Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3738c

Experiment: 7H9 with Cloxacillin 0.0386 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3737 and Rv3738c overlap by 4 nucleotidesRv3738c and Rv3739c are separated by 51 nucleotidesRv3739c and Rv3740c are separated by 315 nucleotides Rv3737: Rv3737 - Probable conserved transmembrane protein, at 4,187,699 to 4,189,288 Rv3737 Rv3738c: Rv3738c - PPE family protein PPE66, at 4,189,285 to 4,190,232 Rv3738c Rv3739c: Rv3739c - PPE family protein PPE67, at 4,190,284 to 4,190,517 Rv3739c Rv3740c: Rv3740c - Possible triacylglycerol synthase (diacylglycerol acyltransferase), at 4,190,833 to 4,192,179 Rv3740c Position (kb) 4189 4190 4191Strain fitness (log2 ratio) -1 0 1 2at 4188.374 kb on + strand, within Rv3737at 4188.374 kb on + strand, within Rv3737at 4188.480 kb on - strand, within Rv3737at 4188.702 kb on - strand, within Rv3737at 4188.702 kb on - strand, within Rv3737at 4188.702 kb on - strand, within Rv3737at 4188.711 kb on + strand, within Rv3737at 4189.258 kb on + strandat 4189.568 kb on - strand, within Rv3738cat 4189.598 kb on - strand, within Rv3738cat 4189.842 kb on - strand, within Rv3738cat 4189.842 kb on - strand, within Rv3738cat 4190.048 kb on + strand, within Rv3738cat 4190.048 kb on + strand, within Rv3738cat 4190.049 kb on - strand, within Rv3738cat 4190.049 kb on - strand, within Rv3738cat 4190.049 kb on - strand, within Rv3738cat 4190.049 kb on - strand, within Rv3738cat 4190.052 kb on + strand, within Rv3738cat 4190.052 kb on + strand, within Rv3738cat 4190.052 kb on + strand, within Rv3738cat 4190.052 kb on + strand, within Rv3738cat 4190.052 kb on + strand, within Rv3738cat 4190.052 kb on + strand, within Rv3738cat 4190.052 kb on + strand, within Rv3738cat 4190.053 kb on - strand, within Rv3738cat 4190.090 kb on + strand, within Rv3738cat 4190.091 kb on - strand, within Rv3738cat 4190.091 kb on - strand, within Rv3738cat 4190.122 kb on - strand, within Rv3738cat 4190.173 kb on - strandat 4190.219 kb on + strandat 4190.219 kb on + strandat 4190.232 kb on + strandat 4190.233 kb on - strandat 4190.315 kb on + strand, within Rv3739cat 4190.315 kb on + strand, within Rv3739cat 4190.315 kb on + strand, within Rv3739cat 4190.315 kb on + strand, within Rv3739cat 4190.316 kb on - strand, within Rv3739cat 4190.316 kb on - strand, within Rv3739cat 4190.316 kb on - strand, within Rv3739cat 4190.316 kb on - strand, within Rv3739cat 4190.316 kb on - strand, within Rv3739cat 4190.316 kb on - strand, within Rv3739cat 4190.353 kb on + strand, within Rv3739cat 4190.396 kb on + strand, within Rv3739cat 4190.517 kb on + strandat 4190.517 kb on + strandat 4190.517 kb on + strandat 4190.530 kb on + strandat 4190.583 kb on + strandat 4190.584 kb on - strandat 4190.584 kb on - strandat 4190.584 kb on - strandat 4190.605 kb on - strandat 4190.605 kb on - strandat 4190.690 kb on - strandat 4190.762 kb on + strandat 4190.762 kb on + strandat 4190.763 kb on - strandat 4190.763 kb on - strandat 4190.763 kb on - strandat 4190.763 kb on - strandat 4190.763 kb on - strandat 4190.773 kb on - strandat 4190.786 kb on - strandat 4191.006 kb on - strand, within Rv3740cat 4191.035 kb on + strand, within Rv3740cat 4191.078 kb on + strand, within Rv3740cat 4191.184 kb on + strand, within Rv3740cat 4191.188 kb on - strand, within Rv3740cat 4191.188 kb on - strand, within Rv3740cat 4191.195 kb on + strand, within Rv3740cat 4191.195 kb on + strand, within Rv3740cat 4191.195 kb on + strand, within Rv3740cat 4191.196 kb on - strand, within Rv3740cat 4191.196 kb on - strand, within Rv3740cat 4191.196 kb on - strand, within Rv3740cat 4191.198 kb on + strand, within Rv3740c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Cloxacillin 0.0386 mM
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4,188,374 + Rv3737 0.42 -0.2
4,188,374 + Rv3737 0.42 -0.8
4,188,480 - Rv3737 0.49 +0.1
4,188,702 - Rv3737 0.63 -0.2
4,188,702 - Rv3737 0.63 +0.3
4,188,702 - Rv3737 0.63 +0.0
4,188,711 + Rv3737 0.64 +1.1
4,189,258 + -0.7
4,189,568 - Rv3738c 0.30 +1.8
4,189,598 - Rv3738c 0.33 +0.6
4,189,842 - Rv3738c 0.59 -0.5
4,189,842 - Rv3738c 0.59 +0.3
4,190,048 + Rv3738c 0.80 -0.0
4,190,048 + Rv3738c 0.80 +0.1
4,190,049 - Rv3738c 0.81 +1.7
4,190,049 - Rv3738c 0.81 +0.4
4,190,049 - Rv3738c 0.81 +1.3
4,190,049 - Rv3738c 0.81 +1.0
4,190,052 + Rv3738c 0.81 -0.5
4,190,052 + Rv3738c 0.81 -0.1
4,190,052 + Rv3738c 0.81 -0.1
4,190,052 + Rv3738c 0.81 -0.3
4,190,052 + Rv3738c 0.81 +0.5
4,190,052 + Rv3738c 0.81 -0.1
4,190,052 + Rv3738c 0.81 -0.4
4,190,053 - Rv3738c 0.81 -0.0
4,190,090 + Rv3738c 0.85 +0.2
4,190,091 - Rv3738c 0.85 +0.0
4,190,091 - Rv3738c 0.85 +0.4
4,190,122 - Rv3738c 0.88 +0.5
4,190,173 - +0.4
4,190,219 + +0.3
4,190,219 + +1.6
4,190,232 + -1.0
4,190,233 - -0.4
4,190,315 + Rv3739c 0.13 -0.0
4,190,315 + Rv3739c 0.13 -0.2
4,190,315 + Rv3739c 0.13 -0.3
4,190,315 + Rv3739c 0.13 +0.2
4,190,316 - Rv3739c 0.14 +0.0
4,190,316 - Rv3739c 0.14 -0.7
4,190,316 - Rv3739c 0.14 -0.2
4,190,316 - Rv3739c 0.14 +1.0
4,190,316 - Rv3739c 0.14 +2.6
4,190,316 - Rv3739c 0.14 -0.4
4,190,353 + Rv3739c 0.29 +0.7
4,190,396 + Rv3739c 0.48 -0.2
4,190,517 + +1.3
4,190,517 + +0.6
4,190,517 + -1.0
4,190,530 + -0.4
4,190,583 + -0.4
4,190,584 - +0.4
4,190,584 - -0.1
4,190,584 - -1.2
4,190,605 - -1.5
4,190,605 - +0.3
4,190,690 - -0.8
4,190,762 + -0.0
4,190,762 + +0.0
4,190,763 - +0.4
4,190,763 - -0.4
4,190,763 - -0.3
4,190,763 - +0.1
4,190,763 - +1.2
4,190,773 - +0.1
4,190,786 - +0.7
4,191,006 - Rv3740c 0.13 +0.0
4,191,035 + Rv3740c 0.15 -0.2
4,191,078 + Rv3740c 0.18 +0.7
4,191,184 + Rv3740c 0.26 -1.0
4,191,188 - Rv3740c 0.26 +0.4
4,191,188 - Rv3740c 0.26 -0.3
4,191,195 + Rv3740c 0.27 +0.6
4,191,195 + Rv3740c 0.27 -0.1
4,191,195 + Rv3740c 0.27 -0.2
4,191,196 - Rv3740c 0.27 -0.1
4,191,196 - Rv3740c 0.27 +0.6
4,191,196 - Rv3740c 0.27 -1.1
4,191,198 + Rv3740c 0.27 -0.1

Or see this region's nucleotide sequence