Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3439c

Experiment: 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3437 and Rv3438 are separated by 9 nucleotidesRv3438 and Rv3439c are separated by 19 nucleotidesRv3439c and Rv3440c are separated by 2 nucleotidesRv3440c and Rv3441c are separated by 47 nucleotides Rv3437: Rv3437 - Possible conserved transmembrane protein, at 3,856,911 to 3,857,387 Rv3437 Rv3438: Rv3438 - Conserved protein, at 3,857,397 to 3,858,239 Rv3438 Rv3439c: Rv3439c - Conserved hypothetical alanine and proline rich protein, at 3,858,259 to 3,859,662 Rv3439c Rv3440c: Rv3440c - Hypothetical protein, at 3,859,665 to 3,859,976 Rv3440c Rv3441c: Rv3441c - Probable phospho-sugar mutase / MrsA protein homolog, at 3,860,024 to 3,861,370 Rv3441c Position (kb) 3858 3859 3860Strain fitness (log2 ratio) -2 -1 0 1 2at 3857.578 kb on + strand, within Rv3438at 3857.578 kb on + strand, within Rv3438at 3857.882 kb on - strand, within Rv3438at 3858.132 kb on + strand, within Rv3438at 3858.133 kb on - strand, within Rv3438at 3858.133 kb on - strand, within Rv3438at 3859.037 kb on + strand, within Rv3439cat 3859.037 kb on + strand, within Rv3439cat 3859.038 kb on - strand, within Rv3439cat 3859.038 kb on - strand, within Rv3439cat 3859.109 kb on + strand, within Rv3439cat 3859.109 kb on + strand, within Rv3439cat 3859.117 kb on + strand, within Rv3439cat 3859.117 kb on + strand, within Rv3439cat 3859.118 kb on - strand, within Rv3439cat 3859.417 kb on - strand, within Rv3439cat 3859.417 kb on - strand, within Rv3439cat 3859.592 kb on + strandat 3859.789 kb on - strand, within Rv3440cat 3859.927 kb on + strand, within Rv3440cat 3859.928 kb on - strand, within Rv3440cat 3859.938 kb on + strand, within Rv3440cat 3859.938 kb on + strand, within Rv3440cat 3859.938 kb on + strand, within Rv3440cat 3859.939 kb on - strand, within Rv3440cat 3859.939 kb on - strand, within Rv3440cat 3859.939 kb on - strand, within Rv3440cat 3859.939 kb on - strand, within Rv3440cat 3859.939 kb on - strand, within Rv3440cat 3859.939 kb on - strand, within Rv3440cat 3859.939 kb on - strand, within Rv3440cat 3859.939 kb on - strand, within Rv3440cat 3859.945 kb on - strandat 3859.945 kb on - strandat 3859.945 kb on - strandat 3859.959 kb on + strandat 3859.959 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM
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3,857,578 + Rv3438 0.21 -1.9
3,857,578 + Rv3438 0.21 -2.3
3,857,882 - Rv3438 0.58 -1.0
3,858,132 + Rv3438 0.87 -0.0
3,858,133 - Rv3438 0.87 -0.7
3,858,133 - Rv3438 0.87 -0.7
3,859,037 + Rv3439c 0.55 -0.5
3,859,037 + Rv3439c 0.55 -0.4
3,859,038 - Rv3439c 0.55 +0.6
3,859,038 - Rv3439c 0.55 -1.8
3,859,109 + Rv3439c 0.61 -0.2
3,859,109 + Rv3439c 0.61 -0.1
3,859,117 + Rv3439c 0.61 -0.3
3,859,117 + Rv3439c 0.61 -2.0
3,859,118 - Rv3439c 0.61 +0.5
3,859,417 - Rv3439c 0.82 +1.4
3,859,417 - Rv3439c 0.82 -1.1
3,859,592 + +0.1
3,859,789 - Rv3440c 0.40 -2.1
3,859,927 + Rv3440c 0.84 +0.2
3,859,928 - Rv3440c 0.84 -0.3
3,859,938 + Rv3440c 0.88 -1.4
3,859,938 + Rv3440c 0.88 +0.1
3,859,938 + Rv3440c 0.88 +0.4
3,859,939 - Rv3440c 0.88 -0.2
3,859,939 - Rv3440c 0.88 -0.2
3,859,939 - Rv3440c 0.88 +0.2
3,859,939 - Rv3440c 0.88 +0.7
3,859,939 - Rv3440c 0.88 -1.3
3,859,939 - Rv3440c 0.88 -0.1
3,859,939 - Rv3440c 0.88 -1.3
3,859,939 - Rv3440c 0.88 -0.3
3,859,945 - -0.2
3,859,945 - -0.5
3,859,945 - +1.9
3,859,959 + +0.5
3,859,959 + -0.0

Or see this region's nucleotide sequence