Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0427c

Experiment: 7H9 with Cloxacillin 0.0386 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0425c and Rv0426c are separated by 51 nucleotidesRv0426c and Rv0427c are separated by 200 nucleotidesRv0427c and Rv0428c are separated by 2 nucleotidesRv0428c and Rv0429c overlap by 1 nucleotides Rv0425c: Rv0425c - Possible metal cation transporting P-type ATPase CtpH, at 510,702 to 515,321 Rv0425c Rv0426c: Rv0426c - Possible transmembrane protein, at 515,373 to 515,816 Rv0426c Rv0427c: Rv0427c - Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI), at 516,017 to 516,892 Rv0427c Rv0428c: Rv0428c - GCN5-related N-acetyltransferase, at 516,895 to 517,803 Rv0428c Rv0429c: Rv0429c - Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase), at 517,803 to 518,396 Rv0429c Position (kb) 516 517Strain fitness (log2 ratio) -1 0 1 2at 515.204 kb on + strandat 515.375 kb on - strandat 515.550 kb on + strand, within Rv0426cat 515.660 kb on + strand, within Rv0426cat 515.660 kb on + strand, within Rv0426cat 515.661 kb on - strand, within Rv0426cat 515.847 kb on + strandat 516.199 kb on - strand, within Rv0427cat 516.230 kb on + strand, within Rv0427cat 516.441 kb on + strand, within Rv0427cat 516.669 kb on + strand, within Rv0427cat 516.896 kb on + strandat 516.904 kb on - strandat 516.932 kb on + strandat 517.007 kb on + strand, within Rv0428cat 517.181 kb on + strand, within Rv0428cat 517.181 kb on + strand, within Rv0428cat 517.182 kb on - strand, within Rv0428cat 517.182 kb on - strand, within Rv0428cat 517.235 kb on - strand, within Rv0428cat 517.465 kb on - strand, within Rv0428cat 517.474 kb on + strand, within Rv0428cat 517.495 kb on + strand, within Rv0428cat 517.760 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Cloxacillin 0.0386 mM
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515,204 + -0.8
515,375 - -0.3
515,550 + Rv0426c 0.40 +0.2
515,660 + Rv0426c 0.65 -0.1
515,660 + Rv0426c 0.65 -0.7
515,661 - Rv0426c 0.65 -0.1
515,847 + -0.7
516,199 - Rv0427c 0.21 +0.7
516,230 + Rv0427c 0.24 +0.9
516,441 + Rv0427c 0.48 +0.7
516,669 + Rv0427c 0.74 -0.3
516,896 + +1.9
516,904 - +0.5
516,932 + +0.5
517,007 + Rv0428c 0.12 -0.1
517,181 + Rv0428c 0.31 +1.6
517,181 + Rv0428c 0.31 +0.9
517,182 - Rv0428c 0.32 -0.1
517,182 - Rv0428c 0.32 +0.0
517,235 - Rv0428c 0.37 +0.1
517,465 - Rv0428c 0.63 -0.3
517,474 + Rv0428c 0.64 -1.2
517,495 + Rv0428c 0.66 +0.6
517,760 + -0.5

Or see this region's nucleotide sequence