Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2016

Experiment: 7H9 with Zinc Pyrithione 0.00072 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2015c and Rv2016 are separated by 353 nucleotidesRv2016 and Rv2017 overlap by 4 nucleotides Rv2015c: Rv2015c - Conserved hypothetical protein, at 2,261,816 to 2,263,072 Rv2015c Rv2016: Rv2016 - Hypothetical protein, at 2,263,426 to 2,264,001 Rv2016 Rv2017: Rv2017 - Transcriptional regulatory protein, at 2,263,998 to 2,265,038 Rv2017 Position (kb) 2263 2264 2265Strain fitness (log2 ratio) -1 0 1at 2263.293 kb on + strandat 2263.293 kb on + strandat 2263.293 kb on + strandat 2263.293 kb on + strandat 2263.293 kb on + strandat 2263.293 kb on + strandat 2263.294 kb on - strandat 2263.294 kb on - strandat 2263.294 kb on - strandat 2263.294 kb on - strandat 2263.294 kb on - strandat 2263.297 kb on + strandat 2263.298 kb on - strandat 2263.479 kb on + strandat 2263.714 kb on + strand, within Rv2016at 2263.714 kb on + strand, within Rv2016at 2263.715 kb on - strand, within Rv2016at 2263.819 kb on - strand, within Rv2016at 2263.881 kb on - strand, within Rv2016at 2263.944 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Zinc Pyrithione 0.00072 mM
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2,263,293 + -1.2
2,263,293 + -0.4
2,263,293 + -0.6
2,263,293 + -0.7
2,263,293 + -0.1
2,263,293 + -1.6
2,263,294 - -0.5
2,263,294 - -0.2
2,263,294 - +0.1
2,263,294 - +0.6
2,263,294 - +0.4
2,263,297 + -0.7
2,263,298 - +0.4
2,263,479 + +0.1
2,263,714 + Rv2016 0.50 -0.7
2,263,714 + Rv2016 0.50 -1.0
2,263,715 - Rv2016 0.50 -0.4
2,263,819 - Rv2016 0.68 -0.2
2,263,881 - Rv2016 0.79 -1.3
2,263,944 - +1.2

Or see this region's nucleotide sequence