Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1215c

Experiment: 7H9 with Hydrogen peroxide 3.97 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1213 and Rv1214c are separated by 242 nucleotidesRv1214c and Rv1215c are separated by 133 nucleotidesRv1215c and Rv1216c are separated by 27 nucleotidesRv1216c and Rv1217c are separated by 8 nucleotides Rv1213: Rv1213 - Glucose-1-phosphate adenylyltransferase GlgC (ADP-glucose synthase) (ADP-glucose pyrophosphorylase), at 1,355,836 to 1,357,050 Rv1213 Rv1214c: Rv1214c - PE family protein PE14, at 1,357,293 to 1,357,625 Rv1214c Rv1215c: Rv1215c - Conserved protein, at 1,357,759 to 1,359,444 Rv1215c Rv1216c: Rv1216c - Probable conserved integral membrane protein, at 1,359,472 to 1,360,146 Rv1216c Rv1217c: Rv1217c - Probable tetronasin-transport integral membrane protein ABC transporter, at 1,360,155 to 1,361,801 Rv1217c Position (kb) 1357 1358 1359 1360Strain fitness (log2 ratio) -2 -1 0 1 2at 1357.049 kb on - strandat 1357.423 kb on - strand, within Rv1214cat 1357.423 kb on - strand, within Rv1214cat 1357.458 kb on - strand, within Rv1214cat 1357.469 kb on - strand, within Rv1214cat 1357.469 kb on - strand, within Rv1214cat 1357.645 kb on - strandat 1357.913 kb on - strandat 1358.105 kb on + strand, within Rv1215cat 1358.339 kb on + strand, within Rv1215cat 1358.507 kb on + strand, within Rv1215cat 1358.540 kb on + strand, within Rv1215cat 1358.540 kb on + strand, within Rv1215cat 1358.541 kb on - strand, within Rv1215cat 1358.723 kb on + strand, within Rv1215cat 1358.723 kb on + strand, within Rv1215cat 1358.724 kb on - strand, within Rv1215cat 1358.901 kb on - strand, within Rv1215cat 1358.901 kb on - strand, within Rv1215cat 1358.901 kb on - strand, within Rv1215cat 1359.147 kb on - strand, within Rv1215cat 1359.457 kb on - strandat 1359.457 kb on - strandat 1359.483 kb on - strandat 1359.515 kb on + strandat 1359.638 kb on - strand, within Rv1216cat 1359.668 kb on + strand, within Rv1216cat 1359.669 kb on - strand, within Rv1216cat 1359.693 kb on - strand, within Rv1216cat 1359.693 kb on - strand, within Rv1216cat 1359.693 kb on - strand, within Rv1216cat 1359.712 kb on + strand, within Rv1216cat 1359.713 kb on - strand, within Rv1216cat 1359.749 kb on + strand, within Rv1216cat 1359.750 kb on - strand, within Rv1216cat 1359.849 kb on - strand, within Rv1216cat 1359.995 kb on + strand, within Rv1216cat 1359.996 kb on - strand, within Rv1216cat 1360.121 kb on - strandat 1360.126 kb on + strandat 1360.126 kb on + strandat 1360.157 kb on - strandat 1360.336 kb on + strand, within Rv1217cat 1360.423 kb on - strand, within Rv1217c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Hydrogen peroxide 3.97 mM
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1,357,049 - -0.5
1,357,423 - Rv1214c 0.39 -0.7
1,357,423 - Rv1214c 0.39 +0.3
1,357,458 - Rv1214c 0.50 +1.7
1,357,469 - Rv1214c 0.53 -0.9
1,357,469 - Rv1214c 0.53 -1.2
1,357,645 - -0.2
1,357,913 - -0.3
1,358,105 + Rv1215c 0.21 +2.1
1,358,339 + Rv1215c 0.34 +1.1
1,358,507 + Rv1215c 0.44 -0.0
1,358,540 + Rv1215c 0.46 +0.1
1,358,540 + Rv1215c 0.46 +1.2
1,358,541 - Rv1215c 0.46 +1.1
1,358,723 + Rv1215c 0.57 -0.3
1,358,723 + Rv1215c 0.57 -0.4
1,358,724 - Rv1215c 0.57 -0.5
1,358,901 - Rv1215c 0.68 -0.1
1,358,901 - Rv1215c 0.68 +0.0
1,358,901 - Rv1215c 0.68 -0.4
1,359,147 - Rv1215c 0.82 -0.4
1,359,457 - +0.7
1,359,457 - -1.3
1,359,483 - +1.1
1,359,515 + +0.4
1,359,638 - Rv1216c 0.25 -0.8
1,359,668 + Rv1216c 0.29 +0.8
1,359,669 - Rv1216c 0.29 -0.1
1,359,693 - Rv1216c 0.33 -0.3
1,359,693 - Rv1216c 0.33 +1.9
1,359,693 - Rv1216c 0.33 +0.3
1,359,712 + Rv1216c 0.36 -0.4
1,359,713 - Rv1216c 0.36 -0.2
1,359,749 + Rv1216c 0.41 +1.5
1,359,750 - Rv1216c 0.41 -0.7
1,359,849 - Rv1216c 0.56 -1.8
1,359,995 + Rv1216c 0.77 -0.4
1,359,996 - Rv1216c 0.78 -0.2
1,360,121 - +0.0
1,360,126 + -1.2
1,360,126 + +2.3
1,360,157 - -0.5
1,360,336 + Rv1217c 0.11 -0.2
1,360,423 - Rv1217c 0.16 -0.8

Or see this region's nucleotide sequence