Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1393c

Experiment: 7H9 with Ciprofloxacin Hydrochloride 0.001 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1392 and Rv1393c are separated by 72 nucleotidesRv1393c and Rv1394c overlap by 4 nucleotides Rv1392: Rv1392 - Probable S-adenosylmethionine synthetase MetK (mat) (AdoMet synthetase) (methionine adenosyltransferase), at 1,566,825 to 1,568,036 Rv1392 Rv1393c: Rv1393c - Probable monoxygenase, at 1,568,109 to 1,569,587 Rv1393c Rv1394c: Rv1394c - Probable cytochrome P450 132 Cyp132, at 1,569,584 to 1,570,969 Rv1394c Position (kb) 1568 1569 1570Strain fitness (log2 ratio) -1 0 1 2 3 4at 1568.111 kb on - strandat 1568.159 kb on - strandat 1568.215 kb on + strandat 1568.215 kb on + strandat 1568.216 kb on - strandat 1568.216 kb on - strandat 1568.288 kb on - strand, within Rv1393cat 1568.288 kb on - strand, within Rv1393cat 1568.416 kb on + strand, within Rv1393cat 1568.416 kb on + strand, within Rv1393cat 1568.417 kb on - strand, within Rv1393cat 1568.470 kb on + strand, within Rv1393cat 1568.470 kb on + strand, within Rv1393cat 1568.470 kb on + strand, within Rv1393cat 1568.536 kb on + strand, within Rv1393cat 1568.560 kb on - strand, within Rv1393cat 1568.698 kb on + strand, within Rv1393cat 1568.698 kb on + strand, within Rv1393cat 1568.698 kb on + strand, within Rv1393cat 1568.738 kb on - strand, within Rv1393cat 1569.313 kb on + strand, within Rv1393cat 1569.314 kb on - strand, within Rv1393cat 1569.364 kb on + strand, within Rv1393cat 1569.365 kb on - strand, within Rv1393cat 1569.406 kb on + strand, within Rv1393cat 1569.422 kb on + strand, within Rv1393cat 1569.496 kb on + strandat 1569.496 kb on + strandat 1569.608 kb on + strandat 1569.608 kb on + strandat 1569.775 kb on - strand, within Rv1394cat 1570.350 kb on + strand, within Rv1394cat 1570.354 kb on + strand, within Rv1394cat 1570.354 kb on + strand, within Rv1394cat 1570.354 kb on + strand, within Rv1394cat 1570.355 kb on - strand, within Rv1394cat 1570.355 kb on - strand, within Rv1394c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ciprofloxacin Hydrochloride 0.001 mM
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1,568,111 - -0.3
1,568,159 - -1.0
1,568,215 + -1.1
1,568,215 + +1.5
1,568,216 - -0.1
1,568,216 - -0.4
1,568,288 - Rv1393c 0.12 -0.2
1,568,288 - Rv1393c 0.12 +0.2
1,568,416 + Rv1393c 0.21 -1.5
1,568,416 + Rv1393c 0.21 -0.3
1,568,417 - Rv1393c 0.21 +1.0
1,568,470 + Rv1393c 0.24 -1.3
1,568,470 + Rv1393c 0.24 -0.2
1,568,470 + Rv1393c 0.24 +0.4
1,568,536 + Rv1393c 0.29 -0.2
1,568,560 - Rv1393c 0.30 -0.5
1,568,698 + Rv1393c 0.40 +0.5
1,568,698 + Rv1393c 0.40 +0.5
1,568,698 + Rv1393c 0.40 +1.5
1,568,738 - Rv1393c 0.43 +0.2
1,569,313 + Rv1393c 0.81 +1.0
1,569,314 - Rv1393c 0.81 -0.4
1,569,364 + Rv1393c 0.85 +0.4
1,569,365 - Rv1393c 0.85 +3.9
1,569,406 + Rv1393c 0.88 +0.9
1,569,422 + Rv1393c 0.89 -0.2
1,569,496 + +0.1
1,569,496 + -0.3
1,569,608 + +0.4
1,569,608 + -0.3
1,569,775 - Rv1394c 0.14 -0.5
1,570,350 + Rv1394c 0.55 +1.1
1,570,354 + Rv1394c 0.56 -1.7
1,570,354 + Rv1394c 0.56 +0.0
1,570,354 + Rv1394c 0.56 -0.0
1,570,355 - Rv1394c 0.56 -1.5
1,570,355 - Rv1394c 0.56 +0.9

Or see this region's nucleotide sequence