Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0663

Experiment: 7H9 with Ciprofloxacin Hydrochloride 0.001 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0660c and Rv0661c are separated by 109 nucleotidesRv0661c and Rv0662c overlap by 4 nucleotidesRv0662c and Rv0663 are separated by 113 nucleotidesRv0663 and Rv0664 are separated by 31 nucleotidesRv0664 and Rv0665 overlap by 4 nucleotidesRv0665 and Rv0666 overlap by 4 nucleotides Rv0660c: Rv0660c - Possible antitoxin MazE2, at 754,980 to 755,225 Rv0660c Rv0661c: Rv0661c - Possible toxin VapC7, at 755,335 to 755,772 Rv0661c Rv0662c: Rv0662c - Possible antitoxin VapB7, at 755,769 to 756,023 Rv0662c Rv0663: Rv0663 - Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase), at 756,137 to 758,500 Rv0663 Rv0664: Rv0664 - Possible antitoxin VapB8, at 758,532 to 758,804 Rv0664 Rv0665: Rv0665 - Possible toxin VapC8, at 758,801 to 759,139 Rv0665 Rv0666: Rv0666 - Possible membrane protein, at 759,136 to 759,309 Rv0666 Position (kb) 756 757 758 759Strain fitness (log2 ratio) -1 0 1 2at 755.249 kb on + strandat 755.249 kb on + strandat 755.250 kb on - strandat 755.250 kb on - strandat 755.250 kb on - strandat 755.280 kb on - strandat 755.280 kb on - strandat 755.280 kb on - strandat 755.311 kb on + strandat 755.311 kb on + strandat 755.572 kb on - strand, within Rv0661cat 755.623 kb on + strand, within Rv0661cat 755.767 kb on + strandat 755.768 kb on - strandat 756.023 kb on + strandat 756.023 kb on + strandat 756.029 kb on + strandat 756.030 kb on - strandat 756.112 kb on + strandat 756.122 kb on + strandat 756.197 kb on + strandat 756.197 kb on + strandat 756.707 kb on + strand, within Rv0663at 756.842 kb on + strand, within Rv0663at 756.843 kb on - strand, within Rv0663at 756.903 kb on - strand, within Rv0663at 757.173 kb on - strand, within Rv0663at 757.316 kb on + strand, within Rv0663at 757.317 kb on - strand, within Rv0663at 757.327 kb on + strand, within Rv0663at 757.327 kb on + strand, within Rv0663at 757.528 kb on - strand, within Rv0663at 757.577 kb on + strand, within Rv0663at 757.653 kb on - strand, within Rv0663at 758.117 kb on + strand, within Rv0663at 758.123 kb on + strand, within Rv0663at 758.151 kb on - strand, within Rv0663at 758.787 kb on - strandat 758.832 kb on + strandat 758.837 kb on - strand, within Rv0665at 758.908 kb on + strand, within Rv0665at 759.410 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ciprofloxacin Hydrochloride 0.001 mM
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755,249 + +0.7
755,249 + +0.2
755,250 - -0.9
755,250 - -1.6
755,250 - +0.3
755,280 - +1.7
755,280 - -0.5
755,280 - -0.1
755,311 + -0.3
755,311 + -0.3
755,572 - Rv0661c 0.54 +0.3
755,623 + Rv0661c 0.66 -0.7
755,767 + -0.4
755,768 - -0.7
756,023 + +0.3
756,023 + -0.1
756,029 + -0.4
756,030 - -1.3
756,112 + +1.0
756,122 + +0.7
756,197 + -0.7
756,197 + -0.6
756,707 + Rv0663 0.24 +1.1
756,842 + Rv0663 0.30 +0.5
756,843 - Rv0663 0.30 -0.1
756,903 - Rv0663 0.32 +0.9
757,173 - Rv0663 0.44 -0.2
757,316 + Rv0663 0.50 +0.7
757,317 - Rv0663 0.50 +1.1
757,327 + Rv0663 0.50 +1.0
757,327 + Rv0663 0.50 +0.0
757,528 - Rv0663 0.59 -1.5
757,577 + Rv0663 0.61 -0.5
757,653 - Rv0663 0.64 -0.2
758,117 + Rv0663 0.84 -0.3
758,123 + Rv0663 0.84 -0.2
758,151 - Rv0663 0.85 +1.2
758,787 - -0.7
758,832 + +1.9
758,837 - Rv0665 0.11 -0.5
758,908 + Rv0665 0.32 +0.1
759,410 + -0.4

Or see this region's nucleotide sequence