Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2073c

Experiment: 7H9 with Novobiocin 0.004 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2072c and Rv2073c are separated by 67 nucleotidesRv2073c and Rv2074 are separated by 29 nucleotidesRv2074 and Rv2075c are separated by 9 nucleotides Rv2072c: Rv2072c - Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL, at 2,328,974 to 2,330,146 Rv2072c Rv2073c: Rv2073c - Probable shortchain dehydrogenase, at 2,330,214 to 2,330,963 Rv2073c Rv2074: Rv2074 - Possible pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase), at 2,330,993 to 2,331,406 Rv2074 Rv2075c: Rv2075c - Possible hypothetical exported or envelope protein, at 2,331,416 to 2,332,879 Rv2075c Position (kb) 2330 2331Strain fitness (log2 ratio) -2 -1 0 1at 2329.540 kb on - strand, within Rv2072cat 2329.943 kb on + strand, within Rv2072cat 2330.307 kb on - strand, within Rv2073cat 2330.506 kb on + strand, within Rv2073cat 2330.506 kb on + strand, within Rv2073cat 2330.506 kb on + strand, within Rv2073cat 2330.506 kb on + strand, within Rv2073cat 2330.507 kb on - strand, within Rv2073cat 2330.507 kb on - strand, within Rv2073cat 2330.507 kb on - strand, within Rv2073cat 2330.507 kb on - strand, within Rv2073cat 2330.507 kb on - strand, within Rv2073cat 2330.507 kb on - strand, within Rv2073cat 2330.507 kb on - strand, within Rv2073cat 2330.620 kb on + strand, within Rv2073cat 2330.799 kb on + strand, within Rv2073cat 2330.799 kb on + strand, within Rv2073cat 2330.801 kb on + strand, within Rv2073cat 2330.935 kb on - strandat 2330.937 kb on + strandat 2330.973 kb on + strandat 2330.974 kb on - strandat 2331.013 kb on + strandat 2331.013 kb on + strandat 2331.014 kb on - strandat 2331.428 kb on + strandat 2331.429 kb on - strandat 2331.429 kb on - strandat 2331.432 kb on + strandat 2331.432 kb on + strandat 2331.432 kb on + strandat 2331.433 kb on - strandat 2331.509 kb on - strandat 2331.806 kb on - strand, within Rv2075cat 2331.874 kb on - strand, within Rv2075cat 2331.876 kb on + strand, within Rv2075cat 2331.897 kb on + strand, within Rv2075cat 2331.898 kb on - strand, within Rv2075cat 2331.898 kb on - strand, within Rv2075c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Novobiocin 0.004 mM
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2,329,540 - Rv2072c 0.48 -0.2
2,329,943 + Rv2072c 0.83 +0.1
2,330,307 - Rv2073c 0.12 -0.4
2,330,506 + Rv2073c 0.39 -1.2
2,330,506 + Rv2073c 0.39 -1.6
2,330,506 + Rv2073c 0.39 -1.2
2,330,506 + Rv2073c 0.39 -0.7
2,330,507 - Rv2073c 0.39 +1.0
2,330,507 - Rv2073c 0.39 -0.3
2,330,507 - Rv2073c 0.39 -0.0
2,330,507 - Rv2073c 0.39 -0.5
2,330,507 - Rv2073c 0.39 -0.3
2,330,507 - Rv2073c 0.39 -0.6
2,330,507 - Rv2073c 0.39 -0.3
2,330,620 + Rv2073c 0.54 -0.9
2,330,799 + Rv2073c 0.78 -0.6
2,330,799 + Rv2073c 0.78 -0.4
2,330,801 + Rv2073c 0.78 +0.0
2,330,935 - +0.0
2,330,937 + -0.2
2,330,973 + -0.5
2,330,974 - -0.4
2,331,013 + +0.2
2,331,013 + +0.3
2,331,014 - -0.0
2,331,428 + -0.6
2,331,429 - -0.3
2,331,429 - +0.4
2,331,432 + -1.9
2,331,432 + -0.5
2,331,432 + +0.2
2,331,433 - -1.3
2,331,509 - -0.5
2,331,806 - Rv2075c 0.27 +0.3
2,331,874 - Rv2075c 0.31 -0.1
2,331,876 + Rv2075c 0.31 -0.1
2,331,897 + Rv2075c 0.33 +0.2
2,331,898 - Rv2075c 0.33 -1.7
2,331,898 - Rv2075c 0.33 -0.2

Or see this region's nucleotide sequence