Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0652

Experiment: 7H9 with Ciprofloxacin Hydrochloride 0.001 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0650 and Rv0651 are separated by 330 nucleotidesRv0651 and Rv0652 are separated by 36 nucleotidesRv0652 and Rv0653c overlap by 8 nucleotidesRv0653c and Rv0654 are separated by 70 nucleotides Rv0650: Rv0650 - Possible sugar kinase, at 747,037 to 747,945 Rv0650 Rv0651: Rv0651 - 50S ribosomal protein L10 RplJ, at 748,276 to 748,812 Rv0651 Rv0652: Rv0652 - 50S ribosomal protein L7/L12 RplL (SA1), at 748,849 to 749,241 Rv0652 Rv0653c: Rv0653c - Possible transcriptional regulatory protein (probably TetR-family), at 749,234 to 749,929 Rv0653c Rv0654: Rv0654 - Probable dioxygenase, at 750,000 to 751,505 Rv0654 Position (kb) 748 749 750Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 747.943 kb on + strandat 748.010 kb on - strandat 748.047 kb on + strandat 749.239 kb on + strandat 749.240 kb on - strandat 749.447 kb on + strand, within Rv0653cat 749.447 kb on + strand, within Rv0653cat 749.447 kb on + strand, within Rv0653cat 749.448 kb on - strand, within Rv0653cat 749.448 kb on - strand, within Rv0653cat 749.634 kb on + strand, within Rv0653cat 749.634 kb on + strand, within Rv0653cat 749.635 kb on - strand, within Rv0653cat 749.744 kb on + strand, within Rv0653cat 749.744 kb on + strand, within Rv0653cat 749.800 kb on - strand, within Rv0653cat 750.073 kb on + strandat 750.073 kb on + strandat 750.073 kb on + strandat 750.074 kb on - strandat 750.074 kb on - strandat 750.130 kb on - strandat 750.130 kb on - strandat 750.138 kb on - strandat 750.177 kb on + strand, within Rv0654at 750.177 kb on + strand, within Rv0654at 750.178 kb on - strand, within Rv0654

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ciprofloxacin Hydrochloride 0.001 mM
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747,943 + -2.0
748,010 - -0.6
748,047 + -0.8
749,239 + +2.7
749,240 - -1.1
749,447 + Rv0653c 0.31 -1.4
749,447 + Rv0653c 0.31 -0.6
749,447 + Rv0653c 0.31 -0.2
749,448 - Rv0653c 0.31 -1.1
749,448 - Rv0653c 0.31 -2.0
749,634 + Rv0653c 0.57 -3.6
749,634 + Rv0653c 0.57 -0.3
749,635 - Rv0653c 0.58 -0.5
749,744 + Rv0653c 0.73 -0.6
749,744 + Rv0653c 0.73 -0.4
749,800 - Rv0653c 0.81 -0.9
750,073 + -0.5
750,073 + +0.1
750,073 + +0.1
750,074 - +0.1
750,074 - +0.9
750,130 - -1.0
750,130 - -0.8
750,138 - -0.1
750,177 + Rv0654 0.12 -0.4
750,177 + Rv0654 0.12 -0.5
750,178 - Rv0654 0.12 -0.8

Or see this region's nucleotide sequence