Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2411c

Experiment: 7H9 with Ciprofloxacin Hydrochloride 0.001 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2409c and Rv2410c overlap by 1 nucleotidesRv2410c and Rv2411c overlap by 1 nucleotidesRv2411c and Rv2412 are separated by 109 nucleotidesRv2412 and Rv2413c are separated by 15 nucleotides Rv2409c: Rv2409c - Conserved protein, at 2,706,494 to 2,707,333 Rv2409c Rv2410c: Rv2410c - Conserved protein, at 2,707,333 to 2,708,310 Rv2410c Rv2411c: Rv2411c - Conserved hypothetical protein, at 2,708,310 to 2,709,965 Rv2411c Rv2412: Rv2412 - 30S ribosomal protein S20 RpsT, at 2,710,075 to 2,710,335 Rv2412 Rv2413c: Rv2413c - Conserved hypothetical protein, at 2,710,351 to 2,711,301 Rv2413c Position (kb) 2708 2709 2710Strain fitness (log2 ratio) -3 -2 -1 0 1 2 3at 2707.712 kb on + strand, within Rv2410cat 2707.712 kb on + strand, within Rv2410cat 2707.712 kb on + strand, within Rv2410cat 2707.976 kb on + strand, within Rv2410cat 2707.976 kb on + strand, within Rv2410cat 2708.283 kb on - strandat 2708.371 kb on + strandat 2708.571 kb on + strand, within Rv2411cat 2708.571 kb on + strand, within Rv2411cat 2708.571 kb on + strand, within Rv2411cat 2708.572 kb on - strand, within Rv2411cat 2708.572 kb on - strand, within Rv2411cat 2708.572 kb on - strand, within Rv2411cat 2708.890 kb on + strand, within Rv2411cat 2708.890 kb on + strand, within Rv2411cat 2708.890 kb on + strand, within Rv2411cat 2708.891 kb on - strand, within Rv2411cat 2708.891 kb on - strand, within Rv2411cat 2708.893 kb on + strand, within Rv2411cat 2708.894 kb on - strand, within Rv2411cat 2708.914 kb on + strand, within Rv2411cat 2708.914 kb on + strand, within Rv2411cat 2708.914 kb on + strand, within Rv2411cat 2708.914 kb on + strand, within Rv2411cat 2708.914 kb on + strand, within Rv2411cat 2708.914 kb on + strand, within Rv2411cat 2708.915 kb on - strand, within Rv2411cat 2708.915 kb on - strand, within Rv2411cat 2709.071 kb on - strand, within Rv2411cat 2709.112 kb on + strand, within Rv2411cat 2709.112 kb on + strand, within Rv2411cat 2709.112 kb on + strand, within Rv2411cat 2709.112 kb on + strand, within Rv2411cat 2709.113 kb on - strand, within Rv2411cat 2709.113 kb on - strand, within Rv2411cat 2709.113 kb on - strand, within Rv2411cat 2709.113 kb on - strand, within Rv2411cat 2709.113 kb on - strand, within Rv2411cat 2709.113 kb on - strand, within Rv2411cat 2709.113 kb on - strand, within Rv2411cat 2709.113 kb on - strand, within Rv2411cat 2709.113 kb on - strand, within Rv2411cat 2709.114 kb on + strand, within Rv2411cat 2709.114 kb on + strand, within Rv2411cat 2709.115 kb on - strand, within Rv2411cat 2709.115 kb on - strand, within Rv2411cat 2709.208 kb on + strand, within Rv2411cat 2709.209 kb on - strand, within Rv2411cat 2709.209 kb on - strand, within Rv2411cat 2709.295 kb on + strand, within Rv2411cat 2709.296 kb on - strand, within Rv2411cat 2709.296 kb on - strand, within Rv2411cat 2709.376 kb on + strand, within Rv2411cat 2709.376 kb on + strand, within Rv2411cat 2709.377 kb on - strand, within Rv2411cat 2709.377 kb on - strand, within Rv2411cat 2709.377 kb on - strand, within Rv2411cat 2709.577 kb on + strand, within Rv2411cat 2709.577 kb on + strand, within Rv2411cat 2709.577 kb on + strand, within Rv2411cat 2709.578 kb on - strand, within Rv2411cat 2709.578 kb on - strand, within Rv2411cat 2709.592 kb on + strand, within Rv2411cat 2709.593 kb on - strand, within Rv2411cat 2709.593 kb on - strand, within Rv2411cat 2709.799 kb on + strand, within Rv2411cat 2709.799 kb on + strand, within Rv2411cat 2709.799 kb on + strand, within Rv2411cat 2709.799 kb on + strand, within Rv2411cat 2709.803 kb on + strandat 2709.803 kb on + strandat 2709.865 kb on + strandat 2709.883 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ciprofloxacin Hydrochloride 0.001 mM
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2,707,712 + Rv2410c 0.39 +1.8
2,707,712 + Rv2410c 0.39 -0.8
2,707,712 + Rv2410c 0.39 -0.5
2,707,976 + Rv2410c 0.66 -0.4
2,707,976 + Rv2410c 0.66 +0.0
2,708,283 - +0.5
2,708,371 + -0.6
2,708,571 + Rv2411c 0.16 -1.8
2,708,571 + Rv2411c 0.16 +0.0
2,708,571 + Rv2411c 0.16 -0.4
2,708,572 - Rv2411c 0.16 +0.6
2,708,572 - Rv2411c 0.16 +0.1
2,708,572 - Rv2411c 0.16 +1.8
2,708,890 + Rv2411c 0.35 -0.2
2,708,890 + Rv2411c 0.35 -0.3
2,708,890 + Rv2411c 0.35 +0.1
2,708,891 - Rv2411c 0.35 +0.7
2,708,891 - Rv2411c 0.35 -2.9
2,708,893 + Rv2411c 0.35 +0.0
2,708,894 - Rv2411c 0.35 +0.0
2,708,914 + Rv2411c 0.36 -0.3
2,708,914 + Rv2411c 0.36 +0.6
2,708,914 + Rv2411c 0.36 +0.9
2,708,914 + Rv2411c 0.36 +1.1
2,708,914 + Rv2411c 0.36 +3.4
2,708,914 + Rv2411c 0.36 +0.4
2,708,915 - Rv2411c 0.37 -0.7
2,708,915 - Rv2411c 0.37 +0.0
2,709,071 - Rv2411c 0.46 -0.7
2,709,112 + Rv2411c 0.48 +0.1
2,709,112 + Rv2411c 0.48 -0.3
2,709,112 + Rv2411c 0.48 +0.4
2,709,112 + Rv2411c 0.48 -0.2
2,709,113 - Rv2411c 0.48 +0.3
2,709,113 - Rv2411c 0.48 -0.1
2,709,113 - Rv2411c 0.48 -0.0
2,709,113 - Rv2411c 0.48 -0.1
2,709,113 - Rv2411c 0.48 +1.8
2,709,113 - Rv2411c 0.48 +1.1
2,709,113 - Rv2411c 0.48 -0.3
2,709,113 - Rv2411c 0.48 +0.2
2,709,113 - Rv2411c 0.48 -0.7
2,709,114 + Rv2411c 0.49 +0.8
2,709,114 + Rv2411c 0.49 +0.0
2,709,115 - Rv2411c 0.49 -0.2
2,709,115 - Rv2411c 0.49 -0.2
2,709,208 + Rv2411c 0.54 -0.6
2,709,209 - Rv2411c 0.54 -1.2
2,709,209 - Rv2411c 0.54 +0.1
2,709,295 + Rv2411c 0.59 -1.4
2,709,296 - Rv2411c 0.60 +0.3
2,709,296 - Rv2411c 0.60 +2.9
2,709,376 + Rv2411c 0.64 -1.8
2,709,376 + Rv2411c 0.64 -0.5
2,709,377 - Rv2411c 0.64 -0.4
2,709,377 - Rv2411c 0.64 -1.0
2,709,377 - Rv2411c 0.64 +0.2
2,709,577 + Rv2411c 0.77 +1.5
2,709,577 + Rv2411c 0.77 +0.1
2,709,577 + Rv2411c 0.77 +0.6
2,709,578 - Rv2411c 0.77 +0.4
2,709,578 - Rv2411c 0.77 +1.2
2,709,592 + Rv2411c 0.77 +0.8
2,709,593 - Rv2411c 0.77 -1.3
2,709,593 - Rv2411c 0.77 +0.8
2,709,799 + Rv2411c 0.90 +0.8
2,709,799 + Rv2411c 0.90 -0.2
2,709,799 + Rv2411c 0.90 -0.3
2,709,799 + Rv2411c 0.90 -0.1
2,709,803 + +3.4
2,709,803 + -2.2
2,709,865 + -0.1
2,709,883 + -0.0

Or see this region's nucleotide sequence