Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0101

Experiment: 7H9 with Linezolid 0.3 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Linezolid 0.3 ug/mL
109,286	-		Rv0099	0.70	+0.8
109,286	-		Rv0099	0.70	+0.9
109,822	+		Rv0100	0.16	-0.1
109,916	+		Rv0100	0.56	-1.2
109,917	-		Rv0100	0.57	+0.9
110,041	-				+0.4
110,075	-				-1.0
110,075	-				-0.2
110,149	+				-0.3
111,148	+		Rv0101	0.15	-0.4
111,148	+		Rv0101	0.15	+1.3
111,148	+		Rv0101	0.15	+1.1
111,726	+		Rv0101	0.23	-0.7
111,750	-		Rv0101	0.23	-0.2
112,514	-		Rv0101	0.33	-0.6
112,923	-		Rv0101	0.39	+1.0
112,926	+		Rv0101	0.39	-0.2
112,927	-		Rv0101	0.39	-0.3
113,113	+		Rv0101	0.41	-0.5
113,114	-		Rv0101	0.41	-0.1
113,114	-		Rv0101	0.41	+0.7
113,396	-		Rv0101	0.45	+1.7
113,518	-		Rv0101	0.47	-0.5
113,571	+		Rv0101	0.47	-0.7
113,571	+		Rv0101	0.47	-0.6
113,572	-		Rv0101	0.47	+0.0
113,580	+		Rv0101	0.47	-0.2
113,581	-		Rv0101	0.47	-0.2
113,713	-		Rv0101	0.49	+0.7
113,828	-		Rv0101	0.51	+1.1
114,034	-		Rv0101	0.53	+0.1
114,049	+		Rv0101	0.54	+0.3
114,706	-		Rv0101	0.62	-0.1
114,706	-		Rv0101	0.62	-0.3
114,850	+		Rv0101	0.64	+0.4
114,859	-		Rv0101	0.64	+0.1
114,912	+		Rv0101	0.65	+0.2
114,913	-		Rv0101	0.65	-0.1
115,035	+		Rv0101	0.67	-0.3
115,035	+		Rv0101	0.67	+2.7
115,036	-		Rv0101	0.67	+0.1
115,078	+		Rv0101	0.67	-0.2
115,079	-		Rv0101	0.67	+0.1
115,079	-		Rv0101	0.67	-0.3
115,079	-		Rv0101	0.67	-0.2
115,079	-		Rv0101	0.67	+2.3
115,305	+		Rv0101	0.70	-0.6
115,340	-		Rv0101	0.71	+0.1
115,418	+		Rv0101	0.72	-1.1
115,419	-		Rv0101	0.72	-0.7
115,461	+		Rv0101	0.72	+0.6
115,462	-		Rv0101	0.72	-2.2
115,462	-		Rv0101	0.72	+1.1
115,563	+		Rv0101	0.74	+1.7
115,717	+		Rv0101	0.76	-1.9
115,858	+		Rv0101	0.78	+0.7
116,098	+		Rv0101	0.81	+0.3
116,153	-		Rv0101	0.82	-0.3
116,364	+		Rv0101	0.84	-0.4
116,365	-		Rv0101	0.84	-0.4
116,733	+		Rv0101	0.89	+0.0
116,734	-		Rv0101	0.89	-2.2
116,734	-		Rv0101	0.89	-0.3
117,039	+				+1.1
117,039	+				+2.4
117,169	-				-0.0
117,214	-				+0.1
117,214	-				-2.0
117,214	-				-0.1
117,517	+				-1.5
117,517	+				-0.7
117,518	-				-0.1
117,622	+				+2.0
117,622	+				+0.6
117,623	-				+0.2
117,641	-				+0.0
117,787	+				-0.2