Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1188

Experiment: 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1187 and Rv1188 overlap by 1 nucleotidesRv1188 and Rv1189 are separated by 81 nucleotidesRv1189 and Rv1190 are separated by 15 nucleotides Rv1187: Rv1187 - Probable pyrroline-5-carboxylate dehydrogenase RocA, at 1,329,390 to 1,331,021 Rv1187 Rv1188: Rv1188 - Probable proline dehydrogenase, at 1,331,021 to 1,332,010 Rv1188 Rv1189: Rv1189 - Possible alternative RNA polymerase sigma factor SigI, at 1,332,092 to 1,332,964 Rv1189 Rv1190: Rv1190 - Conserved hypothetical protein, at 1,332,980 to 1,333,858 Rv1190 Position (kb) 1331 1332 1333Strain fitness (log2 ratio) -1 0 1at 1330.837 kb on - strand, within Rv1187at 1331.822 kb on + strand, within Rv1188at 1331.882 kb on + strand, within Rv1188at 1331.883 kb on - strand, within Rv1188at 1332.913 kb on - strandat 1332.913 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM
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1,330,837 - Rv1187 0.89 +0.0
1,331,822 + Rv1188 0.81 +0.6
1,331,882 + Rv1188 0.87 -1.0
1,331,883 - Rv1188 0.87 -0.8
1,332,913 - -0.2
1,332,913 - -0.4

Or see this region's nucleotide sequence