Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3571

Experiment: 7H9 with Chloramphenicol 0.01 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3570c and Rv3571 are separated by 146 nucleotidesRv3571 and Rv3572 are separated by 17 nucleotidesRv3572 and Rv3573c are separated by 35 nucleotides Rv3570c: Rv3570c - Possible oxidoreductase. Possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase., at 4,011,086 to 4,012,270 Rv3570c Rv3571: Rv3571 - Reductase component of 3-ketosteroid-9-alpha-hydroxylase KshB, at 4,012,417 to 4,013,493 Rv3571 Rv3572: Rv3572 - Unknown protein, at 4,013,511 to 4,014,041 Rv3572 Rv3573c: Rv3573c - Probable acyl-CoA dehydrogenase FadE34, at 4,014,077 to 4,016,212 Rv3573c Position (kb) 4012 4013 4014Strain fitness (log2 ratio) -2 -1 0 1 2 3at 4011.584 kb on - strand, within Rv3570cat 4011.710 kb on + strand, within Rv3570cat 4011.710 kb on + strand, within Rv3570cat 4011.711 kb on - strand, within Rv3570cat 4011.723 kb on + strand, within Rv3570cat 4011.723 kb on + strand, within Rv3570cat 4011.724 kb on - strand, within Rv3570cat 4012.272 kb on + strandat 4012.272 kb on + strandat 4012.342 kb on - strandat 4012.615 kb on - strand, within Rv3571at 4012.960 kb on + strand, within Rv3571at 4012.961 kb on - strand, within Rv3571at 4013.048 kb on - strand, within Rv3571at 4013.386 kb on - strandat 4013.483 kb on - strandat 4013.560 kb on + strandat 4013.788 kb on - strand, within Rv3572at 4013.862 kb on + strand, within Rv3572at 4013.862 kb on + strand, within Rv3572at 4013.863 kb on - strand, within Rv3572at 4013.863 kb on - strand, within Rv3572at 4013.889 kb on + strand, within Rv3572at 4013.966 kb on + strand, within Rv3572at 4013.966 kb on + strand, within Rv3572at 4013.966 kb on + strand, within Rv3572at 4013.966 kb on + strand, within Rv3572at 4014.043 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Chloramphenicol 0.01 mM
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4,011,584 - Rv3570c 0.42 -0.1
4,011,710 + Rv3570c 0.53 -0.3
4,011,710 + Rv3570c 0.53 -1.0
4,011,711 - Rv3570c 0.53 -0.1
4,011,723 + Rv3570c 0.54 +0.6
4,011,723 + Rv3570c 0.54 +1.1
4,011,724 - Rv3570c 0.54 +0.1
4,012,272 + -0.7
4,012,272 + -0.9
4,012,342 - +3.1
4,012,615 - Rv3571 0.18 -1.4
4,012,960 + Rv3571 0.50 -0.8
4,012,961 - Rv3571 0.51 +0.0
4,013,048 - Rv3571 0.59 -1.1
4,013,386 - +2.8
4,013,483 - -0.0
4,013,560 + +1.8
4,013,788 - Rv3572 0.52 +0.2
4,013,862 + Rv3572 0.66 -1.8
4,013,862 + Rv3572 0.66 -0.5
4,013,863 - Rv3572 0.66 -0.8
4,013,863 - Rv3572 0.66 +0.8
4,013,889 + Rv3572 0.71 -0.0
4,013,966 + Rv3572 0.86 -0.1
4,013,966 + Rv3572 0.86 -0.4
4,013,966 + Rv3572 0.86 -0.3
4,013,966 + Rv3572 0.86 -0.7
4,014,043 + -0.1

Or see this region's nucleotide sequence