Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1974

Experiment: 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1972 and Rv1973 overlap by 4 nucleotidesRv1973 and Rv1974 are separated by 12 nucleotidesRv1974 and Rv1975 are separated by 15 nucleotidesRv1975 and Rv1976c are separated by 126 nucleotides Rv1972: Rv1972 - Probable conserved Mce associated membrane protein, at 2,216,592 to 2,217,167 Rv1972 Rv1973: Rv1973 - Possible conserved Mce associated membrane protein, at 2,217,164 to 2,217,646 Rv1973 Rv1974: Rv1974 - Probable conserved membrane protein, at 2,217,659 to 2,218,036 Rv1974 Rv1975: Rv1975 - Conserved hypothetical protein, at 2,218,052 to 2,218,717 Rv1975 Rv1976c: Rv1976c - Conserved hypothetical protein, at 2,218,844 to 2,219,251 Rv1976c Position (kb) 2217 2218 2219Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 2216.842 kb on + strand, within Rv1972at 2216.843 kb on - strand, within Rv1972at 2216.843 kb on - strand, within Rv1972at 2216.843 kb on - strand, within Rv1972at 2216.913 kb on + strand, within Rv1972at 2216.914 kb on - strand, within Rv1972at 2216.953 kb on + strand, within Rv1972at 2216.953 kb on + strand, within Rv1972at 2216.954 kb on - strand, within Rv1972at 2217.332 kb on + strand, within Rv1973at 2217.405 kb on - strand, within Rv1973at 2217.779 kb on + strand, within Rv1974at 2217.842 kb on + strand, within Rv1974at 2217.843 kb on - strand, within Rv1974at 2217.947 kb on + strand, within Rv1974at 2217.947 kb on + strand, within Rv1974at 2217.947 kb on + strand, within Rv1974at 2218.040 kb on - strandat 2218.172 kb on + strand, within Rv1975at 2218.228 kb on - strand, within Rv1975at 2218.404 kb on + strand, within Rv1975at 2218.405 kb on - strand, within Rv1975at 2218.415 kb on + strand, within Rv1975at 2218.415 kb on + strand, within Rv1975at 2218.415 kb on + strand, within Rv1975at 2218.418 kb on + strand, within Rv1975at 2218.418 kb on + strand, within Rv1975at 2218.418 kb on + strand, within Rv1975at 2218.419 kb on - strand, within Rv1975at 2218.564 kb on - strand, within Rv1975at 2218.606 kb on + strand, within Rv1975at 2218.625 kb on + strand, within Rv1975at 2218.779 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM
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2,216,842 + Rv1972 0.43 -2.1
2,216,843 - Rv1972 0.44 -0.9
2,216,843 - Rv1972 0.44 +0.4
2,216,843 - Rv1972 0.44 -0.3
2,216,913 + Rv1972 0.56 +0.1
2,216,914 - Rv1972 0.56 +0.6
2,216,953 + Rv1972 0.63 +2.1
2,216,953 + Rv1972 0.63 -0.1
2,216,954 - Rv1972 0.63 -1.7
2,217,332 + Rv1973 0.35 +0.1
2,217,405 - Rv1973 0.50 -0.4
2,217,779 + Rv1974 0.32 -3.2
2,217,842 + Rv1974 0.48 -0.7
2,217,843 - Rv1974 0.49 -0.2
2,217,947 + Rv1974 0.76 +0.2
2,217,947 + Rv1974 0.76 -2.2
2,217,947 + Rv1974 0.76 -1.9
2,218,040 - -0.2
2,218,172 + Rv1975 0.18 -1.4
2,218,228 - Rv1975 0.26 -0.7
2,218,404 + Rv1975 0.53 +0.1
2,218,405 - Rv1975 0.53 +0.0
2,218,415 + Rv1975 0.55 -0.9
2,218,415 + Rv1975 0.55 -0.5
2,218,415 + Rv1975 0.55 +0.9
2,218,418 + Rv1975 0.55 +0.6
2,218,418 + Rv1975 0.55 -0.5
2,218,418 + Rv1975 0.55 +0.6
2,218,419 - Rv1975 0.55 -0.3
2,218,564 - Rv1975 0.77 +0.3
2,218,606 + Rv1975 0.83 +0.2
2,218,625 + Rv1975 0.86 +0.1
2,218,779 - +0.4

Or see this region's nucleotide sequence