Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2508c

Experiment: 7H9 with Dicloxacillin 0.0069 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2506 and Rv2507 are separated by 78 nucleotidesRv2507 and Rv2508c overlap by 4 nucleotidesRv2508c and Rv2509 are separated by 84 nucleotidesRv2509 and Rv2510c are separated by 3 nucleotides Rv2506: Rv2506 - Probable transcriptional regulatory protein (probably TetR-family), at 2,821,712 to 2,822,359 Rv2506 Rv2507: Rv2507 - Possible conserved proline rich membrane protein, at 2,822,438 to 2,823,259 Rv2507 Rv2508c: Rv2508c - Probable conserved integral membrane leucine and alanine rich protein, at 2,823,256 to 2,824,593 Rv2508c Rv2509: Rv2509 - Probable short-chain type dehydrogenase/reductase, at 2,824,678 to 2,825,484 Rv2509 Rv2510c: Rv2510c - Conserved protein, at 2,825,488 to 2,827,089 Rv2510c Position (kb) 2823 2824 2825Strain fitness (log2 ratio) -1 0 1 2 3at 2822.355 kb on + strandat 2822.356 kb on - strandat 2822.356 kb on - strandat 2822.356 kb on - strandat 2822.357 kb on + strandat 2822.357 kb on + strandat 2822.358 kb on - strandat 2822.358 kb on - strandat 2822.415 kb on - strandat 2823.443 kb on + strand, within Rv2508cat 2823.444 kb on - strand, within Rv2508cat 2823.483 kb on + strand, within Rv2508cat 2823.484 kb on - strand, within Rv2508cat 2823.484 kb on - strand, within Rv2508cat 2823.740 kb on + strand, within Rv2508cat 2823.821 kb on + strand, within Rv2508cat 2823.822 kb on - strand, within Rv2508cat 2823.822 kb on - strand, within Rv2508cat 2824.027 kb on + strand, within Rv2508cat 2824.057 kb on - strand, within Rv2508cat 2824.076 kb on + strand, within Rv2508cat 2824.109 kb on + strand, within Rv2508cat 2824.109 kb on + strand, within Rv2508cat 2824.185 kb on - strand, within Rv2508cat 2824.250 kb on + strand, within Rv2508cat 2824.606 kb on - strandat 2824.606 kb on - strandat 2824.658 kb on + strandat 2824.659 kb on - strandat 2824.659 kb on - strandat 2825.482 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Dicloxacillin 0.0069 mM
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2,822,355 + -0.4
2,822,356 - +1.8
2,822,356 - +0.2
2,822,356 - +0.7
2,822,357 + -0.2
2,822,357 + -0.1
2,822,358 - -1.5
2,822,358 - -0.3
2,822,415 - -0.3
2,823,443 + Rv2508c 0.14 -0.1
2,823,444 - Rv2508c 0.14 -0.5
2,823,483 + Rv2508c 0.17 -0.2
2,823,484 - Rv2508c 0.17 +0.5
2,823,484 - Rv2508c 0.17 -0.0
2,823,740 + Rv2508c 0.36 -0.2
2,823,821 + Rv2508c 0.42 +3.4
2,823,822 - Rv2508c 0.42 +0.2
2,823,822 - Rv2508c 0.42 -0.3
2,824,027 + Rv2508c 0.58 +0.1
2,824,057 - Rv2508c 0.60 +1.3
2,824,076 + Rv2508c 0.61 +1.2
2,824,109 + Rv2508c 0.64 +0.3
2,824,109 + Rv2508c 0.64 +1.8
2,824,185 - Rv2508c 0.69 -0.1
2,824,250 + Rv2508c 0.74 +1.7
2,824,606 - +0.0
2,824,606 - -1.0
2,824,658 + -1.0
2,824,659 - +0.1
2,824,659 - +0.1
2,825,482 + -0.2

Or see this region's nucleotide sequence