Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2118c

Experiment: 7H9 with Menadione 0.005 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2116 and Rv2117 are separated by 7 nucleotidesRv2117 and Rv2118c are separated by 28 nucleotidesRv2118c and Rv2119 are separated by 73 nucleotidesRv2119 and Rv2120c are separated by 22 nucleotides Rv2116: Rv2116 - Conserved lipoprotein LppK, at 2,376,571 to 2,377,140 Rv2116 Rv2117: Rv2117 - Conserved hypothetical protein, at 2,377,148 to 2,377,441 Rv2117 Rv2118c: Rv2118c - RNA methyltransferase, at 2,377,470 to 2,378,312 Rv2118c Rv2119: Rv2119 - Conserved hypothetical protein, at 2,378,386 to 2,379,222 Rv2119 Rv2120c: Rv2120c - Probable conserved integral membrane protein, at 2,379,245 to 2,379,727 Rv2120c Position (kb) 2377 2378 2379Strain fitness (log2 ratio) -3 -2 -1 0 1at 2376.485 kb on - strandat 2376.591 kb on - strandat 2376.591 kb on - strandat 2376.881 kb on - strand, within Rv2116at 2376.881 kb on - strand, within Rv2116at 2377.039 kb on - strand, within Rv2116at 2377.072 kb on - strand, within Rv2116at 2377.439 kb on + strandat 2377.440 kb on - strandat 2377.440 kb on - strandat 2377.494 kb on - strandat 2377.494 kb on - strandat 2377.559 kb on + strand, within Rv2118cat 2377.600 kb on - strand, within Rv2118cat 2377.708 kb on + strand, within Rv2118cat 2377.709 kb on - strand, within Rv2118cat 2377.924 kb on + strand, within Rv2118cat 2378.022 kb on + strand, within Rv2118cat 2378.022 kb on + strand, within Rv2118cat 2378.023 kb on - strand, within Rv2118cat 2378.062 kb on + strand, within Rv2118cat 2378.062 kb on + strand, within Rv2118cat 2378.099 kb on - strand, within Rv2118cat 2378.375 kb on - strandat 2378.468 kb on + strandat 2378.469 kb on - strandat 2378.469 kb on - strandat 2378.469 kb on - strandat 2378.522 kb on + strand, within Rv2119at 2378.560 kb on + strand, within Rv2119at 2378.561 kb on - strand, within Rv2119at 2378.561 kb on - strand, within Rv2119at 2378.561 kb on - strand, within Rv2119at 2378.561 kb on - strand, within Rv2119at 2378.720 kb on - strand, within Rv2119at 2378.722 kb on + strand, within Rv2119at 2378.863 kb on + strand, within Rv2119at 2378.863 kb on + strand, within Rv2119at 2378.863 kb on + strand, within Rv2119at 2378.864 kb on - strand, within Rv2119at 2378.910 kb on + strand, within Rv2119at 2378.911 kb on - strand, within Rv2119at 2378.992 kb on + strand, within Rv2119at 2378.993 kb on - strand, within Rv2119at 2379.041 kb on + strand, within Rv2119at 2379.082 kb on - strand, within Rv2119at 2379.248 kb on + strandat 2379.248 kb on + strandat 2379.248 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Menadione 0.005 mM
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2,376,485 - +0.3
2,376,591 - +1.4
2,376,591 - -0.2
2,376,881 - Rv2116 0.54 -0.6
2,376,881 - Rv2116 0.54 -1.4
2,377,039 - Rv2116 0.82 +0.0
2,377,072 - Rv2116 0.88 -0.3
2,377,439 + -1.8
2,377,440 - +0.2
2,377,440 - -0.3
2,377,494 - +0.0
2,377,494 - +1.0
2,377,559 + Rv2118c 0.11 +0.1
2,377,600 - Rv2118c 0.15 -0.4
2,377,708 + Rv2118c 0.28 +0.2
2,377,709 - Rv2118c 0.28 +0.2
2,377,924 + Rv2118c 0.54 +0.2
2,378,022 + Rv2118c 0.65 -1.8
2,378,022 + Rv2118c 0.65 +0.1
2,378,023 - Rv2118c 0.66 -2.8
2,378,062 + Rv2118c 0.70 +0.1
2,378,062 + Rv2118c 0.70 -0.5
2,378,099 - Rv2118c 0.75 +0.5
2,378,375 - +0.2
2,378,468 + +1.5
2,378,469 - -0.2
2,378,469 - -0.2
2,378,469 - -2.3
2,378,522 + Rv2119 0.16 -0.5
2,378,560 + Rv2119 0.21 +1.3
2,378,561 - Rv2119 0.21 +0.3
2,378,561 - Rv2119 0.21 -0.2
2,378,561 - Rv2119 0.21 +0.3
2,378,561 - Rv2119 0.21 +1.6
2,378,720 - Rv2119 0.40 +0.8
2,378,722 + Rv2119 0.40 -0.6
2,378,863 + Rv2119 0.57 -0.4
2,378,863 + Rv2119 0.57 +0.0
2,378,863 + Rv2119 0.57 -0.1
2,378,864 - Rv2119 0.57 -0.5
2,378,910 + Rv2119 0.63 -0.0
2,378,911 - Rv2119 0.63 -0.5
2,378,992 + Rv2119 0.72 -0.4
2,378,993 - Rv2119 0.73 +1.1
2,379,041 + Rv2119 0.78 +0.7
2,379,082 - Rv2119 0.83 +0.2
2,379,248 + -0.2
2,379,248 + -0.7
2,379,248 + +0.8

Or see this region's nucleotide sequence