Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3849

Experiment: 7H9 with Antimycin A 0.0186 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3848 and Rv3849 are separated by 264 nucleotidesRv3849 and Rv3850 are separated by 117 nucleotidesRv3850 and Rv3851 are separated by 11 nucleotides Rv3848: Rv3848 - Probable conserved transmembrane protein, at 4,322,326 to 4,323,234 Rv3848 Rv3849: Rv3849 - ESX-1 transcriptional regulatory protein EspR, at 4,323,499 to 4,323,897 Rv3849 Rv3850: Rv3850 - Conserved protein, at 4,324,015 to 4,324,671 Rv3850 Rv3851: Rv3851 - Possible membrane protein, at 4,324,683 to 4,324,967 Rv3851 Position (kb) 4323 4324Strain fitness (log2 ratio) -1 0 1 2at 4322.736 kb on - strand, within Rv3848at 4322.736 kb on - strand, within Rv3848at 4323.297 kb on + strandat 4323.547 kb on + strand, within Rv3849at 4323.896 kb on - strandat 4323.959 kb on - strandat 4324.235 kb on + strand, within Rv3850at 4324.326 kb on - strand, within Rv3850at 4324.327 kb on + strand, within Rv3850at 4324.670 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Antimycin A 0.0186 mM
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4,322,736 - Rv3848 0.45 +0.8
4,322,736 - Rv3848 0.45 +1.5
4,323,297 + -0.6
4,323,547 + Rv3849 0.12 +0.2
4,323,896 - +0.4
4,323,959 - -0.1
4,324,235 + Rv3850 0.33 +1.9
4,324,326 - Rv3850 0.47 -1.5
4,324,327 + Rv3850 0.47 -0.1
4,324,670 - +0.3

Or see this region's nucleotide sequence