Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2985

Experiment: 7H9 with Novobiocin 0.004 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2984 and Rv2985 are separated by 82 nucleotidesRv2985 and Rv2986c are separated by 57 nucleotidesRv2986c and Rv2987c are separated by 212 nucleotides Rv2984: Rv2984 - Polyphosphate kinase PPK (polyphosphoric acid kinase) (ATP-polyphosphate phosphotransferase), at 3,339,854 to 3,342,082 Rv2984 Rv2985: Rv2985 - Possible hydrolase MutT1, at 3,342,165 to 3,343,118 Rv2985 Rv2986c: Rv2986c - DNA-binding protein HU homolog HupB (histone-like protein) (HLP) (21-kDa laminin-2-binding protein), at 3,343,176 to 3,343,820 Rv2986c Rv2987c: Rv2987c - Probable 3-isopropylmalate dehydratase (small subunit) LeuD (isopropylmalate isomerase) (alpha-IPM isomerase) (IPMI), at 3,344,033 to 3,344,629 Rv2987c Position (kb) 3342 3343 3344Strain fitness (log2 ratio) -1 0 1at 3342.374 kb on - strand, within Rv2985at 3342.839 kb on - strand, within Rv2985

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Novobiocin 0.004 mM
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3,342,374 - Rv2985 0.22 -0.8
3,342,839 - Rv2985 0.71 -1.0

Or see this region's nucleotide sequence