Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1714

Experiment: 7H9 with Lomefloxacin 0.0035 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1713 and Rv1714 are separated by 173 nucleotidesRv1714 and Rv1715 overlap by 7 nucleotidesRv1715 and Rv1716 are separated by 2 nucleotides Rv1713: Rv1713 - Probable GTP-binding protein EngA, at 1,940,288 to 1,941,679 Rv1713 Rv1714: Rv1714 - Probable oxidoreductase, at 1,941,853 to 1,942,665 Rv1714 Rv1715: Rv1715 - Probable 3-hydroxybutyryl-CoA dehydrogenase FadB3 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD), at 1,942,659 to 1,943,573 Rv1715 Rv1716: Rv1716 - Conserved hypothetical protein, at 1,943,576 to 1,944,406 Rv1716 Position (kb) 1941 1942 1943Strain fitness (log2 ratio) -1 0 1at 1942.191 kb on + strand, within Rv1714at 1942.192 kb on - strand, within Rv1714at 1942.636 kb on + strandat 1942.859 kb on - strand, within Rv1715at 1943.340 kb on + strand, within Rv1715at 1943.340 kb on + strand, within Rv1715at 1943.625 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Lomefloxacin 0.0035 mM
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1,942,191 + Rv1714 0.42 -0.7
1,942,192 - Rv1714 0.42 -0.4
1,942,636 + +0.6
1,942,859 - Rv1715 0.22 -0.1
1,943,340 + Rv1715 0.74 -1.1
1,943,340 + Rv1715 0.74 -0.5
1,943,625 - -0.1

Or see this region's nucleotide sequence