Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3894c

Experiment: 7H9 with Chloramphenicol 0.01 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3892c and Rv3893c are separated by 78 nucleotidesRv3893c and Rv3894c are separated by 266 nucleotidesRv3894c and Rv3895c are separated by 0 nucleotides Rv3892c: Rv3892c - PPE family protein PPE69, at 4,374,484 to 4,375,683 Rv3892c Rv3893c: Rv3893c - PE family protein PE36, at 4,375,762 to 4,375,995 Rv3893c Rv3894c: Rv3894c - ESX conserved component EccC2. ESX-2 type VII secretion system protein. Possible membrane protein., at 4,376,262 to 4,380,452 Rv3894c Rv3895c: Rv3895c - ESX conserved component EccB2. ESX-2 type VII secretion system protein. Probable membrane protein., at 4,380,453 to 4,381,940 Rv3895c Position (kb) 4376 4377 4378 4379 4380 4381Strain fitness (log2 ratio) -3 -2 -1 0 1 2 3 4at 4375.286 kb on - strand, within Rv3892cat 4375.477 kb on - strand, within Rv3892cat 4375.687 kb on + strandat 4375.687 kb on + strandat 4375.687 kb on + strandat 4375.687 kb on + strandat 4375.688 kb on - strandat 4375.688 kb on - strandat 4375.688 kb on - strandat 4375.688 kb on - strandat 4375.688 kb on - strandat 4375.688 kb on - strandat 4375.691 kb on + strandat 4375.739 kb on + strandat 4375.763 kb on + strandat 4375.764 kb on - strandat 4375.764 kb on - strandat 4375.814 kb on + strand, within Rv3893cat 4375.815 kb on - strand, within Rv3893cat 4375.887 kb on + strand, within Rv3893cat 4375.888 kb on - strand, within Rv3893cat 4376.042 kb on + strandat 4376.042 kb on + strandat 4376.043 kb on - strandat 4376.184 kb on - strandat 4376.232 kb on + strandat 4376.246 kb on - strandat 4376.402 kb on + strandat 4376.403 kb on - strandat 4376.404 kb on + strandat 4376.405 kb on - strandat 4376.405 kb on - strandat 4376.405 kb on - strandat 4376.405 kb on - strandat 4376.493 kb on + strandat 4376.494 kb on - strandat 4376.740 kb on + strand, within Rv3894cat 4376.741 kb on - strand, within Rv3894cat 4376.746 kb on + strand, within Rv3894cat 4376.746 kb on + strand, within Rv3894cat 4376.747 kb on - strand, within Rv3894cat 4376.747 kb on - strand, within Rv3894cat 4376.747 kb on - strand, within Rv3894cat 4376.759 kb on - strand, within Rv3894cat 4376.904 kb on + strand, within Rv3894cat 4376.905 kb on - strand, within Rv3894cat 4376.905 kb on - strand, within Rv3894cat 4377.439 kb on + strand, within Rv3894cat 4377.938 kb on - strand, within Rv3894cat 4378.021 kb on + strand, within Rv3894cat 4378.021 kb on + strand, within Rv3894cat 4378.022 kb on - strand, within Rv3894cat 4378.022 kb on - strand, within Rv3894cat 4378.022 kb on - strand, within Rv3894cat 4378.078 kb on + strand, within Rv3894cat 4378.078 kb on + strand, within Rv3894cat 4378.078 kb on + strand, within Rv3894cat 4378.157 kb on - strand, within Rv3894cat 4378.250 kb on - strand, within Rv3894cat 4378.449 kb on + strand, within Rv3894cat 4378.652 kb on - strand, within Rv3894cat 4379.366 kb on + strand, within Rv3894cat 4379.366 kb on + strand, within Rv3894cat 4379.549 kb on + strand, within Rv3894cat 4379.983 kb on - strand, within Rv3894cat 4379.983 kb on - strand, within Rv3894cat 4380.140 kb on - strandat 4380.280 kb on + strandat 4380.280 kb on + strandat 4380.281 kb on - strandat 4380.454 kb on + strandat 4380.454 kb on + strandat 4380.798 kb on + strand, within Rv3895cat 4380.856 kb on + strand, within Rv3895cat 4381.040 kb on - strand, within Rv3895cat 4381.040 kb on - strand, within Rv3895cat 4381.112 kb on - strand, within Rv3895cat 4381.361 kb on - strand, within Rv3895cat 4381.361 kb on - strand, within Rv3895c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Chloramphenicol 0.01 mM
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4,375,286 - Rv3892c 0.67 -0.4
4,375,477 - Rv3892c 0.83 -1.1
4,375,687 + +0.4
4,375,687 + -0.7
4,375,687 + -0.7
4,375,687 + +0.0
4,375,688 - +0.2
4,375,688 - -0.0
4,375,688 - -0.5
4,375,688 - -1.1
4,375,688 - -0.7
4,375,688 - +0.7
4,375,691 + -1.7
4,375,739 + +0.1
4,375,763 + -0.1
4,375,764 - -0.6
4,375,764 - -0.5
4,375,814 + Rv3893c 0.22 -0.6
4,375,815 - Rv3893c 0.23 +0.8
4,375,887 + Rv3893c 0.53 -1.2
4,375,888 - Rv3893c 0.54 +0.8
4,376,042 + -0.7
4,376,042 + -0.7
4,376,043 - +0.2
4,376,184 - -0.5
4,376,232 + -0.2
4,376,246 - -0.4
4,376,402 + -0.2
4,376,403 - +1.1
4,376,404 + +0.1
4,376,405 - -0.5
4,376,405 - -0.0
4,376,405 - -1.4
4,376,405 - +0.8
4,376,493 + -0.3
4,376,494 - +0.0
4,376,740 + Rv3894c 0.11 -2.8
4,376,741 - Rv3894c 0.11 -0.0
4,376,746 + Rv3894c 0.12 +0.0
4,376,746 + Rv3894c 0.12 -0.3
4,376,747 - Rv3894c 0.12 +0.2
4,376,747 - Rv3894c 0.12 -0.0
4,376,747 - Rv3894c 0.12 -0.4
4,376,759 - Rv3894c 0.12 -0.4
4,376,904 + Rv3894c 0.15 -1.5
4,376,905 - Rv3894c 0.15 -0.1
4,376,905 - Rv3894c 0.15 +0.4
4,377,439 + Rv3894c 0.28 -0.5
4,377,938 - Rv3894c 0.40 +0.1
4,378,021 + Rv3894c 0.42 +1.2
4,378,021 + Rv3894c 0.42 +3.4
4,378,022 - Rv3894c 0.42 +0.1
4,378,022 - Rv3894c 0.42 +0.5
4,378,022 - Rv3894c 0.42 -1.0
4,378,078 + Rv3894c 0.43 +0.4
4,378,078 + Rv3894c 0.43 -0.4
4,378,078 + Rv3894c 0.43 +0.5
4,378,157 - Rv3894c 0.45 +0.8
4,378,250 - Rv3894c 0.47 -0.2
4,378,449 + Rv3894c 0.52 +0.1
4,378,652 - Rv3894c 0.57 +0.6
4,379,366 + Rv3894c 0.74 +1.0
4,379,366 + Rv3894c 0.74 +1.6
4,379,549 + Rv3894c 0.78 -0.2
4,379,983 - Rv3894c 0.89 +0.6
4,379,983 - Rv3894c 0.89 -0.1
4,380,140 - -0.8
4,380,280 + -0.3
4,380,280 + +0.3
4,380,281 - -0.7
4,380,454 + -0.7
4,380,454 + -0.1
4,380,798 + Rv3895c 0.23 -0.4
4,380,856 + Rv3895c 0.27 -0.4
4,381,040 - Rv3895c 0.39 +3.8
4,381,040 - Rv3895c 0.39 +0.9
4,381,112 - Rv3895c 0.44 -0.4
4,381,361 - Rv3895c 0.61 +1.8
4,381,361 - Rv3895c 0.61 +0.1

Or see this region's nucleotide sequence