Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1513

Experiment: 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1511 and Rv1512 overlap by 4 nucleotidesRv1512 and Rv1513 overlap by 4 nucleotidesRv1513 and Rv1514c are separated by 17 nucleotidesRv1514c and Rv1515c are separated by 34 nucleotides Rv1511: Rv1511 - GDP-D-mannose dehydratase GmdA (GDP-mannose 4,6 dehydratase) (GMD), at 1,703,074 to 1,704,096 Rv1511 Rv1512: Rv1512 - Probable nucleotide-sugar epimerase EpiA, at 1,704,093 to 1,705,061 Rv1512 Rv1513: Rv1513 - Conserved protein, at 1,705,058 to 1,705,789 Rv1513 Rv1514c: Rv1514c - Conserved hypothetical protein, at 1,705,807 to 1,706,595 Rv1514c Rv1515c: Rv1515c - Conserved hypothetical protein, at 1,706,630 to 1,707,526 Rv1515c Position (kb) 1705 1706Strain fitness (log2 ratio) -1 0 1at 1704.453 kb on + strand, within Rv1512at 1705.454 kb on + strand, within Rv1513at 1705.525 kb on + strand, within Rv1513at 1705.854 kb on - strandat 1705.859 kb on + strandat 1705.876 kb on + strandat 1706.054 kb on - strand, within Rv1514cat 1706.442 kb on - strand, within Rv1514cat 1706.442 kb on - strand, within Rv1514cat 1706.476 kb on + strand, within Rv1514cat 1706.607 kb on - strandat 1706.677 kb on - strandat 1706.772 kb on - strand, within Rv1515c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM
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1,704,453 + Rv1512 0.37 +1.0
1,705,454 + Rv1513 0.54 -1.5
1,705,525 + Rv1513 0.64 -0.5
1,705,854 - +0.1
1,705,859 + +0.3
1,705,876 + +0.1
1,706,054 - Rv1514c 0.31 +0.8
1,706,442 - Rv1514c 0.80 -0.0
1,706,442 - Rv1514c 0.80 +0.2
1,706,476 + Rv1514c 0.85 +0.1
1,706,607 - -0.2
1,706,677 - -1.4
1,706,772 - Rv1515c 0.16 +0.2

Or see this region's nucleotide sequence