Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2521

Experiment: 7H9 with Chloramphenicol 0.01 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2519 and Rv2520c are separated by 124 nucleotidesRv2520c and Rv2521 are separated by 68 nucleotidesRv2521 and Rv2522c overlap by 29 nucleotides Rv2519: Rv2519 - PE family protein PE26, at 2,835,785 to 2,837,263 Rv2519 Rv2520c: Rv2520c - Possible conserved membrane protein, at 2,837,388 to 2,837,615 Rv2520c Rv2521: Rv2521 - Probable bacterioferritin comigratory protein Bcp, at 2,837,684 to 2,838,157 Rv2521 Rv2522c: Rv2522c - Conserved hypothetical protein, at 2,838,129 to 2,839,541 Rv2522c Position (kb) 2837 2838 2839Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 2836.776 kb on - strand, within Rv2519at 2836.776 kb on - strand, within Rv2519at 2836.862 kb on + strand, within Rv2519at 2836.863 kb on - strand, within Rv2519at 2836.968 kb on - strand, within Rv2519at 2837.074 kb on + strand, within Rv2519at 2837.088 kb on + strand, within Rv2519at 2837.089 kb on - strand, within Rv2519at 2837.089 kb on - strand, within Rv2519at 2837.179 kb on - strandat 2837.202 kb on + strandat 2837.204 kb on + strandat 2837.205 kb on - strandat 2837.206 kb on + strandat 2837.206 kb on + strandat 2837.206 kb on + strandat 2837.206 kb on + strandat 2837.207 kb on - strandat 2837.262 kb on - strandat 2837.262 kb on - strandat 2837.326 kb on - strandat 2837.673 kb on - strandat 2837.677 kb on + strandat 2837.775 kb on - strand, within Rv2521at 2837.799 kb on - strand, within Rv2521at 2837.804 kb on + strand, within Rv2521at 2837.929 kb on + strand, within Rv2521at 2838.026 kb on + strand, within Rv2521at 2838.027 kb on - strand, within Rv2521at 2838.131 kb on - strandat 2838.154 kb on - strandat 2838.155 kb on + strandat 2838.261 kb on + strandat 2838.394 kb on + strand, within Rv2522cat 2838.421 kb on + strand, within Rv2522cat 2838.543 kb on - strand, within Rv2522cat 2838.543 kb on - strand, within Rv2522cat 2838.615 kb on + strand, within Rv2522cat 2839.144 kb on + strand, within Rv2522cat 2839.144 kb on + strand, within Rv2522c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Chloramphenicol 0.01 mM
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2,836,776 - Rv2519 0.67 -0.4
2,836,776 - Rv2519 0.67 +0.7
2,836,862 + Rv2519 0.73 +1.0
2,836,863 - Rv2519 0.73 -0.6
2,836,968 - Rv2519 0.80 -1.1
2,837,074 + Rv2519 0.87 +0.9
2,837,088 + Rv2519 0.88 -0.1
2,837,089 - Rv2519 0.88 -0.7
2,837,089 - Rv2519 0.88 -3.3
2,837,179 - +0.9
2,837,202 + -0.1
2,837,204 + +0.2
2,837,205 - +0.2
2,837,206 + -0.1
2,837,206 + -0.8
2,837,206 + +1.2
2,837,206 + -0.7
2,837,207 - -0.6
2,837,262 - +1.7
2,837,262 - +0.7
2,837,326 - +0.2
2,837,673 - +0.4
2,837,677 + -0.3
2,837,775 - Rv2521 0.19 +0.5
2,837,799 - Rv2521 0.24 +0.4
2,837,804 + Rv2521 0.25 -0.1
2,837,929 + Rv2521 0.52 -0.8
2,838,026 + Rv2521 0.72 +2.7
2,838,027 - Rv2521 0.72 +1.7
2,838,131 - -0.2
2,838,154 - +0.0
2,838,155 + -0.4
2,838,261 + -0.2
2,838,394 + Rv2522c 0.19 -1.2
2,838,421 + Rv2522c 0.21 +0.1
2,838,543 - Rv2522c 0.29 +0.8
2,838,543 - Rv2522c 0.29 +0.7
2,838,615 + Rv2522c 0.34 +0.1
2,839,144 + Rv2522c 0.72 -0.2
2,839,144 + Rv2522c 0.72 -0.4

Or see this region's nucleotide sequence