Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2602

Experiment: 7H9 with Ciprofloxacin Hydrochloride 0.001 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2601 and Rv2601A are separated by 110 nucleotidesRv2601A and Rv2602 overlap by 14 nucleotidesRv2602 and Rv2603c are separated by 20 nucleotidesRv2603c and Rv2604c are separated by 132 nucleotides Rv2601: Rv2601 - Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY), at 2,928,388 to 2,929,959 Rv2601 Rv2601A: Rv2601A - Possible antitoxin VapB41, at 2,930,070 to 2,930,357 Rv2601A Rv2602: Rv2602 - Possible toxin VapC41. Contains PIN domain., at 2,930,344 to 2,930,784 Rv2602 Rv2603c: Rv2603c - Highly conserved protein, at 2,930,805 to 2,931,560 Rv2603c Rv2604c: Rv2604c - Probable glutamine amidotransferase SnoP, at 2,931,693 to 2,932,289 Rv2604c Position (kb) 2930 2931Strain fitness (log2 ratio) -2 -1 0 1at 2929.463 kb on + strand, within Rv2601at 2929.464 kb on - strand, within Rv2601at 2929.464 kb on - strand, within Rv2601at 2929.464 kb on - strand, within Rv2601at 2929.464 kb on - strand, within Rv2601at 2929.583 kb on - strand, within Rv2601at 2929.597 kb on + strand, within Rv2601at 2929.597 kb on + strand, within Rv2601at 2929.597 kb on + strand, within Rv2601at 2929.598 kb on - strand, within Rv2601at 2929.598 kb on - strand, within Rv2601at 2929.598 kb on - strand, within Rv2601at 2929.661 kb on - strand, within Rv2601at 2929.730 kb on - strand, within Rv2601at 2929.730 kb on - strand, within Rv2601at 2929.782 kb on + strand, within Rv2601at 2929.782 kb on + strand, within Rv2601at 2929.957 kb on + strandat 2929.970 kb on + strandat 2929.970 kb on + strandat 2930.049 kb on + strandat 2930.423 kb on + strand, within Rv2602at 2930.519 kb on - strand, within Rv2602at 2930.683 kb on + strand, within Rv2602at 2930.684 kb on - strand, within Rv2602at 2930.684 kb on - strand, within Rv2602at 2930.684 kb on - strand, within Rv2602at 2930.684 kb on - strand, within Rv2602at 2930.687 kb on + strand, within Rv2602at 2930.687 kb on + strand, within Rv2602at 2930.703 kb on + strand, within Rv2602at 2930.704 kb on - strand, within Rv2602at 2930.749 kb on + strandat 2930.750 kb on - strandat 2931.604 kb on + strandat 2931.604 kb on + strandat 2931.604 kb on + strandat 2931.604 kb on + strandat 2931.605 kb on - strandat 2931.605 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ciprofloxacin Hydrochloride 0.001 mM
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2,929,463 + Rv2601 0.68 -0.5
2,929,464 - Rv2601 0.68 +0.6
2,929,464 - Rv2601 0.68 -0.1
2,929,464 - Rv2601 0.68 -1.3
2,929,464 - Rv2601 0.68 -0.5
2,929,583 - Rv2601 0.76 -0.4
2,929,597 + Rv2601 0.77 -0.7
2,929,597 + Rv2601 0.77 -0.0
2,929,597 + Rv2601 0.77 +0.5
2,929,598 - Rv2601 0.77 -0.2
2,929,598 - Rv2601 0.77 -0.1
2,929,598 - Rv2601 0.77 +1.1
2,929,661 - Rv2601 0.81 -1.9
2,929,730 - Rv2601 0.85 +0.0
2,929,730 - Rv2601 0.85 +0.6
2,929,782 + Rv2601 0.89 +0.6
2,929,782 + Rv2601 0.89 -1.9
2,929,957 + +0.7
2,929,970 + -1.1
2,929,970 + -0.4
2,930,049 + -0.9
2,930,423 + Rv2602 0.18 -0.0
2,930,519 - Rv2602 0.40 -0.6
2,930,683 + Rv2602 0.77 -2.5
2,930,684 - Rv2602 0.77 -0.3
2,930,684 - Rv2602 0.77 -0.6
2,930,684 - Rv2602 0.77 -1.2
2,930,684 - Rv2602 0.77 -0.6
2,930,687 + Rv2602 0.78 +0.5
2,930,687 + Rv2602 0.78 +0.8
2,930,703 + Rv2602 0.81 -0.4
2,930,704 - Rv2602 0.82 -1.4
2,930,749 + -0.7
2,930,750 - -0.2
2,931,604 + +0.5
2,931,604 + -1.2
2,931,604 + +1.2
2,931,604 + -0.5
2,931,605 - -1.7
2,931,605 - -0.5

Or see this region's nucleotide sequence