Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2329c

Experiment: 7H9 with Ciprofloxacin Hydrochloride 0.001 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2328 and Rv2329c are separated by 34 nucleotidesRv2329c and Rv2330c are separated by 233 nucleotidesRv2330c and Rv2331 are separated by 74 nucleotides Rv2328: Rv2328 - PE family protein PE23, at 2,600,731 to 2,601,879 Rv2328 Rv2329c: Rv2329c - Probable nitrite extrusion protein 1 NarK1 (nitrite facilitator 1), at 2,601,914 to 2,603,461 Rv2329c Rv2330c: Rv2330c - Probable lipoprotein LppP, at 2,603,695 to 2,604,222 Rv2330c Rv2331: Rv2331 - Hypothetical protein, at 2,604,297 to 2,604,683 Rv2331 Position (kb) 2601 2602 2603 2604Strain fitness (log2 ratio) -1 0 1 2 3at 2601.418 kb on - strand, within Rv2328at 2601.418 kb on - strand, within Rv2328at 2601.638 kb on + strand, within Rv2328at 2601.786 kb on - strandat 2601.878 kb on - strandat 2602.048 kb on - strandat 2602.080 kb on + strand, within Rv2329cat 2602.080 kb on + strand, within Rv2329cat 2602.080 kb on + strand, within Rv2329cat 2602.081 kb on - strand, within Rv2329cat 2602.132 kb on - strand, within Rv2329cat 2602.202 kb on + strand, within Rv2329cat 2602.202 kb on + strand, within Rv2329cat 2602.353 kb on + strand, within Rv2329cat 2602.454 kb on + strand, within Rv2329cat 2602.454 kb on + strand, within Rv2329cat 2602.455 kb on - strand, within Rv2329cat 2602.456 kb on + strand, within Rv2329cat 2602.504 kb on - strand, within Rv2329cat 2602.504 kb on - strand, within Rv2329cat 2602.806 kb on + strand, within Rv2329cat 2602.806 kb on + strand, within Rv2329cat 2602.806 kb on + strand, within Rv2329cat 2602.868 kb on + strand, within Rv2329cat 2602.869 kb on - strand, within Rv2329cat 2602.869 kb on - strand, within Rv2329cat 2602.945 kb on - strand, within Rv2329cat 2603.142 kb on + strand, within Rv2329cat 2603.271 kb on + strand, within Rv2329cat 2603.272 kb on - strand, within Rv2329cat 2603.348 kb on + strandat 2603.348 kb on + strandat 2603.526 kb on + strandat 2603.527 kb on - strandat 2603.571 kb on + strandat 2603.624 kb on + strandat 2603.631 kb on + strandat 2603.631 kb on + strandat 2603.632 kb on - strandat 2603.632 kb on - strandat 2603.637 kb on + strandat 2603.638 kb on - strandat 2603.681 kb on - strandat 2603.681 kb on - strandat 2603.693 kb on + strandat 2603.696 kb on + strandat 2603.697 kb on - strandat 2603.811 kb on - strand, within Rv2330cat 2603.855 kb on + strand, within Rv2330cat 2603.855 kb on + strand, within Rv2330cat 2603.856 kb on - strand, within Rv2330cat 2603.982 kb on + strand, within Rv2330cat 2603.983 kb on - strand, within Rv2330cat 2604.052 kb on + strand, within Rv2330cat 2604.307 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ciprofloxacin Hydrochloride 0.001 mM
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2,601,418 - Rv2328 0.60 +1.2
2,601,418 - Rv2328 0.60 -0.5
2,601,638 + Rv2328 0.79 -0.2
2,601,786 - -0.4
2,601,878 - -0.3
2,602,048 - -0.7
2,602,080 + Rv2329c 0.11 +2.8
2,602,080 + Rv2329c 0.11 +0.1
2,602,080 + Rv2329c 0.11 -1.7
2,602,081 - Rv2329c 0.11 -0.3
2,602,132 - Rv2329c 0.14 +0.5
2,602,202 + Rv2329c 0.19 +0.7
2,602,202 + Rv2329c 0.19 -0.2
2,602,353 + Rv2329c 0.28 -0.2
2,602,454 + Rv2329c 0.35 +0.3
2,602,454 + Rv2329c 0.35 +0.7
2,602,455 - Rv2329c 0.35 +1.8
2,602,456 + Rv2329c 0.35 -0.5
2,602,504 - Rv2329c 0.38 -0.1
2,602,504 - Rv2329c 0.38 -0.3
2,602,806 + Rv2329c 0.58 +1.3
2,602,806 + Rv2329c 0.58 -0.7
2,602,806 + Rv2329c 0.58 +0.2
2,602,868 + Rv2329c 0.62 +0.2
2,602,869 - Rv2329c 0.62 +1.3
2,602,869 - Rv2329c 0.62 +1.8
2,602,945 - Rv2329c 0.67 -0.0
2,603,142 + Rv2329c 0.79 -0.0
2,603,271 + Rv2329c 0.88 -0.2
2,603,272 - Rv2329c 0.88 +1.4
2,603,348 + -0.6
2,603,348 + -0.3
2,603,526 + -0.4
2,603,527 - +0.1
2,603,571 + -1.7
2,603,624 + -0.9
2,603,631 + +0.8
2,603,631 + -0.3
2,603,632 - +0.2
2,603,632 - +0.7
2,603,637 + -0.6
2,603,638 - +0.1
2,603,681 - +0.4
2,603,681 - -0.8
2,603,693 + +0.1
2,603,696 + -0.4
2,603,697 - +0.5
2,603,811 - Rv2330c 0.22 -0.5
2,603,855 + Rv2330c 0.30 -0.4
2,603,855 + Rv2330c 0.30 +0.0
2,603,856 - Rv2330c 0.30 +1.8
2,603,982 + Rv2330c 0.54 +0.6
2,603,983 - Rv2330c 0.55 +0.1
2,604,052 + Rv2330c 0.68 -0.7
2,604,307 + +2.4

Or see this region's nucleotide sequence