Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2761c

Experiment: 7H9 with Linezolid 0.3 ug/mL

Add experiment(s):

Zoom: Pan:

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

download SVG
500 ntRv2757c and Rv2758c overlap by 4 nucleotidesRv2758c and Rv2759c are separated by 25 nucleotidesRv2759c and Rv2760c overlap by 4 nucleotidesRv2760c and Rv2761c are separated by 9 nucleotidesRv2761c and Rv2762c overlap by 4 nucleotidesRv2762c and Rv2763c are separated by 73 nucleotides Rv2757c: Rv2757c - Possible toxin VapC21, at 3,070,170 to 3,070,586 Rv2757c Rv2758c: Rv2758c - Possible antitoxin VapB21, at 3,070,583 to 3,070,849 Rv2758c Rv2759c: Rv2759c - Possible toxin VapC42. Contains PIN domain., at 3,070,875 to 3,071,270 Rv2759c Rv2760c: Rv2760c - Possible antitoxin VapB42, at 3,071,267 to 3,071,536 Rv2760c Rv2761c: Rv2761c - Possible type I restriction/modification system specificity determinant HsdS (S protein), at 3,071,546 to 3,072,640 Rv2761c Rv2762c: Rv2762c - Conserved hypothetical protein, at 3,072,637 to 3,073,056 Rv2762c Rv2763c: Rv2763c - Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase), at 3,073,130 to 3,073,609 Rv2763c Position (kb) 3071 3072 3073Strain fitness (log2 ratio) -2 -1 0 1at 3070.747 kb on + strand, within Rv2758cat 3070.826 kb on + strandat 3070.901 kb on + strandat 3070.961 kb on - strand, within Rv2759cat 3070.966 kb on + strand, within Rv2759cat 3070.966 kb on + strand, within Rv2759cat 3070.966 kb on + strand, within Rv2759cat 3070.966 kb on + strand, within Rv2759cat 3070.966 kb on + strand, within Rv2759cat 3070.967 kb on - strand, within Rv2759cat 3070.967 kb on - strand, within Rv2759cat 3071.015 kb on - strand, within Rv2759cat 3071.158 kb on + strand, within Rv2759cat 3071.159 kb on - strand, within Rv2759cat 3071.159 kb on - strand, within Rv2759cat 3071.292 kb on + strandat 3071.293 kb on - strandat 3071.525 kb on - strandat 3071.525 kb on - strandat 3071.525 kb on - strandat 3071.525 kb on - strandat 3072.039 kb on + strand, within Rv2761cat 3072.040 kb on - strand, within Rv2761cat 3072.117 kb on + strand, within Rv2761cat 3072.118 kb on - strand, within Rv2761cat 3072.118 kb on - strand, within Rv2761cat 3072.118 kb on - strand, within Rv2761cat 3072.345 kb on + strand, within Rv2761cat 3072.346 kb on - strand, within Rv2761cat 3072.441 kb on + strand, within Rv2761cat 3072.523 kb on - strand, within Rv2761cat 3072.574 kb on + strandat 3072.605 kb on + strandat 3072.611 kb on + strandat 3072.778 kb on + strand, within Rv2762c

download strain data

Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Linezolid 0.3 ug/mL
remove
3,070,747 + Rv2758c 0.61 +1.4
3,070,826 + -1.1
3,070,901 + -0.5
3,070,961 - Rv2759c 0.22 +0.2
3,070,966 + Rv2759c 0.23 +0.0
3,070,966 + Rv2759c 0.23 +0.2
3,070,966 + Rv2759c 0.23 +0.1
3,070,966 + Rv2759c 0.23 -0.8
3,070,966 + Rv2759c 0.23 -0.1
3,070,967 - Rv2759c 0.23 -0.3
3,070,967 - Rv2759c 0.23 -0.0
3,071,015 - Rv2759c 0.35 -0.5
3,071,158 + Rv2759c 0.71 -0.3
3,071,159 - Rv2759c 0.72 -0.8
3,071,159 - Rv2759c 0.72 -0.2
3,071,292 + +0.2
3,071,293 - -0.2
3,071,525 - -0.5
3,071,525 - -0.3
3,071,525 - +0.8
3,071,525 - +0.4
3,072,039 + Rv2761c 0.45 -0.4
3,072,040 - Rv2761c 0.45 -0.1
3,072,117 + Rv2761c 0.52 +1.6
3,072,118 - Rv2761c 0.52 -0.6
3,072,118 - Rv2761c 0.52 -1.6
3,072,118 - Rv2761c 0.52 -0.6
3,072,345 + Rv2761c 0.73 -0.3
3,072,346 - Rv2761c 0.73 -2.1
3,072,441 + Rv2761c 0.82 -1.5
3,072,523 - Rv2761c 0.89 -0.1
3,072,574 + +0.0
3,072,605 + -0.4
3,072,611 + +0.5
3,072,778 + Rv2762c 0.34 -0.1

Or see this region's nucleotide sequence