Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2468A

Experiment: 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2467 and Rv2468c are separated by 72 nucleotidesRv2468c and Rv2468A overlap by 50 nucleotidesRv2468A and Rv2469c are separated by 35 nucleotidesRv2469c and Rv2470 are separated by 142 nucleotides Rv2467: Rv2467 - Probable aminopeptidase N PepN (Lysyl aminopeptidase) (LYS-AP) (alanine aminopeptidase), at 2,768,986 to 2,771,571 Rv2467 Rv2468c: Rv2468c - Conserved protein, at 2,771,644 to 2,772,147 Rv2468c Rv2468A: Rv2468A - Conserved protein, at 2,772,098 to 2,772,331 Rv2468A Rv2469c: Rv2469c - Conserved hypothetical protein, at 2,772,367 to 2,773,035 Rv2469c Rv2470: Rv2470 - Globin (oxygen-binding protein) GlbO, at 2,773,178 to 2,773,564 Rv2470 Position (kb) 2772 2773Strain fitness (log2 ratio) -1 0 1 2at 2771.344 kb on + strandat 2771.366 kb on + strandat 2771.417 kb on - strandat 2771.621 kb on + strandat 2771.698 kb on + strand, within Rv2468cat 2771.699 kb on - strand, within Rv2468cat 2771.789 kb on + strand, within Rv2468cat 2771.789 kb on + strand, within Rv2468cat 2771.948 kb on + strand, within Rv2468cat 2771.948 kb on + strand, within Rv2468cat 2771.949 kb on - strand, within Rv2468cat 2772.235 kb on - strand, within Rv2468Aat 2772.235 kb on - strand, within Rv2468Aat 2772.235 kb on - strand, within Rv2468Aat 2772.235 kb on - strand, within Rv2468Aat 2772.331 kb on + strandat 2772.332 kb on - strandat 2772.353 kb on - strandat 2772.389 kb on + strandat 2772.389 kb on + strandat 2772.618 kb on - strand, within Rv2469cat 2772.695 kb on + strand, within Rv2469cat 2772.695 kb on + strand, within Rv2469cat 2772.695 kb on + strand, within Rv2469cat 2772.695 kb on + strand, within Rv2469cat 2772.695 kb on + strand, within Rv2469cat 2772.696 kb on - strand, within Rv2469cat 2772.696 kb on - strand, within Rv2469cat 2772.845 kb on + strand, within Rv2469cat 2772.846 kb on - strand, within Rv2469cat 2772.846 kb on - strand, within Rv2469cat 2772.846 kb on - strand, within Rv2469cat 2772.979 kb on + strandat 2772.980 kb on - strandat 2773.035 kb on + strandat 2773.152 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM
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2,771,344 + -1.3
2,771,366 + -0.1
2,771,417 - -0.4
2,771,621 + -0.8
2,771,698 + Rv2468c 0.11 +0.5
2,771,699 - Rv2468c 0.11 -0.6
2,771,789 + Rv2468c 0.29 -0.8
2,771,789 + Rv2468c 0.29 -0.1
2,771,948 + Rv2468c 0.60 -0.2
2,771,948 + Rv2468c 0.60 +1.8
2,771,949 - Rv2468c 0.61 -0.5
2,772,235 - Rv2468A 0.59 -1.3
2,772,235 - Rv2468A 0.59 +0.1
2,772,235 - Rv2468A 0.59 -0.9
2,772,235 - Rv2468A 0.59 -1.2
2,772,331 + -0.2
2,772,332 - -0.5
2,772,353 - -0.9
2,772,389 + +0.3
2,772,389 + -0.1
2,772,618 - Rv2469c 0.38 -0.3
2,772,695 + Rv2469c 0.49 -0.4
2,772,695 + Rv2469c 0.49 +0.1
2,772,695 + Rv2469c 0.49 -0.3
2,772,695 + Rv2469c 0.49 -0.5
2,772,695 + Rv2469c 0.49 -0.0
2,772,696 - Rv2469c 0.49 +0.3
2,772,696 - Rv2469c 0.49 -0.2
2,772,845 + Rv2469c 0.71 -1.2
2,772,846 - Rv2469c 0.72 -0.2
2,772,846 - Rv2469c 0.72 -0.7
2,772,846 - Rv2469c 0.72 -0.4
2,772,979 + -1.2
2,772,980 - -0.4
2,773,035 + -0.9
2,773,152 - +0.1

Or see this region's nucleotide sequence