Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1084

Experiment: 7H9 with Ciprofloxacin Hydrochloride 0.001 mM

Add experiment(s):

Zoom: Pan:

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

download SVG
500 ntRv1082 and Rv1083 overlap by 4 nucleotidesRv1083 and Rv1084 overlap by 14 nucleotidesRv1084 and Rv1085c are separated by 98 nucleotidesRv1085c and Rv1086 are separated by 110 nucleotides Rv1082: Rv1082 - Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase), at 1,206,520 to 1,207,386 Rv1082 Rv1083: Rv1083 - Conserved hypothetical protein, at 1,207,383 to 1,207,649 Rv1083 Rv1084: Rv1084 - Conserved protein, at 1,207,636 to 1,209,657 Rv1084 Rv1085c: Rv1085c - Possible hemolysin-like protein, at 1,209,756 to 1,210,484 Rv1085c Rv1086: Rv1086 - Short (C15) chain Z-isoprenyl diphosphate synthase (Z-FPP synthase) (Z-farnesyl diphosphate synthase) (Z-FPP synthetase) (Z-farnesyl diphosphate synthetase) (geranyltranstransferase) (farnesyl pyrophosphate synthetase), at 1,210,595 to 1,211,383 Rv1086 Position (kb) 1207 1208 1209 1210Strain fitness (log2 ratio) -2 -1 0 1at 1206.789 kb on - strand, within Rv1082at 1206.792 kb on + strand, within Rv1082at 1206.793 kb on - strand, within Rv1082at 1206.803 kb on + strand, within Rv1082at 1206.910 kb on + strand, within Rv1082at 1207.042 kb on + strand, within Rv1082at 1207.042 kb on + strand, within Rv1082at 1207.045 kb on + strand, within Rv1082at 1207.046 kb on - strand, within Rv1082at 1207.335 kb on + strandat 1207.648 kb on - strandat 1207.691 kb on - strandat 1207.710 kb on + strandat 1207.927 kb on + strand, within Rv1084at 1207.928 kb on - strand, within Rv1084at 1207.928 kb on - strand, within Rv1084at 1208.021 kb on - strand, within Rv1084at 1208.282 kb on + strand, within Rv1084at 1208.294 kb on - strand, within Rv1084at 1208.369 kb on - strand, within Rv1084at 1208.369 kb on - strand, within Rv1084at 1208.446 kb on + strand, within Rv1084at 1208.630 kb on - strand, within Rv1084at 1208.630 kb on - strand, within Rv1084at 1209.073 kb on + strand, within Rv1084at 1209.577 kb on + strandat 1209.577 kb on + strandat 1209.577 kb on + strandat 1209.578 kb on - strandat 1209.581 kb on + strandat 1209.867 kb on + strand, within Rv1085cat 1209.874 kb on + strand, within Rv1085cat 1209.875 kb on - strand, within Rv1085cat 1209.964 kb on + strand, within Rv1085cat 1209.994 kb on + strand, within Rv1085cat 1209.995 kb on - strand, within Rv1085cat 1210.133 kb on - strand, within Rv1085cat 1210.133 kb on - strand, within Rv1085cat 1210.133 kb on - strand, within Rv1085cat 1210.222 kb on + strand, within Rv1085cat 1210.264 kb on + strand, within Rv1085cat 1210.358 kb on - strand, within Rv1085cat 1210.535 kb on + strandat 1210.581 kb on + strandat 1210.581 kb on + strandat 1210.581 kb on + strandat 1210.582 kb on - strandat 1210.640 kb on + strand

download strain data

Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ciprofloxacin Hydrochloride 0.001 mM
remove
1,206,789 - Rv1082 0.31 +1.3
1,206,792 + Rv1082 0.31 +0.0
1,206,793 - Rv1082 0.31 -0.5
1,206,803 + Rv1082 0.33 +0.3
1,206,910 + Rv1082 0.45 -0.2
1,207,042 + Rv1082 0.60 +0.2
1,207,042 + Rv1082 0.60 -0.5
1,207,045 + Rv1082 0.61 -0.2
1,207,046 - Rv1082 0.61 -0.8
1,207,335 + +0.2
1,207,648 - -0.1
1,207,691 - -0.2
1,207,710 + +1.2
1,207,927 + Rv1084 0.14 +0.0
1,207,928 - Rv1084 0.14 +0.8
1,207,928 - Rv1084 0.14 +0.3
1,208,021 - Rv1084 0.19 +0.2
1,208,282 + Rv1084 0.32 +0.1
1,208,294 - Rv1084 0.33 -0.6
1,208,369 - Rv1084 0.36 -0.0
1,208,369 - Rv1084 0.36 +0.2
1,208,446 + Rv1084 0.40 +0.8
1,208,630 - Rv1084 0.49 +0.2
1,208,630 - Rv1084 0.49 +0.4
1,209,073 + Rv1084 0.71 +0.7
1,209,577 + +0.6
1,209,577 + -0.5
1,209,577 + +1.3
1,209,578 - -0.5
1,209,581 + +0.7
1,209,867 + Rv1085c 0.15 +0.2
1,209,874 + Rv1085c 0.16 +0.3
1,209,875 - Rv1085c 0.16 +0.8
1,209,964 + Rv1085c 0.29 +0.4
1,209,994 + Rv1085c 0.33 -0.3
1,209,995 - Rv1085c 0.33 +0.8
1,210,133 - Rv1085c 0.52 +0.0
1,210,133 - Rv1085c 0.52 -0.4
1,210,133 - Rv1085c 0.52 +1.2
1,210,222 + Rv1085c 0.64 +0.1
1,210,264 + Rv1085c 0.70 +0.4
1,210,358 - Rv1085c 0.83 +1.1
1,210,535 + +1.2
1,210,581 + -0.4
1,210,581 + +0.2
1,210,581 + -1.2
1,210,582 - +0.4
1,210,640 + -1.8

Or see this region's nucleotide sequence