Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0633c

Experiment: 7H9 with Ciprofloxacin Hydrochloride 0.001 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0632c and Rv0633c are separated by 48 nucleotidesRv0633c and Rv0634c are separated by 153 nucleotidesRv0634c and Rv0634A are separated by 79 nucleotides Rv0632c: Rv0632c - Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase), at 728,583 to 729,278 Rv0632c Rv0633c: Rv0633c - Possible exported protein, at 729,327 to 730,166 Rv0633c Rv0634c: Rv0634c - Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II), at 730,320 to 731,033 Rv0634c Rv0634A: Rv0634A - Unknown protein, at 731,113 to 731,364 Rv0634A Position (kb) 729 730 731Strain fitness (log2 ratio) -2 -1 0 1 2at 728.360 kb on - strandat 728.360 kb on - strandat 728.360 kb on - strandat 728.540 kb on + strandat 728.585 kb on - strandat 728.908 kb on + strand, within Rv0632cat 728.909 kb on - strand, within Rv0632cat 729.020 kb on - strand, within Rv0632cat 729.257 kb on + strandat 729.260 kb on - strandat 729.260 kb on - strandat 729.328 kb on + strandat 729.508 kb on + strand, within Rv0633cat 729.508 kb on + strand, within Rv0633cat 729.521 kb on + strand, within Rv0633cat 729.522 kb on - strand, within Rv0633cat 729.522 kb on - strand, within Rv0633cat 729.522 kb on - strand, within Rv0633cat 729.525 kb on + strand, within Rv0633cat 729.526 kb on - strand, within Rv0633cat 729.691 kb on + strand, within Rv0633cat 729.692 kb on - strand, within Rv0633cat 729.694 kb on + strand, within Rv0633cat 729.695 kb on - strand, within Rv0633cat 729.838 kb on + strand, within Rv0633cat 729.905 kb on - strand, within Rv0633cat 729.934 kb on - strand, within Rv0633cat 729.989 kb on - strand, within Rv0633cat 729.989 kb on - strand, within Rv0633cat 730.172 kb on + strandat 730.173 kb on - strandat 730.173 kb on - strandat 730.173 kb on - strandat 730.174 kb on + strandat 730.201 kb on + strandat 730.372 kb on + strandat 730.372 kb on + strandat 730.373 kb on - strandat 730.484 kb on - strand, within Rv0634cat 730.539 kb on + strand, within Rv0634cat 730.539 kb on + strand, within Rv0634cat 730.540 kb on - strand, within Rv0634cat 730.737 kb on + strand, within Rv0634cat 730.738 kb on - strand, within Rv0634cat 730.848 kb on - strand, within Rv0634cat 730.889 kb on - strand, within Rv0634cat 730.889 kb on - strand, within Rv0634cat 731.014 kb on + strandat 731.015 kb on - strandat 731.015 kb on - strandat 731.044 kb on + strandat 731.044 kb on + strandat 731.045 kb on - strandat 731.101 kb on + strandat 731.101 kb on + strandat 731.102 kb on - strandat 731.102 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ciprofloxacin Hydrochloride 0.001 mM
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728,360 - -0.6
728,360 - -2.5
728,360 - -0.5
728,540 + -0.4
728,585 - +2.4
728,908 + Rv0632c 0.47 -1.5
728,909 - Rv0632c 0.47 -1.2
729,020 - Rv0632c 0.63 +1.0
729,257 + +2.6
729,260 - -0.3
729,260 - +0.0
729,328 + +0.7
729,508 + Rv0633c 0.22 -0.4
729,508 + Rv0633c 0.22 -0.2
729,521 + Rv0633c 0.23 -0.9
729,522 - Rv0633c 0.23 +0.1
729,522 - Rv0633c 0.23 -0.3
729,522 - Rv0633c 0.23 -0.7
729,525 + Rv0633c 0.24 +0.1
729,526 - Rv0633c 0.24 -0.5
729,691 + Rv0633c 0.43 -2.0
729,692 - Rv0633c 0.43 -0.5
729,694 + Rv0633c 0.44 -0.6
729,695 - Rv0633c 0.44 -0.2
729,838 + Rv0633c 0.61 -0.7
729,905 - Rv0633c 0.69 -0.9
729,934 - Rv0633c 0.72 -0.4
729,989 - Rv0633c 0.79 +0.1
729,989 - Rv0633c 0.79 -0.2
730,172 + -0.3
730,173 - -2.2
730,173 - -0.1
730,173 - +0.4
730,174 + -0.1
730,201 + +2.1
730,372 + +0.9
730,372 + -0.1
730,373 - -0.4
730,484 - Rv0634c 0.23 -0.5
730,539 + Rv0634c 0.31 -0.3
730,539 + Rv0634c 0.31 -1.1
730,540 - Rv0634c 0.31 -0.8
730,737 + Rv0634c 0.58 -0.1
730,738 - Rv0634c 0.59 -0.5
730,848 - Rv0634c 0.74 -2.7
730,889 - Rv0634c 0.80 -0.5
730,889 - Rv0634c 0.80 +0.5
731,014 + +0.0
731,015 - -1.1
731,015 - -0.2
731,044 + -0.2
731,044 + -0.1
731,045 - +0.3
731,101 + +0.2
731,101 + -0.3
731,102 - -1.3
731,102 - -0.6

Or see this region's nucleotide sequence