Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2967c

Experiment: 7H9 with Benzethonium chloride 0.068 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2965c and Rv2966c are separated by 85 nucleotidesRv2966c and Rv2967c are separated by 195 nucleotidesRv2967c and Rv2968c are separated by 24 nucleotidesRv2968c and Rv2969c are separated by 5 nucleotides Rv2965c: Rv2965c - Probable phosphopantetheine adenylyltransferase KdtB (pantetheine-phosphate adenylyltransferase) (PPAT) (dephospho-CoA pyrophosphorylase), at 3,318,330 to 3,318,815 Rv2965c Rv2966c: Rv2966c - Possible methyltransferase (methylase), at 3,318,901 to 3,319,467 Rv2966c Rv2967c: Rv2967c - Probable pyruvate carboxylase Pca (pyruvic carboxylase), at 3,319,663 to 3,323,046 Rv2967c Rv2968c: Rv2968c - Probable conserved integral membrane protein, at 3,323,071 to 3,323,703 Rv2968c Rv2969c: Rv2969c - Possible conserved membrane or secreted protein, at 3,323,709 to 3,324,476 Rv2969c Position (kb) 3319 3320 3321 3322 3323 3324Strain fitness (log2 ratio) -3 -2 -1 0 1at 3318.902 kb on + strandat 3318.902 kb on + strandat 3319.104 kb on - strand, within Rv2966cat 3319.934 kb on - strandat 3320.078 kb on + strand, within Rv2967cat 3320.338 kb on + strand, within Rv2967cat 3320.816 kb on + strand, within Rv2967cat 3320.816 kb on + strand, within Rv2967cat 3320.817 kb on - strand, within Rv2967cat 3320.817 kb on - strand, within Rv2967cat 3321.153 kb on + strand, within Rv2967cat 3321.213 kb on - strand, within Rv2967cat 3321.238 kb on + strand, within Rv2967cat 3321.256 kb on - strand, within Rv2967cat 3321.387 kb on - strand, within Rv2967cat 3322.196 kb on + strand, within Rv2967cat 3322.197 kb on - strand, within Rv2967cat 3322.374 kb on - strand, within Rv2967cat 3322.374 kb on - strand, within Rv2967cat 3322.808 kb on + strandat 3322.812 kb on + strandat 3322.865 kb on + strandat 3322.865 kb on + strandat 3322.865 kb on + strandat 3322.866 kb on - strandat 3322.866 kb on - strandat 3322.946 kb on + strandat 3322.953 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Benzethonium chloride 0.068 mM
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3,318,902 + +0.2
3,318,902 + -0.1
3,319,104 - Rv2966c 0.36 -0.7
3,319,934 - -1.4
3,320,078 + Rv2967c 0.12 -0.7
3,320,338 + Rv2967c 0.20 -1.5
3,320,816 + Rv2967c 0.34 -0.1
3,320,816 + Rv2967c 0.34 +0.3
3,320,817 - Rv2967c 0.34 -1.8
3,320,817 - Rv2967c 0.34 -1.9
3,321,153 + Rv2967c 0.44 -1.1
3,321,213 - Rv2967c 0.46 -0.7
3,321,238 + Rv2967c 0.47 -0.6
3,321,256 - Rv2967c 0.47 -0.8
3,321,387 - Rv2967c 0.51 +0.1
3,322,196 + Rv2967c 0.75 +1.5
3,322,197 - Rv2967c 0.75 +0.1
3,322,374 - Rv2967c 0.80 -0.7
3,322,374 - Rv2967c 0.80 -1.1
3,322,808 + -3.6
3,322,812 + -1.2
3,322,865 + -0.8
3,322,865 + -0.9
3,322,865 + -0.7
3,322,866 - -0.2
3,322,866 - -0.1
3,322,946 + +0.5
3,322,953 - -1.2

Or see this region's nucleotide sequence