Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0182c

Experiment: 7H9 with Hydrogen peroxide 3.97 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0180c and Rv0181c are separated by 26 nucleotidesRv0181c and Rv0182c are separated by 16 nucleotidesRv0182c and Rv0183 overlap by 53 nucleotidesRv0183 and Rv0184 are separated by 41 nucleotides Rv0180c: Rv0180c - Probable conserved transmembrane protein, at 210,892 to 212,250 Rv0180c Rv0181c: Rv0181c - Conserved hypothetical protein, at 212,277 to 213,011 Rv0181c Rv0182c: Rv0182c - Probable alternative RNA polymerase sigma factor SigG (RNA polymerase ECF type sigma factor), at 213,028 to 214,140 Rv0182c Rv0183: Rv0183 - Possible lysophospholipase, at 214,088 to 214,927 Rv0183 Rv0184: Rv0184 - Conserved hypothetical protein, at 214,969 to 215,718 Rv0184 Position (kb) 213 214 215Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 212.278 kb on + strandat 212.278 kb on + strandat 212.278 kb on + strandat 212.278 kb on + strandat 212.279 kb on - strandat 212.279 kb on - strandat 212.279 kb on - strandat 212.279 kb on - strandat 212.279 kb on - strandat 212.279 kb on - strandat 212.323 kb on - strandat 212.569 kb on - strand, within Rv0181cat 212.598 kb on + strand, within Rv0181cat 212.599 kb on - strand, within Rv0181cat 212.614 kb on + strand, within Rv0181cat 212.615 kb on - strand, within Rv0181cat 212.615 kb on - strand, within Rv0181cat 212.644 kb on - strand, within Rv0181cat 212.747 kb on - strand, within Rv0181cat 212.914 kb on + strand, within Rv0181cat 212.915 kb on - strand, within Rv0181cat 212.991 kb on + strandat 212.992 kb on - strandat 213.124 kb on + strandat 213.161 kb on + strand, within Rv0182cat 213.161 kb on + strand, within Rv0182cat 213.162 kb on - strand, within Rv0182cat 213.162 kb on - strand, within Rv0182cat 213.275 kb on + strand, within Rv0182cat 213.287 kb on + strand, within Rv0182cat 213.287 kb on + strand, within Rv0182cat 213.287 kb on + strand, within Rv0182cat 213.288 kb on - strand, within Rv0182cat 213.348 kb on - strand, within Rv0182cat 213.367 kb on - strand, within Rv0182cat 213.367 kb on - strand, within Rv0182cat 213.475 kb on - strand, within Rv0182cat 213.475 kb on - strand, within Rv0182cat 213.554 kb on - strand, within Rv0182cat 213.821 kb on - strand, within Rv0182cat 213.848 kb on + strand, within Rv0182cat 213.849 kb on - strand, within Rv0182cat 213.849 kb on - strand, within Rv0182cat 213.849 kb on - strand, within Rv0182cat 213.921 kb on - strand, within Rv0182cat 214.087 kb on - strandat 214.093 kb on + strandat 214.093 kb on + strandat 214.145 kb on + strandat 214.146 kb on - strandat 214.146 kb on - strandat 214.268 kb on + strand, within Rv0183at 214.268 kb on + strand, within Rv0183at 214.317 kb on + strand, within Rv0183at 214.318 kb on - strand, within Rv0183at 214.318 kb on - strand, within Rv0183at 214.383 kb on - strand, within Rv0183at 214.442 kb on + strand, within Rv0183at 214.444 kb on - strand, within Rv0183at 214.466 kb on + strand, within Rv0183at 214.466 kb on + strand, within Rv0183at 214.467 kb on - strand, within Rv0183at 214.628 kb on + strand, within Rv0183at 214.628 kb on + strand, within Rv0183at 214.629 kb on - strand, within Rv0183at 214.629 kb on - strand, within Rv0183at 214.629 kb on - strand, within Rv0183at 214.744 kb on - strand, within Rv0183at 214.744 kb on - strand, within Rv0183

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Hydrogen peroxide 3.97 mM
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212,278 + +0.0
212,278 + -0.1
212,278 + +0.3
212,278 + +0.4
212,279 - +1.6
212,279 - -1.4
212,279 - -0.8
212,279 - -0.8
212,279 - +1.9
212,279 - -0.9
212,323 - -0.4
212,569 - Rv0181c 0.40 -0.3
212,598 + Rv0181c 0.44 -0.6
212,599 - Rv0181c 0.44 -0.1
212,614 + Rv0181c 0.46 +2.0
212,615 - Rv0181c 0.46 -0.5
212,615 - Rv0181c 0.46 +0.1
212,644 - Rv0181c 0.50 +0.2
212,747 - Rv0181c 0.64 +0.7
212,914 + Rv0181c 0.87 +2.3
212,915 - Rv0181c 0.87 -1.3
212,991 + -0.3
212,992 - -0.0
213,124 + +0.1
213,161 + Rv0182c 0.12 -0.3
213,161 + Rv0182c 0.12 +2.0
213,162 - Rv0182c 0.12 +0.1
213,162 - Rv0182c 0.12 +0.1
213,275 + Rv0182c 0.22 +1.1
213,287 + Rv0182c 0.23 +1.4
213,287 + Rv0182c 0.23 -0.5
213,287 + Rv0182c 0.23 -0.1
213,288 - Rv0182c 0.23 +0.1
213,348 - Rv0182c 0.29 +0.4
213,367 - Rv0182c 0.30 +1.7
213,367 - Rv0182c 0.30 -0.7
213,475 - Rv0182c 0.40 +0.6
213,475 - Rv0182c 0.40 -0.3
213,554 - Rv0182c 0.47 -2.1
213,821 - Rv0182c 0.71 +0.0
213,848 + Rv0182c 0.74 +0.5
213,849 - Rv0182c 0.74 -0.7
213,849 - Rv0182c 0.74 +0.4
213,849 - Rv0182c 0.74 +0.2
213,921 - Rv0182c 0.80 +1.0
214,087 - -3.1
214,093 + -0.4
214,093 + +0.2
214,145 + -0.4
214,146 - -0.3
214,146 - +0.6
214,268 + Rv0183 0.21 +0.0
214,268 + Rv0183 0.21 -0.6
214,317 + Rv0183 0.27 -0.4
214,318 - Rv0183 0.27 -2.9
214,318 - Rv0183 0.27 -0.7
214,383 - Rv0183 0.35 -0.1
214,442 + Rv0183 0.42 +0.6
214,444 - Rv0183 0.42 -0.5
214,466 + Rv0183 0.45 -0.2
214,466 + Rv0183 0.45 -0.4
214,467 - Rv0183 0.45 +0.9
214,628 + Rv0183 0.64 -0.1
214,628 + Rv0183 0.64 -0.2
214,629 - Rv0183 0.64 -0.7
214,629 - Rv0183 0.64 +0.1
214,629 - Rv0183 0.64 -0.5
214,744 - Rv0183 0.78 -0.0
214,744 - Rv0183 0.78 +0.3

Or see this region's nucleotide sequence