Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1316c

Experiment: 7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntGFF1370 and GFF1371 are separated by 103 nucleotidesGFF1371 and Rv1316c are separated by 120 nucleotidesRv1316c and Rv1317c overlap by 4 nucleotides GFF1370 - Ribosomal RNA 23S, at 1,473,658 to 1,476,795 GFF1370 GFF1371 - Ribosomal RNA 5S, at 1,476,899 to 1,477,013 GFF1371 Rv1316c: Rv1316c - Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltransferase), at 1,477,134 to 1,477,631 Rv1316c Rv1317c: Rv1317c - Probable bifunctional regulatory protein and DNA repair enzyme AlkA (regulatory protein of adaptative response) (methylphosphotriester-DNA--protein-cysteine S-methyltransferase), at 1,477,628 to 1,479,118 Rv1317c Position (kb) 1477 1478Strain fitness (log2 ratio) -1 0 1at 1477.054 kb on + strandat 1477.055 kb on - strandat 1477.349 kb on - strand, within Rv1316cat 1477.393 kb on - strand, within Rv1316cat 1477.462 kb on + strand, within Rv1316cat 1477.534 kb on + strand, within Rv1316cat 1477.534 kb on + strand, within Rv1316cat 1477.534 kb on + strand, within Rv1316cat 1477.535 kb on - strand, within Rv1316cat 1477.535 kb on - strand, within Rv1316cat 1477.535 kb on - strand, within Rv1316cat 1477.535 kb on - strand, within Rv1316cat 1477.590 kb on + strandat 1477.701 kb on + strandat 1477.701 kb on + strandat 1477.701 kb on + strandat 1477.702 kb on - strandat 1477.881 kb on - strand, within Rv1317cat 1477.965 kb on - strand, within Rv1317cat 1477.965 kb on - strand, within Rv1317cat 1477.965 kb on - strand, within Rv1317cat 1478.130 kb on - strand, within Rv1317cat 1478.130 kb on - strand, within Rv1317cat 1478.416 kb on - strand, within Rv1317c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM
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1,477,054 + -0.8
1,477,055 - -0.3
1,477,349 - Rv1316c 0.43 -0.6
1,477,393 - Rv1316c 0.52 -1.0
1,477,462 + Rv1316c 0.66 -0.0
1,477,534 + Rv1316c 0.80 -0.1
1,477,534 + Rv1316c 0.80 -0.5
1,477,534 + Rv1316c 0.80 -1.2
1,477,535 - Rv1316c 0.81 -1.1
1,477,535 - Rv1316c 0.81 +0.0
1,477,535 - Rv1316c 0.81 -0.9
1,477,535 - Rv1316c 0.81 -1.7
1,477,590 + +0.2
1,477,701 + +0.9
1,477,701 + +0.9
1,477,701 + +0.6
1,477,702 - -1.3
1,477,881 - Rv1317c 0.17 -1.4
1,477,965 - Rv1317c 0.23 -1.5
1,477,965 - Rv1317c 0.23 +0.1
1,477,965 - Rv1317c 0.23 -0.3
1,478,130 - Rv1317c 0.34 -0.5
1,478,130 - Rv1317c 0.34 -0.4
1,478,416 - Rv1317c 0.53 +0.3

Or see this region's nucleotide sequence