Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2879c

Experiment: 7H9 with Linezolid 0.3 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2877c and Rv2878c are separated by 4 nucleotidesRv2878c and Rv2879c are separated by 185 nucleotidesRv2879c and Rv2880c overlap by 302 nucleotidesRv2880c and Rv2881c are separated by 22 nucleotides Rv2877c: Rv2877c - Probable conserved integral membrane protein, at 3,188,008 to 3,188,871 Rv2877c Rv2878c: Rv2878c - Soluble secreted antigen Mpt53 precursor, at 3,188,876 to 3,189,397 Rv2878c Rv2879c: Rv2879c - Conserved hypothetical protein, at 3,189,583 to 3,190,152 Rv2879c Rv2880c: Rv2880c - Conserved hypothetical protein, at 3,189,851 to 3,190,678 Rv2880c Rv2881c: Rv2881c - Probable integral membrane phosphatidate cytidylyltransferase CdsA (CDP-diglyceride synthetase) (CDP-diglyceride pyrophosphorylase) (CDP-diacylglycerol synthase) (CDS) (CTP:phosphatidate cytidylyltransferase) (CDP-DAG synthase) (CDP-DG synthetase), at 3,190,701 to 3,191,621 Rv2881c Position (kb) 3189 3190 3191Strain fitness (log2 ratio) -2 -1 0 1 2 3 4at 3188.612 kb on + strand, within Rv2877cat 3188.612 kb on + strand, within Rv2877cat 3188.612 kb on + strand, within Rv2877cat 3188.621 kb on + strand, within Rv2877cat 3188.621 kb on + strand, within Rv2877cat 3188.622 kb on - strand, within Rv2877cat 3188.768 kb on + strand, within Rv2877cat 3188.769 kb on - strand, within Rv2877cat 3188.769 kb on - strand, within Rv2877cat 3188.769 kb on - strand, within Rv2877cat 3188.970 kb on + strand, within Rv2878cat 3188.970 kb on + strand, within Rv2878cat 3189.003 kb on + strand, within Rv2878cat 3189.003 kb on + strand, within Rv2878cat 3189.305 kb on - strand, within Rv2878cat 3189.338 kb on - strand, within Rv2878cat 3189.428 kb on - strandat 3189.458 kb on + strandat 3189.459 kb on - strandat 3189.580 kb on + strandat 3189.646 kb on + strand, within Rv2879cat 3189.848 kb on + strand, within Rv2879cat 3189.856 kb on - strandat 3189.940 kb on + strandat 3189.940 kb on + strandat 3189.940 kb on + strandat 3189.941 kb on - strandat 3189.941 kb on - strandat 3189.941 kb on - strandat 3190.130 kb on + strandat 3190.130 kb on + strandat 3190.130 kb on + strandat 3190.131 kb on - strandat 3190.372 kb on + strand, within Rv2880cat 3190.373 kb on - strand, within Rv2880cat 3190.442 kb on - strand, within Rv2880cat 3190.533 kb on + strand, within Rv2880cat 3190.533 kb on + strand, within Rv2880cat 3190.533 kb on + strand, within Rv2880cat 3190.534 kb on - strand, within Rv2880cat 3190.536 kb on + strand, within Rv2880cat 3190.536 kb on + strand, within Rv2880cat 3190.537 kb on - strand, within Rv2880cat 3190.537 kb on - strand, within Rv2880cat 3190.537 kb on - strand, within Rv2880c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Linezolid 0.3 ug/mL
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3,188,612 + Rv2877c 0.70 -1.1
3,188,612 + Rv2877c 0.70 -0.1
3,188,612 + Rv2877c 0.70 -0.3
3,188,621 + Rv2877c 0.71 -0.4
3,188,621 + Rv2877c 0.71 +0.2
3,188,622 - Rv2877c 0.71 -0.2
3,188,768 + Rv2877c 0.88 +4.2
3,188,769 - Rv2877c 0.88 -0.2
3,188,769 - Rv2877c 0.88 -0.1
3,188,769 - Rv2877c 0.88 +0.8
3,188,970 + Rv2878c 0.18 +0.5
3,188,970 + Rv2878c 0.18 +0.3
3,189,003 + Rv2878c 0.24 +0.1
3,189,003 + Rv2878c 0.24 -0.6
3,189,305 - Rv2878c 0.82 -1.1
3,189,338 - Rv2878c 0.89 -0.4
3,189,428 - -0.8
3,189,458 + +0.2
3,189,459 - -0.4
3,189,580 + -0.3
3,189,646 + Rv2879c 0.11 +0.7
3,189,848 + Rv2879c 0.46 +1.6
3,189,856 - -0.3
3,189,940 + -1.2
3,189,940 + -0.4
3,189,940 + -0.2
3,189,941 - +1.6
3,189,941 - -0.1
3,189,941 - +0.1
3,190,130 + -1.1
3,190,130 + -0.5
3,190,130 + -0.6
3,190,131 - +0.7
3,190,372 + Rv2880c 0.63 -0.3
3,190,373 - Rv2880c 0.63 +0.0
3,190,442 - Rv2880c 0.71 -0.4
3,190,533 + Rv2880c 0.82 -2.5
3,190,533 + Rv2880c 0.82 -0.5
3,190,533 + Rv2880c 0.82 +0.6
3,190,534 - Rv2880c 0.82 -1.7
3,190,536 + Rv2880c 0.83 -1.4
3,190,536 + Rv2880c 0.83 +0.3
3,190,537 - Rv2880c 0.83 -0.4
3,190,537 - Rv2880c 0.83 -0.8
3,190,537 - Rv2880c 0.83 -0.7

Or see this region's nucleotide sequence