are separated by 93 nucleotidesRv3016 and Rv3017c are separated by 102 nucleotides Rv3014c: Rv3014c - DNA ligase [NAD dependent] LigA (polydeoxyribonucleotide synthase [NAD+]), at 3,372,545 to 3,374,620 Rv3014c Rv3015c: Rv3015c - Conserved hypothetical protein, at 3,374,651 to 3,375,664 Rv3015c Rv3016: Rv3016 - Probable lipoprotein LpqA, at 3,375,758 to 3,376,387 Rv3016 Rv3017c: Rv3017c - ESAT-6 like protein EsxQ (TB12.9) (ESAT-6 like protein 8), at 3,376,490 to 3,376,852 Rv3017c Position (kb) 3374 3375 3376Strain fitness (log2 ratio) -1 0 1 2at 3374.778 kb on - strand, within Rv3015cat 3375.400 kb on + strand, within Rv3015cat 3375.400 kb on + strand, within Rv3015cat 3375.561 kb on + strand, within Rv3015cat 3375.676 kb on - strandat 3375.786 kb on + strandat 3375.787 kb on - strandat 3375.787 kb on - strandat 3375.801 kb on + strandat 3375.802 kb on - strandat 3375.886 kb on + strand, within Rv3016at 3375.971 kb on + strand, within Rv3016at 3375.972 kb on - strand, within Rv3016at 3375.972 kb on - strand, within Rv3016at 3376.006 kb on - strand, within Rv3016at 3376.225 kb on + strand, within Rv3016at 3376.251 kb on + strand, within Rv3016at 3376.251 kb on + strand, within Rv3016at 3376.251 kb on + strand, within Rv3016at 3376.283 kb on + strand, within Rv3016at 3376.386 kb on - strandat 3376.626 kb on - strand, within Rv3017cat 3376.648 kb on - strand, within Rv3017c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ciprofloxacin Hydrochloride 0.001 mM
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3,374,778 - Rv3015c 0.13 -0.0
3,375,400 + Rv3015c 0.74 -0.3
3,375,400 + Rv3015c 0.74 -1.4
3,375,561 + Rv3015c 0.90 -1.4
3,375,676 - -0.8
3,375,786 + +0.7
3,375,787 - +0.2
3,375,787 - +0.3
3,375,801 + -0.1
3,375,802 - -1.2
3,375,886 + Rv3016 0.20 -0.5
3,375,971 + Rv3016 0.34 -0.7
3,375,972 - Rv3016 0.34 +1.8
3,375,972 - Rv3016 0.34 -0.9
3,376,006 - Rv3016 0.39 +1.1
3,376,225 + Rv3016 0.74 -0.7
3,376,251 + Rv3016 0.78 +1.1
3,376,251 + Rv3016 0.78 -0.7
3,376,251 + Rv3016 0.78 +1.8
3,376,283 + Rv3016 0.83 -0.5
3,376,386 - -0.6
3,376,626 - Rv3017c 0.37 +1.8
3,376,648 - Rv3017c 0.44 -0.5

Or see this region's nucleotide sequence