Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1401

Experiment: 7H9 with Novobiocin 0.004 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1400c and Rv1401 are separated by 133 nucleotidesRv1401 and Rv1402 are separated by 80 nucleotides Rv1400c: Rv1400c - Probable lipase LipH, at 1,575,834 to 1,576,796 Rv1400c Rv1401: Rv1401 - Possible membrane protein, at 1,576,930 to 1,577,532 Rv1401 Rv1402: Rv1402 - Putative primosomal protein N, at 1,577,613 to 1,579,580 Rv1402 Position (kb) 1576 1577 1578Strain fitness (log2 ratio) -1 0 1at 1576.121 kb on - strand, within Rv1400cat 1576.873 kb on + strandat 1577.281 kb on + strand, within Rv1401at 1577.281 kb on + strand, within Rv1401at 1577.520 kb on + strandat 1577.520 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Novobiocin 0.004 mM
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1,576,121 - Rv1400c 0.30 -0.5
1,576,873 + -0.2
1,577,281 + Rv1401 0.58 -0.1
1,577,281 + Rv1401 0.58 -0.8
1,577,520 + -0.5
1,577,520 + +0.3

Or see this region's nucleotide sequence