Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0214

Experiment: 7H9 with Ciprofloxacin Hydrochloride 0.001 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0213c and Rv0214 are separated by 113 nucleotidesRv0214 and Rv0215c are separated by 105 nucleotides Rv0213c: Rv0213c - Possible methyltransferase (methylase), at 254,637 to 255,950 Rv0213c Rv0214: Rv0214 - Probable fatty-acid-CoA ligase FadD4 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase), at 256,064 to 257,677 Rv0214 Rv0215c: Rv0215c - Probable acyl-CoA dehydrogenase FadE3, at 257,783 to 258,856 Rv0215c Position (kb) 256 257 258Strain fitness (log2 ratio) -2 -1 0 1at 255.089 kb on - strand, within Rv0213cat 255.272 kb on + strand, within Rv0213cat 255.273 kb on - strand, within Rv0213cat 255.295 kb on - strand, within Rv0213cat 255.311 kb on - strand, within Rv0213cat 255.381 kb on + strand, within Rv0213cat 255.381 kb on + strand, within Rv0213cat 255.429 kb on - strand, within Rv0213cat 255.573 kb on + strand, within Rv0213cat 255.573 kb on + strand, within Rv0213cat 255.697 kb on + strand, within Rv0213cat 255.697 kb on + strand, within Rv0213cat 255.697 kb on + strand, within Rv0213cat 255.831 kb on + strandat 255.982 kb on + strandat 255.982 kb on + strandat 256.018 kb on + strandat 256.019 kb on - strandat 256.019 kb on - strandat 256.082 kb on + strandat 256.176 kb on - strandat 256.176 kb on - strandat 256.209 kb on - strandat 256.209 kb on - strandat 256.376 kb on + strand, within Rv0214at 256.377 kb on - strand, within Rv0214at 256.380 kb on - strand, within Rv0214at 256.421 kb on + strand, within Rv0214at 256.421 kb on + strand, within Rv0214at 256.422 kb on - strand, within Rv0214at 256.635 kb on - strand, within Rv0214at 256.755 kb on + strand, within Rv0214at 256.756 kb on - strand, within Rv0214at 256.757 kb on + strand, within Rv0214at 256.758 kb on - strand, within Rv0214at 256.779 kb on - strand, within Rv0214at 257.069 kb on + strand, within Rv0214at 257.220 kb on - strand, within Rv0214at 257.247 kb on - strand, within Rv0214at 257.559 kb on + strandat 257.643 kb on - strandat 257.720 kb on + strandat 257.721 kb on - strandat 257.753 kb on - strandat 257.803 kb on - strandat 257.926 kb on - strand, within Rv0215cat 257.991 kb on + strand, within Rv0215cat 257.992 kb on - strand, within Rv0215cat 258.531 kb on + strand, within Rv0215cat 258.532 kb on - strand, within Rv0215cat 258.532 kb on - strand, within Rv0215cat 258.532 kb on - strand, within Rv0215cat 258.651 kb on + strand, within Rv0215c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ciprofloxacin Hydrochloride 0.001 mM
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255,089 - Rv0213c 0.34 -0.0
255,272 + Rv0213c 0.48 -2.0
255,273 - Rv0213c 0.48 -0.4
255,295 - Rv0213c 0.50 -0.6
255,311 - Rv0213c 0.51 +0.8
255,381 + Rv0213c 0.57 -0.0
255,381 + Rv0213c 0.57 -2.0
255,429 - Rv0213c 0.60 -1.3
255,573 + Rv0213c 0.71 -0.6
255,573 + Rv0213c 0.71 -0.7
255,697 + Rv0213c 0.81 -0.5
255,697 + Rv0213c 0.81 -0.1
255,697 + Rv0213c 0.81 -0.8
255,831 + -0.6
255,982 + -1.0
255,982 + -0.7
256,018 + -0.5
256,019 - -1.1
256,019 - -0.1
256,082 + +1.5
256,176 - -0.5
256,176 - -0.6
256,209 - +0.2
256,209 - +1.1
256,376 + Rv0214 0.19 -2.5
256,377 - Rv0214 0.19 +0.9
256,380 - Rv0214 0.20 -0.7
256,421 + Rv0214 0.22 -0.4
256,421 + Rv0214 0.22 +1.5
256,422 - Rv0214 0.22 +1.5
256,635 - Rv0214 0.35 -0.7
256,755 + Rv0214 0.43 -0.9
256,756 - Rv0214 0.43 -0.4
256,757 + Rv0214 0.43 +0.0
256,758 - Rv0214 0.43 +0.9
256,779 - Rv0214 0.44 -0.8
257,069 + Rv0214 0.62 -1.4
257,220 - Rv0214 0.72 -0.4
257,247 - Rv0214 0.73 -0.8
257,559 + -0.6
257,643 - -0.7
257,720 + -0.4
257,721 - -0.4
257,753 - -1.1
257,803 - -0.5
257,926 - Rv0215c 0.13 -0.5
257,991 + Rv0215c 0.19 -0.3
257,992 - Rv0215c 0.19 -0.7
258,531 + Rv0215c 0.70 -1.0
258,532 - Rv0215c 0.70 +0.9
258,532 - Rv0215c 0.70 +1.2
258,532 - Rv0215c 0.70 +0.3
258,651 + Rv0215c 0.81 -0.4

Or see this region's nucleotide sequence