Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0552

Experiment: 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0551c and Rv0552 are separated by 77 nucleotidesRv0552 and Rv0553 overlap by 4 nucleotidesRv0553 and Rv0554 overlap by 4 nucleotides Rv0551c: Rv0551c - Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase), at 641,096 to 642,811 Rv0551c Rv0552: Rv0552 - Conserved protein, at 642,889 to 644,493 Rv0552 Rv0553: Rv0553 - Probable muconate cycloisomerase MenC (cis,cis-muconate lactonizing enzyme) (MLE), at 644,490 to 645,470 Rv0553 Rv0554: Rv0554 - Possible peroxidase BpoC (non-haem peroxidase), at 645,467 to 646,255 Rv0554 Position (kb) 642 643 644 645Strain fitness (log2 ratio) -1 0 1 2at 642.045 kb on - strand, within Rv0551cat 642.239 kb on + strand, within Rv0551cat 642.239 kb on + strand, within Rv0551cat 642.397 kb on - strand, within Rv0551cat 642.556 kb on - strand, within Rv0551cat 642.565 kb on + strand, within Rv0551cat 642.779 kb on + strandat 642.779 kb on + strandat 642.823 kb on - strandat 642.823 kb on - strandat 643.342 kb on + strand, within Rv0552at 643.411 kb on + strand, within Rv0552at 643.411 kb on + strand, within Rv0552at 643.487 kb on + strand, within Rv0552at 643.837 kb on + strand, within Rv0552at 643.945 kb on + strand, within Rv0552at 643.945 kb on + strand, within Rv0552at 644.083 kb on + strand, within Rv0552at 644.083 kb on + strand, within Rv0552at 644.175 kb on + strand, within Rv0552at 644.175 kb on + strand, within Rv0552at 644.389 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM
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642,045 - Rv0551c 0.55 +0.4
642,239 + Rv0551c 0.67 +0.1
642,239 + Rv0551c 0.67 +1.8
642,397 - Rv0551c 0.76 -0.7
642,556 - Rv0551c 0.85 -0.7
642,565 + Rv0551c 0.86 -0.3
642,779 + +0.1
642,779 + +1.9
642,823 - -0.0
642,823 - -0.7
643,342 + Rv0552 0.28 +1.9
643,411 + Rv0552 0.33 -0.8
643,411 + Rv0552 0.33 -1.2
643,487 + Rv0552 0.37 -0.6
643,837 + Rv0552 0.59 -1.3
643,945 + Rv0552 0.66 -0.8
643,945 + Rv0552 0.66 -0.3
644,083 + Rv0552 0.74 -0.4
644,083 + Rv0552 0.74 +0.2
644,175 + Rv0552 0.80 -0.4
644,175 + Rv0552 0.80 -1.0
644,389 - -0.2

Or see this region's nucleotide sequence