Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1186c

Experiment: 7H9 with Zinc Pyrithione 0.00072 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1185c and Rv1186c are separated by 176 nucleotidesRv1186c and Rv1187 are separated by 84 nucleotides Rv1185c: Rv1185c - Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase), at 1,325,776 to 1,327,512 Rv1185c Rv1186c: Rv1186c - Conserved protein, at 1,327,689 to 1,329,305 Rv1186c Rv1187: Rv1187 - Probable pyrroline-5-carboxylate dehydrogenase RocA, at 1,329,390 to 1,331,021 Rv1187 Position (kb) 1327 1328 1329 1330Strain fitness (log2 ratio) -1 0 1 2at 1326.752 kb on - strand, within Rv1185cat 1326.752 kb on - strand, within Rv1185cat 1326.857 kb on + strand, within Rv1185cat 1326.882 kb on + strand, within Rv1185cat 1326.883 kb on - strand, within Rv1185cat 1326.883 kb on - strand, within Rv1185cat 1326.883 kb on - strand, within Rv1185cat 1327.007 kb on + strand, within Rv1185cat 1327.007 kb on + strand, within Rv1185cat 1327.007 kb on + strand, within Rv1185cat 1327.008 kb on - strand, within Rv1185cat 1327.100 kb on - strand, within Rv1185cat 1327.290 kb on - strand, within Rv1185cat 1327.290 kb on - strand, within Rv1185cat 1327.430 kb on + strandat 1327.431 kb on - strandat 1327.691 kb on - strandat 1327.786 kb on - strandat 1328.113 kb on - strand, within Rv1186cat 1328.118 kb on + strand, within Rv1186cat 1328.119 kb on - strand, within Rv1186cat 1328.430 kb on + strand, within Rv1186cat 1328.719 kb on - strand, within Rv1186cat 1328.804 kb on - strand, within Rv1186cat 1328.956 kb on + strand, within Rv1186cat 1329.321 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Zinc Pyrithione 0.00072 mM
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1,326,752 - Rv1185c 0.56 -0.3
1,326,752 - Rv1185c 0.56 +0.0
1,326,857 + Rv1185c 0.62 +0.6
1,326,882 + Rv1185c 0.64 -0.6
1,326,883 - Rv1185c 0.64 -0.2
1,326,883 - Rv1185c 0.64 -0.7
1,326,883 - Rv1185c 0.64 +0.4
1,327,007 + Rv1185c 0.71 +0.8
1,327,007 + Rv1185c 0.71 -0.1
1,327,007 + Rv1185c 0.71 -0.1
1,327,008 - Rv1185c 0.71 -0.5
1,327,100 - Rv1185c 0.76 -0.1
1,327,290 - Rv1185c 0.87 +1.8
1,327,290 - Rv1185c 0.87 +0.2
1,327,430 + -0.0
1,327,431 - -0.1
1,327,691 - -0.7
1,327,786 - +0.2
1,328,113 - Rv1186c 0.26 +1.3
1,328,118 + Rv1186c 0.27 -0.4
1,328,119 - Rv1186c 0.27 +1.8
1,328,430 + Rv1186c 0.46 +0.5
1,328,719 - Rv1186c 0.64 -0.6
1,328,804 - Rv1186c 0.69 +0.6
1,328,956 + Rv1186c 0.78 +1.8
1,329,321 + +1.8

Or see this region's nucleotide sequence