Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2802c

Experiment: 7H9 with Levofloxacin 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2800 and Rv2801c are separated by 101 nucleotidesRv2801c and Rv2801A overlap by 17 nucleotidesRv2801A and Rv2802c are separated by 42 nucleotidesRv2802c and Rv2803 overlap by 2 nucleotidesRv2803 and Rv2804c are separated by 175 nucleotides Rv2800: Rv2800 - Possible hydrolase, at 3,108,416 to 3,110,065 Rv2800 Rv2801c: Rv2801c - Toxin MazF9, at 3,110,167 to 3,110,523 Rv2801c Rv2801A: Rv2801A - Possible antitoxin MazE9, at 3,110,507 to 3,110,737 Rv2801A Rv2802c: Rv2802c - Hypothetical arginine and alanine rich protein, at 3,110,780 to 3,111,823 Rv2802c Rv2803: Rv2803 - Conserved hypothetical protein, at 3,111,822 to 3,112,289 Rv2803 Rv2804c: Rv2804c - Hypothetical protein, at 3,112,465 to 3,113,094 Rv2804c Position (kb) 3110 3111 3112Strain fitness (log2 ratio) -2 -1 0 1 2at 3109.956 kb on - strandat 3110.168 kb on + strandat 3110.168 kb on + strandat 3110.168 kb on + strandat 3110.169 kb on - strandat 3110.169 kb on - strandat 3110.176 kb on + strandat 3110.176 kb on + strandat 3110.177 kb on - strandat 3110.177 kb on - strandat 3110.177 kb on - strandat 3110.317 kb on - strand, within Rv2801cat 3110.472 kb on + strand, within Rv2801cat 3110.598 kb on + strand, within Rv2801Aat 3110.599 kb on - strand, within Rv2801Aat 3110.620 kb on - strand, within Rv2801Aat 3110.685 kb on + strand, within Rv2801Aat 3110.685 kb on + strand, within Rv2801Aat 3110.962 kb on + strand, within Rv2802cat 3111.207 kb on + strand, within Rv2802cat 3111.207 kb on + strand, within Rv2802cat 3111.214 kb on + strand, within Rv2802cat 3111.567 kb on + strand, within Rv2802cat 3111.656 kb on + strand, within Rv2802cat 3111.656 kb on + strand, within Rv2802cat 3111.656 kb on + strand, within Rv2802cat 3111.656 kb on + strand, within Rv2802cat 3111.657 kb on - strand, within Rv2802cat 3111.873 kb on + strand, within Rv2803at 3111.874 kb on - strand, within Rv2803at 3111.996 kb on + strand, within Rv2803at 3111.996 kb on + strand, within Rv2803at 3111.997 kb on - strand, within Rv2803at 3111.997 kb on - strand, within Rv2803at 3111.997 kb on - strand, within Rv2803at 3111.997 kb on - strand, within Rv2803at 3112.002 kb on + strand, within Rv2803at 3112.002 kb on + strand, within Rv2803at 3112.007 kb on + strand, within Rv2803at 3112.007 kb on + strand, within Rv2803at 3112.007 kb on + strand, within Rv2803at 3112.008 kb on - strand, within Rv2803at 3112.008 kb on - strand, within Rv2803at 3112.008 kb on - strand, within Rv2803at 3112.008 kb on - strand, within Rv2803at 3112.008 kb on - strand, within Rv2803at 3112.011 kb on + strand, within Rv2803at 3112.011 kb on + strand, within Rv2803at 3112.012 kb on - strand, within Rv2803at 3112.012 kb on - strand, within Rv2803at 3112.466 kb on + strandat 3112.658 kb on - strand, within Rv2804cat 3112.658 kb on - strand, within Rv2804cat 3112.712 kb on - strand, within Rv2804cat 3112.712 kb on - strand, within Rv2804cat 3112.791 kb on - strand, within Rv2804cat 3112.791 kb on - strand, within Rv2804c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Levofloxacin 0.3 ug/mL
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3,109,956 - +0.8
3,110,168 + -0.4
3,110,168 + -0.8
3,110,168 + +0.2
3,110,169 - -1.2
3,110,169 - -0.6
3,110,176 + +0.5
3,110,176 + -0.5
3,110,177 - +2.6
3,110,177 - -1.2
3,110,177 - -0.0
3,110,317 - Rv2801c 0.42 -0.5
3,110,472 + Rv2801c 0.85 +0.1
3,110,598 + Rv2801A 0.39 -0.2
3,110,599 - Rv2801A 0.40 +0.4
3,110,620 - Rv2801A 0.49 +0.1
3,110,685 + Rv2801A 0.77 +0.3
3,110,685 + Rv2801A 0.77 +0.9
3,110,962 + Rv2802c 0.17 +0.6
3,111,207 + Rv2802c 0.41 -0.5
3,111,207 + Rv2802c 0.41 -2.3
3,111,214 + Rv2802c 0.42 +0.1
3,111,567 + Rv2802c 0.75 -0.1
3,111,656 + Rv2802c 0.84 -1.0
3,111,656 + Rv2802c 0.84 -1.3
3,111,656 + Rv2802c 0.84 -1.3
3,111,656 + Rv2802c 0.84 -0.9
3,111,657 - Rv2802c 0.84 +0.5
3,111,873 + Rv2803 0.11 -0.4
3,111,874 - Rv2803 0.11 -0.0
3,111,996 + Rv2803 0.37 -0.3
3,111,996 + Rv2803 0.37 +0.6
3,111,997 - Rv2803 0.37 +0.3
3,111,997 - Rv2803 0.37 -0.3
3,111,997 - Rv2803 0.37 -0.5
3,111,997 - Rv2803 0.37 -0.0
3,112,002 + Rv2803 0.38 +1.7
3,112,002 + Rv2803 0.38 -0.8
3,112,007 + Rv2803 0.40 +0.4
3,112,007 + Rv2803 0.40 +1.6
3,112,007 + Rv2803 0.40 -0.3
3,112,008 - Rv2803 0.40 +0.1
3,112,008 - Rv2803 0.40 -0.1
3,112,008 - Rv2803 0.40 -0.0
3,112,008 - Rv2803 0.40 +0.4
3,112,008 - Rv2803 0.40 -0.4
3,112,011 + Rv2803 0.40 -0.2
3,112,011 + Rv2803 0.40 -0.3
3,112,012 - Rv2803 0.41 +0.3
3,112,012 - Rv2803 0.41 -1.5
3,112,466 + -0.7
3,112,658 - Rv2804c 0.31 -1.0
3,112,658 - Rv2804c 0.31 -1.2
3,112,712 - Rv2804c 0.39 -0.2
3,112,712 - Rv2804c 0.39 -0.1
3,112,791 - Rv2804c 0.52 -0.4
3,112,791 - Rv2804c 0.52 -0.4

Or see this region's nucleotide sequence