Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0107c

Experiment: 7H9 with Chloramphenicol 0.01 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0106 and Rv0107c are separated by 72 nucleotidesRv0107c and Rv0108c are separated by 353 nucleotidesRv0108c and Rv0109 are separated by 277 nucleotides Rv0106: Rv0106 - Conserved hypothetical protein, at 124,374 to 125,570 Rv0106 Rv0107c: Rv0107c - Probable cation-transporter ATPase I CtpI, at 125,643 to 130,541 Rv0107c Rv0108c: Rv0108c - Hypothetical protein, at 130,895 to 131,104 Rv0108c Rv0109: Rv0109 - PE-PGRS family protein PE_PGRS1, at 131,382 to 132,872 Rv0109 Position (kb) 125 126 127 128 129 130 131Strain fitness (log2 ratio) -2 -1 0 1 2 3at 125.015 kb on + strand, within Rv0106at 125.293 kb on - strand, within Rv0106at 125.293 kb on - strand, within Rv0106at 125.293 kb on - strand, within Rv0106at 125.377 kb on + strand, within Rv0106at 125.470 kb on - strandat 125.605 kb on + strandat 125.606 kb on - strandat 125.620 kb on + strandat 125.644 kb on + strandat 125.666 kb on + strandat 127.345 kb on - strand, within Rv0107cat 127.392 kb on + strand, within Rv0107cat 127.392 kb on + strand, within Rv0107cat 128.390 kb on - strand, within Rv0107cat 128.697 kb on + strand, within Rv0107cat 128.697 kb on + strand, within Rv0107cat 128.904 kb on + strand, within Rv0107cat 128.904 kb on + strand, within Rv0107cat 129.184 kb on + strand, within Rv0107cat 129.270 kb on - strand, within Rv0107cat 129.321 kb on + strand, within Rv0107cat 129.321 kb on + strand, within Rv0107cat 129.321 kb on + strand, within Rv0107cat 129.322 kb on - strand, within Rv0107cat 129.396 kb on + strand, within Rv0107cat 129.496 kb on + strand, within Rv0107cat 129.496 kb on + strand, within Rv0107cat 129.496 kb on + strand, within Rv0107cat 129.497 kb on - strand, within Rv0107cat 129.497 kb on - strand, within Rv0107cat 129.497 kb on - strand, within Rv0107cat 129.860 kb on + strand, within Rv0107cat 129.861 kb on - strand, within Rv0107cat 129.861 kb on - strand, within Rv0107cat 130.020 kb on - strand, within Rv0107cat 130.020 kb on - strand, within Rv0107cat 130.074 kb on + strandat 130.107 kb on + strandat 130.107 kb on + strandat 130.108 kb on - strandat 130.108 kb on - strandat 130.108 kb on - strandat 130.108 kb on - strandat 130.491 kb on + strandat 130.574 kb on - strandat 130.587 kb on + strandat 130.587 kb on + strandat 130.587 kb on + strandat 130.587 kb on + strandat 130.617 kb on - strandat 130.699 kb on + strandat 130.699 kb on + strandat 130.699 kb on + strandat 130.699 kb on + strandat 130.929 kb on + strand, within Rv0108cat 131.038 kb on - strand, within Rv0108cat 131.038 kb on - strand, within Rv0108cat 131.038 kb on - strand, within Rv0108cat 131.150 kb on - strandat 131.150 kb on - strandat 131.329 kb on - strandat 131.329 kb on - strandat 131.342 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Chloramphenicol 0.01 mM
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125,015 + Rv0106 0.54 -0.4
125,293 - Rv0106 0.77 -0.1
125,293 - Rv0106 0.77 +0.6
125,293 - Rv0106 0.77 +0.9
125,377 + Rv0106 0.84 +0.2
125,470 - -0.7
125,605 + -0.4
125,606 - -0.0
125,620 + +0.3
125,644 + -0.1
125,666 + -0.4
127,345 - Rv0107c 0.35 -0.7
127,392 + Rv0107c 0.36 -0.4
127,392 + Rv0107c 0.36 -0.2
128,390 - Rv0107c 0.56 -0.5
128,697 + Rv0107c 0.62 -0.0
128,697 + Rv0107c 0.62 +0.7
128,904 + Rv0107c 0.67 -1.0
128,904 + Rv0107c 0.67 +0.8
129,184 + Rv0107c 0.72 +0.8
129,270 - Rv0107c 0.74 -0.0
129,321 + Rv0107c 0.75 -0.7
129,321 + Rv0107c 0.75 -0.0
129,321 + Rv0107c 0.75 -1.0
129,322 - Rv0107c 0.75 -0.4
129,396 + Rv0107c 0.77 -1.1
129,496 + Rv0107c 0.79 -1.5
129,496 + Rv0107c 0.79 -0.6
129,496 + Rv0107c 0.79 -0.6
129,497 - Rv0107c 0.79 -1.9
129,497 - Rv0107c 0.79 -2.6
129,497 - Rv0107c 0.79 +0.4
129,860 + Rv0107c 0.86 -1.3
129,861 - Rv0107c 0.86 -0.4
129,861 - Rv0107c 0.86 -0.2
130,020 - Rv0107c 0.89 -0.3
130,020 - Rv0107c 0.89 +0.1
130,074 + -0.9
130,107 + +0.3
130,107 + -0.4
130,108 - -0.1
130,108 - +0.2
130,108 - -0.7
130,108 - -0.3
130,491 + -0.5
130,574 - -0.8
130,587 + +3.4
130,587 + +0.6
130,587 + +1.2
130,587 + +0.8
130,617 - +0.1
130,699 + +0.0
130,699 + -0.2
130,699 + -0.1
130,699 + -0.5
130,929 + Rv0108c 0.16 -0.4
131,038 - Rv0108c 0.68 -0.5
131,038 - Rv0108c 0.68 -0.6
131,038 - Rv0108c 0.68 -1.2
131,150 - +0.3
131,150 - -0.2
131,329 - -0.1
131,329 - +0.0
131,342 - -1.3

Or see this region's nucleotide sequence