Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2881c

Experiment: 7H9 with Cloxacillin 0.0386 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2879c and Rv2880c overlap by 302 nucleotidesRv2880c and Rv2881c are separated by 22 nucleotidesRv2881c and Rv2882c are separated by 22 nucleotidesRv2882c and Rv2883c are separated by 171 nucleotides Rv2879c: Rv2879c - Conserved hypothetical protein, at 3,189,583 to 3,190,152 Rv2879c Rv2880c: Rv2880c - Conserved hypothetical protein, at 3,189,851 to 3,190,678 Rv2880c Rv2881c: Rv2881c - Probable integral membrane phosphatidate cytidylyltransferase CdsA (CDP-diglyceride synthetase) (CDP-diglyceride pyrophosphorylase) (CDP-diacylglycerol synthase) (CDS) (CTP:phosphatidate cytidylyltransferase) (CDP-DAG synthase) (CDP-DG synthetase), at 3,190,701 to 3,191,621 Rv2881c Rv2882c: Rv2882c - Ribosome recycling factor Frr (ribosome releasing factor) (RRF), at 3,191,644 to 3,192,201 Rv2882c Rv2883c: Rv2883c - Probable uridylate kinase PyrH (UK) (uridine monophosphate kinase) (UMP kinase), at 3,192,373 to 3,193,158 Rv2883c Position (kb) 3190 3191 3192Strain fitness (log2 ratio) -1 0 1at 3189.848 kb on + strand, within Rv2879cat 3189.856 kb on - strandat 3189.940 kb on + strandat 3189.940 kb on + strandat 3189.940 kb on + strandat 3189.941 kb on - strandat 3189.941 kb on - strandat 3189.941 kb on - strandat 3190.130 kb on + strandat 3190.130 kb on + strandat 3190.130 kb on + strandat 3190.131 kb on - strandat 3190.372 kb on + strand, within Rv2880cat 3190.373 kb on - strand, within Rv2880cat 3190.442 kb on - strand, within Rv2880cat 3190.533 kb on + strand, within Rv2880cat 3190.533 kb on + strand, within Rv2880cat 3190.533 kb on + strand, within Rv2880cat 3190.534 kb on - strand, within Rv2880cat 3190.536 kb on + strand, within Rv2880cat 3190.536 kb on + strand, within Rv2880cat 3190.537 kb on - strand, within Rv2880cat 3190.537 kb on - strand, within Rv2880cat 3190.537 kb on - strand, within Rv2880cat 3192.375 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Cloxacillin 0.0386 mM
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3,189,848 + Rv2879c 0.46 -1.2
3,189,856 - +0.5
3,189,940 + -0.7
3,189,940 + -0.4
3,189,940 + -0.3
3,189,941 - +1.6
3,189,941 - -1.6
3,189,941 - -0.2
3,190,130 + +0.1
3,190,130 + -0.4
3,190,130 + -0.6
3,190,131 - -0.6
3,190,372 + Rv2880c 0.63 -0.6
3,190,373 - Rv2880c 0.63 -0.1
3,190,442 - Rv2880c 0.71 +0.1
3,190,533 + Rv2880c 0.82 +0.4
3,190,533 + Rv2880c 0.82 -1.4
3,190,533 + Rv2880c 0.82 -0.4
3,190,534 - Rv2880c 0.82 -0.1
3,190,536 + Rv2880c 0.83 -0.3
3,190,536 + Rv2880c 0.83 -0.0
3,190,537 - Rv2880c 0.83 -0.2
3,190,537 - Rv2880c 0.83 -0.4
3,190,537 - Rv2880c 0.83 -0.4
3,192,375 - +0.2

Or see this region's nucleotide sequence