Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0240

Experiment: 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0237 and Rv0238 are separated by 75 nucleotidesRv0238 and Rv0239 are separated by 61 nucleotidesRv0239 and Rv0240 are separated by 7 nucleotidesRv0240 and Rv0241c are separated by 29 nucleotidesRv0241c and Rv0242c are separated by 10 nucleotides Rv0237: Rv0237 - Probable conserved lipoprotein LpqI, at 287,186 to 288,352 Rv0237 Rv0238: Rv0238 - Possible transcriptional regulatory protein (probably TetR-family), at 288,428 to 289,042 Rv0238 Rv0239: Rv0239 - Possible antitoxin VapB24, at 289,104 to 289,337 Rv0239 Rv0240: Rv0240 - Possible toxin VapC24. Contains PIN domain., at 289,345 to 289,782 Rv0240 Rv0241c: Rv0241c - Probable 3-hydroxyacyl-thioester dehydratase HtdX, at 289,812 to 290,654 Rv0241c Rv0242c: Rv0242c - Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase), at 290,665 to 292,029 Rv0242c Position (kb) 289 290Strain fitness (log2 ratio) -2 -1 0 1 2at 288.385 kb on - strandat 288.390 kb on + strandat 288.394 kb on + strandat 288.394 kb on + strandat 289.075 kb on + strandat 289.227 kb on + strand, within Rv0239at 289.365 kb on + strandat 289.376 kb on - strandat 289.473 kb on + strand, within Rv0240at 289.474 kb on - strand, within Rv0240at 289.484 kb on - strand, within Rv0240at 289.503 kb on + strand, within Rv0240at 289.504 kb on - strand, within Rv0240at 289.636 kb on - strand, within Rv0240at 289.656 kb on - strand, within Rv0240at 289.814 kb on - strandat 289.860 kb on - strandat 289.904 kb on - strand, within Rv0241cat 289.904 kb on - strand, within Rv0241cat 289.985 kb on + strand, within Rv0241cat 290.389 kb on - strand, within Rv0241c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM
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288,385 - -0.1
288,390 + +2.3
288,394 + +0.0
288,394 + -0.5
289,075 + -0.6
289,227 + Rv0239 0.53 -0.3
289,365 + -0.2
289,376 - -0.1
289,473 + Rv0240 0.29 -1.3
289,474 - Rv0240 0.29 -0.3
289,484 - Rv0240 0.32 -0.1
289,503 + Rv0240 0.36 -2.0
289,504 - Rv0240 0.36 +0.8
289,636 - Rv0240 0.66 -0.8
289,656 - Rv0240 0.71 -0.8
289,814 - -0.9
289,860 - -0.6
289,904 - Rv0241c 0.11 -0.4
289,904 - Rv0241c 0.11 -2.7
289,985 + Rv0241c 0.21 +0.9
290,389 - Rv0241c 0.68 -0.8

Or see this region's nucleotide sequence