Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2092c

Experiment: 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2090 and Rv2091c are separated by 3 nucleotidesRv2091c and Rv2092c are separated by 41 nucleotidesRv2092c and Rv2093c are separated by 48 nucleotidesRv2093c and Rv2094c are separated by 16 nucleotides Rv2090: Rv2090 - Probable 5'-3' exonuclease, at 2,347,373 to 2,348,554 Rv2090 Rv2091c: Rv2091c - Probable membrane protein, at 2,348,558 to 2,349,292 Rv2091c Rv2092c: Rv2092c - ATP-dependent DNA helicase HelY, at 2,349,334 to 2,352,054 Rv2092c Rv2093c: Rv2093c - Sec-independent protein translocase transmembrane protein TatC, at 2,352,103 to 2,353,029 Rv2093c Rv2094c: Rv2094c - Sec-independent protein translocase membrane-bound protein TatA, at 2,353,046 to 2,353,297 Rv2094c Position (kb) 2349 2350 2351 2352 2353Strain fitness (log2 ratio) -2 -1 0 1 2 3 4at 2348.340 kb on + strand, within Rv2090at 2348.340 kb on + strand, within Rv2090at 2348.340 kb on + strand, within Rv2090at 2348.341 kb on - strand, within Rv2090at 2348.345 kb on - strand, within Rv2090at 2348.345 kb on - strand, within Rv2090at 2348.345 kb on - strand, within Rv2090at 2348.345 kb on - strand, within Rv2090at 2348.370 kb on - strand, within Rv2090at 2348.560 kb on - strandat 2348.560 kb on - strandat 2348.580 kb on + strandat 2348.580 kb on + strandat 2348.581 kb on - strandat 2348.773 kb on + strand, within Rv2091cat 2348.829 kb on - strand, within Rv2091cat 2348.919 kb on + strand, within Rv2091cat 2348.976 kb on + strand, within Rv2091cat 2348.976 kb on + strand, within Rv2091cat 2348.994 kb on + strand, within Rv2091cat 2349.012 kb on + strand, within Rv2091cat 2349.021 kb on + strand, within Rv2091cat 2349.021 kb on + strand, within Rv2091cat 2349.022 kb on - strand, within Rv2091cat 2349.135 kb on + strand, within Rv2091cat 2349.320 kb on - strandat 2349.378 kb on + strandat 2349.734 kb on + strand, within Rv2092cat 2349.734 kb on + strand, within Rv2092cat 2349.735 kb on - strand, within Rv2092cat 2349.795 kb on + strand, within Rv2092cat 2349.795 kb on + strand, within Rv2092cat 2349.799 kb on + strand, within Rv2092cat 2349.799 kb on + strand, within Rv2092cat 2349.976 kb on + strand, within Rv2092cat 2350.003 kb on + strand, within Rv2092cat 2350.003 kb on + strand, within Rv2092cat 2350.004 kb on - strand, within Rv2092cat 2350.004 kb on - strand, within Rv2092cat 2350.007 kb on + strand, within Rv2092cat 2350.008 kb on - strand, within Rv2092cat 2350.050 kb on + strand, within Rv2092cat 2350.050 kb on + strand, within Rv2092cat 2350.050 kb on + strand, within Rv2092cat 2350.051 kb on - strand, within Rv2092cat 2350.051 kb on - strand, within Rv2092cat 2350.143 kb on + strand, within Rv2092cat 2350.143 kb on + strand, within Rv2092cat 2350.143 kb on + strand, within Rv2092cat 2350.144 kb on - strand, within Rv2092cat 2350.300 kb on + strand, within Rv2092cat 2350.502 kb on + strand, within Rv2092cat 2350.555 kb on + strand, within Rv2092cat 2350.555 kb on + strand, within Rv2092cat 2350.841 kb on + strand, within Rv2092cat 2350.841 kb on + strand, within Rv2092cat 2350.842 kb on - strand, within Rv2092cat 2350.842 kb on - strand, within Rv2092cat 2351.047 kb on + strand, within Rv2092cat 2351.067 kb on - strand, within Rv2092cat 2351.067 kb on - strand, within Rv2092cat 2351.070 kb on - strand, within Rv2092cat 2351.291 kb on + strand, within Rv2092cat 2351.706 kb on - strand, within Rv2092cat 2351.861 kb on + strandat 2351.862 kb on - strandat 2351.872 kb on - strandat 2352.013 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM
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2,348,340 + Rv2090 0.82 +0.6
2,348,340 + Rv2090 0.82 -0.4
2,348,340 + Rv2090 0.82 -1.2
2,348,341 - Rv2090 0.82 +0.2
2,348,345 - Rv2090 0.82 -0.2
2,348,345 - Rv2090 0.82 -2.0
2,348,345 - Rv2090 0.82 +0.1
2,348,345 - Rv2090 0.82 +1.0
2,348,370 - Rv2090 0.84 +0.3
2,348,560 - +2.6
2,348,560 - +1.3
2,348,580 + -0.3
2,348,580 + +0.5
2,348,581 - +0.4
2,348,773 + Rv2091c 0.29 -0.0
2,348,829 - Rv2091c 0.37 -2.1
2,348,919 + Rv2091c 0.49 -1.1
2,348,976 + Rv2091c 0.57 -0.6
2,348,976 + Rv2091c 0.57 +3.8
2,348,994 + Rv2091c 0.59 -0.9
2,349,012 + Rv2091c 0.62 -1.1
2,349,021 + Rv2091c 0.63 +1.1
2,349,021 + Rv2091c 0.63 -2.1
2,349,022 - Rv2091c 0.63 -0.5
2,349,135 + Rv2091c 0.79 -0.7
2,349,320 - -1.7
2,349,378 + +0.4
2,349,734 + Rv2092c 0.15 +0.5
2,349,734 + Rv2092c 0.15 +0.4
2,349,735 - Rv2092c 0.15 +0.6
2,349,795 + Rv2092c 0.17 -1.3
2,349,795 + Rv2092c 0.17 -0.2
2,349,799 + Rv2092c 0.17 +0.2
2,349,799 + Rv2092c 0.17 +0.3
2,349,976 + Rv2092c 0.24 +0.1
2,350,003 + Rv2092c 0.25 -1.3
2,350,003 + Rv2092c 0.25 +0.3
2,350,004 - Rv2092c 0.25 +0.8
2,350,004 - Rv2092c 0.25 -0.4
2,350,007 + Rv2092c 0.25 -0.5
2,350,008 - Rv2092c 0.25 +0.7
2,350,050 + Rv2092c 0.26 -0.1
2,350,050 + Rv2092c 0.26 +0.3
2,350,050 + Rv2092c 0.26 +0.8
2,350,051 - Rv2092c 0.26 +0.9
2,350,051 - Rv2092c 0.26 +0.9
2,350,143 + Rv2092c 0.30 +0.0
2,350,143 + Rv2092c 0.30 -0.3
2,350,143 + Rv2092c 0.30 +0.4
2,350,144 - Rv2092c 0.30 +0.9
2,350,300 + Rv2092c 0.36 +0.1
2,350,502 + Rv2092c 0.43 +0.3
2,350,555 + Rv2092c 0.45 -0.2
2,350,555 + Rv2092c 0.45 +1.0
2,350,841 + Rv2092c 0.55 -0.1
2,350,841 + Rv2092c 0.55 +0.5
2,350,842 - Rv2092c 0.55 +0.2
2,350,842 - Rv2092c 0.55 -0.6
2,351,047 + Rv2092c 0.63 +1.3
2,351,067 - Rv2092c 0.64 +0.2
2,351,067 - Rv2092c 0.64 +1.3
2,351,070 - Rv2092c 0.64 -0.8
2,351,291 + Rv2092c 0.72 +0.9
2,351,706 - Rv2092c 0.87 -1.3
2,351,861 + +1.9
2,351,862 - +0.1
2,351,872 - +0.8
2,352,013 + -0.1

Or see this region's nucleotide sequence